Now showing items 21-40 of 91

    • Competing risks methods 

      Porta Bleda, Núria; Gómez Melis, Guadalupe; Calle Rosingana, M. Luz; Malats i Riera, Núria (2007-12-10)
      Research report
      Open Access
      Competing risks data usually arises in studies in which the failure of an individual may be classified into one of k (k > 1) mutually exclusive causes of failure. When competing risks are present, classical survival analysis ...
    • Covid-19: la malinterpretación de los datos de la pandemia daña la confianza del público 

      Saez Zafra, Marc; Figueiras Guzmán, Adolfo; Alustiza, Ainhoa; Fernández Martínez, Daniel; Cobo Valeri, Erik; Gómez Melis, Guadalupe; González Alastrué, José Antonio; Fonseca Casas, Pau; Cortés García, Claudio Ulises (2020-11-04)
      Article
      Open Access
    • Decision tool and Sample Size Calculator for composite endpoints 

      Bofill Roig, Marta; Cortés Martínez, Jordi; Gómez Melis, Guadalupe (2020-01-10)
      Article
      Open Access
      This article considers the combination of two binary or two time-to-event endpoints to form the primary composite endpoint for leading a trial. • It discusses the relative efficiency of choosing a composite endpoint over ...
    • Definition of the viral targets of protective HIV-1-specific T cell responses 

      Pérez-Alvarez, Susana; Mothe, Beatriz; Llano, Anuska; Ibarrondo, Javier; Daniels, Marcus; Miranda, Cristina; Zamarreño, Jennifer; Bach, Vanessa; Zuniga, Rosario; Brander, C.; Sanchez, Jorge; Brumme, Chanson J.; Sánchez-Merino, Victor; Yang, Otto O.; Hildebrand, William H.; Szinger, James J.; Farfan, Marilu; Rolland, Morgane; Martínez-Picado, Javier; Puertas, Maria C.; Berger, Chistoph T.; Brumme, Zabrina L.; Korber, Bette T.; Gatell, Jose M.; Clotet, Bonaventura; Goulder, Philip J.; Walker, Bruce D.; Mullins, James I.; Gómez Melis, Guadalupe; Heckerman, David; Allen, Todd M. (2011-12-07)
      Article
      Open Access
      Background: The efficacy of the CTL component of a future HIV-1 vaccine will depend on the induction of responses with the most potent antiviral activity and broad HLA class I restriction. However, current HIV vaccine ...
    • Descripción de la supervivencia con indicadores numéricos y gráficos: conceptos básicos y errores que evitar 

      Gómez Melis, Guadalupe; Cortés Martínez, Jordi; Cobo Valeri, Erik (2022-02-15)
      Article
      Open Access
    • Design of phase III trials with long-term survival outcomes based on short-term binary results 

      Bofill Roig, Marta; Shen, Yunyi; Gómez Melis, Guadalupe (2021-05-03)
      Article
      Open Access
      Pathologic complete response (pCR) is a common primary endpoint for a phase II trial or even accelerated approval of neoadjuvant cancer therapy. If granted, a two-arm confirmatory trial is often required to demonstrate the ...
    • Design of trials with composite endpoints with the R package compAREdesign 

      Cortés Martínez, Jordi; Bofill Roig, Marta; Gómez Melis, Guadalupe (2022-11-04)
      Article
      Open Access
      Composite endpoints are widely used as primary endpoints in clinical trials. Designing trials with time-to-event endpoints can be particularly challenging because the proportional hazard assumption usually does not hold ...
    • Effect of changing the copular when choosing the primary endpoint in a Randomized Clinical Trial 

      Plana Ripoll, Oleguer; Gómez Melis, Guadalupe (2013)
      Conference report
      Open Access
    • Estadística Matemàtica 2 

      Gómez Melis, Guadalupe (Universitat Politècnica de Catalunya, 1994)
      Lecture notes
      Open Access
    • Estadística Matemàtica 2 

      Gómez Melis, Guadalupe (Universitat Politècnica de Catalunya, 1994)
      Lecture notes
      Open Access
    • Estadística matemàtica 2 

      Gómez Melis, Guadalupe (Universitat Politècnica de Catalunya, 1994)
      Lecture notes
      Open Access
    • Estadística Matemàtica 2 

      Gómez Melis, Guadalupe (Universitat Politècnica de Catalunya, 1994)
      Lecture notes
      Open Access
    • Estadística matemática I 

      Gómez Melis, Guadalupe (Universitat Politècnica de Catalunya, 2002-07)
      Lecture notes
      Open Access
    • Estadística matemática I 

      Gómez Melis, Guadalupe; Nonell i Torrent, Ramon; Delicado Useros, Pedro Francisco (Universitat Politècnica de Catalunya, 2001)
      Problem statement, exercise
      Open Access
    • Estudio de los factores asociados a la pérdida de densidad mineral ósea en pacientes infectados con VIH 

      Figueras-Balsells, M.; Pérez Álvarez, Nuria; Negredo, Eugènia; Estany, C.; Bonjoch, A.; Gómez Melis, Guadalupe (2009)
      Conference report
      Open Access
    • Extension of the asymptotic relative efficiency method to select the primary endpoint in a randomized clinical trial 

      Plana-Ripoll, Oleguer; Gómez Melis, Guadalupe (2014-10-13)
      Research report
      Open Access
      We extend the ARE method proposed in Gómez and Lagakos (2013) devised to decide which primary endpoint to choose when comparing two treatments in a randomized clinical trial. The ARE method is based on the Asymptotic ...
    • Extensions and applications of CompARE : web platform to select the primary endpoint in a randomized clinical trial 

      Gómez Mateu, Moisés; Gómez Melis, Guadalupe (Fundación Mapfre, 2015)
      Conference report
      Open Access
      We present CompARE, a web platform that computes how more efficient is to use a composite endpoint instead of one of its components. CompARE is based on the Asymptotic Relative Efficiency (ARE) method develop by Gómez and ...
    • FARMS: a new algorithm for variable selection 

      Pérez Álvarez, Susana; Gómez Melis, Guadalupe; Brander, Christian (2015-01-01)
      Article
      Open Access
      Large datasets including an extensive number of covariates are generated these days in many different situations, for instance, in detailed genetic studies of outbreed human populations or in complex analyses of immune ...
    • Flexible geoadditive survival analysis of non-Hodgkin lymphoma in Peru 

      Flores, Claudio; Rodríguez-Girondo, Mar; Cadarso Suárez, Carmen; Kneib, Thomas; Gómez Melis, Guadalupe; Casanova, Lluis (2012-06)
      Article
      Open Access
      Knowledge of prognostic factors is an important task for the clinical management of Non Hodgkin Lymphoma (NHL). In this work, we study the variables affecting survival of NHL in Peru by means of geoadditive Cox-type ...
    • Flexible geoadditive survival analysis of non-Hodgkin lymphoma in Peru 

      Flores, Carlos; Rodríguez-Girondo, Mar; Cadarso-Suárez, Carmen; Kneib, Thomas; Gómez Melis, Guadalupe; Casanova, Luís (Institut d'Estadística de Catalunya, 2012)
      Article
      Open Access
      Knowledge of prognostic factors is an important task for the clinical management of Non Hodgkin Lymphoma (NHL). In this work, we study the variables affecting survival of NHL in Peru by means of geoadditive Cox-type ...