Now showing items 1-20 of 43

    • Antibacterial coatings on medical devices 

      Ivanova, Kristina Dimitrova; Bassegoda Puigdomenech, Arnau; Tzanov, Tzanko (Elsevier, 2017-11-02)
      Part of book or chapter of book
      Restricted access - publisher's policy
    • Antibacterial polyurethane foams with incorporated lignin-capped silver nanoparticles for chronic wound treatment 

      Morena Gatius, Ángela Gala; Ivanova, Kristina Dimitrova; Pérez Rafael, Silvia; Sánchez Soto, Miguel; Tzanov, Tzanko; Stefanov, Ivaylo (2020-02-26)
      Article
      Open Access
      Lignin-capped silver nanoparticles were incorporated in situ into polyurethane foams during their polymerization to obtain multifunctional materials suitable for chronic wound dressing. Lignin with increased phenolic ...
    • Antibacterial, antibiofilm, and antiviral farnesol-containing nanoparticles prevent Staphylococcus aureus from drug resistance development 

      Ivanova, Aleksandra Asenova; Ivanova, Kristina Dimitrova; Fiandra, Luisa; Mantecca, Paride; Catelani, Tiziano; Natan, Michal; Banin, Ehud; Jacobi, Gila; Tzanov, Tzanko (2022-07-07)
      Article
      Open Access
      Multidrug antimicrobial resistance is a constantly growing health care issue associated with increased mortality and morbidity, and huge financial burden. Bacteria frequently form biofilm communities responsible for numerous ...
    • Antibiofilm poly(carboxybetaine methacrylate) hydrogels for chronic wounds dressings 

      Ruseva, Konstans; Ivanova, Kristina Dimitrova; Todorova, Katerina; Vladov, Ivelin; Nanev, Vesselin; Tzanov, Tzanko; Hinojosa-Caballero, Dolores; Argirova, Maya; Vassileva, Elena (Elsevier, 2020-04-12)
      Article
      Open Access
      The current study demonstrates the benefits of poly(carboxybetaine methacrylate) hydrogels in chronic wound healing. These hydrogels demonstrate high absorbing capacity upon swelling in salt solutions thus revealing great ...
    • Antibody-enabled antimicrobial nanocapsules for selective elimination of Staphylococcus aureus 

      Ivanova, Kristina Dimitrova; Ivanova, Aleksandra Asenova; Ramon Portés, Eva; Hoyo Pérez, Javier; Sanchez-Gomez, Susana; Tzanov, Tzanko (2020-07-16)
      Article
      Open Access
      Targeted bactericide nanosystems hold significant promise to improve the efficacy of existing antimicrobials for treatment of severe bacterial infections, minimizing the side effects and lowering the risk of antibiotic ...
    • Antimicrobial lightweight materials and components 

      Morena Gatius, Ángela Gala; Ferreres Cabanes, Guillem; Ivanova, Kristina Dimitrova; Pérez Rafael, Silvia; Tzanov, Tzanko (Elsevier, 2020-12-02)
      Part of book or chapter of book
      Restricted access - publisher's policy
      Lightweight materials and components have gained remarkable scientific and technological importance in the recent times as the main drivers of innovation. They are finding widespread use across all industry sectors to ...
    • Bacteria-responsive multilayer coatings comprising polycationic nanospheres for bacteria biofilm prevention on urinary catheters 

      Francesko, Antonio; Macedo Fernandes, Margarida Maria; Ivanova, Kristina Dimitrova; Tzanov, Tzanko (2016-01-21)
      Article
      Open Access
      This work reports on the development of infection-preventive coatings on silicone urinary catheters that contain in their structure and release on demand antibacterial polycationic nanospheres. Polycationic aminocellulose ...
    • Bio-based nano-enabled cosmetic formulations for the treatment of cutibacterium acnes-associated skin infections 

      Ivanova, Kristina Dimitrova; Ramon Portés, Eva; Ivanova, Aleksandra Asenova; Sanchez-Gomez, Susana; Tzanov, Tzanko (2023-02-09)
      Article
      Open Access
      Acne is a common chronic skin condition with serious physical and psychosocial consequences. In some cases, the appearance of pimples, whiteheads, or blackheads on the face, neck, and back may lead to scarring, disfiguring, ...
    • Bottom-up layer-by-layer assembling of antibacterial freestanding nanobiocomposite films 

      Francesko, Antonio; Ivanova, Kristina Dimitrova; Hoyo Pérez, Javier; Pérez-Rafael, Silvia; Petkova, Petya; Fernandes Macedo, Margarida Maria; Heinze, Thomas; Mendoza Gómez, Ernesto; Tzanov, Tzanko (2018-07-27)
      Article
      Open Access
      In this study, freestanding nanobiocomposite films were obtained by the sequential deposition of biopolymer-capped silver nanoparticles (AgNPs) and hyaluronic acid (HA). At first, dispersions ofAgNPs decorated with chitosan ...
    • Durable bio-based nanocomposite coating on urinary catheters prevents early-stage CAUTI-associated pathogenicity 

      Puertas Segura, Antonio Jesús; Ivanova, Kristina Dimitrova; Pérez, Leonardo Martín; Bzazou El Ouazzani, Zine El abidine; Ivanova, Aleksandra Asenova; Gökalsin, Baris; Ciardelli, Gianluca; Tzanov, Tzanko (John Wiley & sons, 2025-02-10)
      Article
      Open Access
      Recurrent catheter-associated urinary tract infections (CAUTIs) in catheterized patients, increase their morbidity and hospital stay at substantial costs for healthcare systems. Hence, novel and efficient strategies for ...
    • Electrical evaluation of bacterial virulence factors using nanopores 

      Escosura Muñiz, Alfredo de la; Ivanova, Kristina Dimitrova; Tzanov, Tzanko (2019-03-19)
      Article
      Open Access
      In this work, we propose a novel methodology for electrical monitoring using nanoporous alumina membranes of virulence factors secreted by bacterial pathogens. Bacterial hyaluronidase (HYAL), which is produced by a number ...
    • Enzymatically built nanoenabled antimicrobial coating on urinary catheters 

      Puertas Segura, Antonio Jesús; Morena Gatius, Ángela Gala; Pérez Rafael, Silvia; Ivanova, Kristina Dimitrova; Ivanov, Ivan; Todorova, Katerina; Dimitrov, Petar; Ciardeli, Gianluca; Tzanov, Tzanko (2024-07-23)
      Article
      Open Access
      Catheter-associated urinary tract infections represent a major share of nosocomial infections, and are associated with longer periods of hospitalization and a huge financial burden. Currently, there are only a handful of ...
    • Enzyme multilayer coatings inhibit Pseudomonas aeruginosa biofilm formation on urinary catheters 

      Ivanova, Kristina Dimitrova; Macedo Fernandes, Margarida Maria; Mendoza Gómez, Ernesto; Tzanov, Tzanko (2015-01-15)
      Article
      Open Access
      Bacteria use a signaling mechanism called quorum sensing (QS) to form complex communities of surface-attached cells known as biofilms. This protective mode of growth allows them to resist antibiotic treatment and originates ...
    • Escherichia coli and pseudomonas aeruginosa eradication by nano-penicillin G 

      Macedo Fernandes, Margarida Maria; Ivanova, Kristina Dimitrova; Francesko, Antonio; Rivera, Diana; Torrent Burgués, Juan; Mendoza Gómez, Ernesto; Tzanov, Tzanko (2016-06-09)
      Article
      Open Access
      The transformation of penicillin G into nano/micro-sized spheres (nanopenicillin) using sonochemical technology was explored as a novel tool for the eradication of Gram-negative bacteria and their biofilms. Known by its ...
    • Immobilization of antimicrobial core-shell nanospheres onto silicone for prevention of Escherichia coli biofilm formation 

      Macedo Fernandes, Margarida Maria; Ivanova, Kristina Dimitrova; Mendoza Gómez, Ernesto; Tzanov, Tzanko; Francesko, Antonio (2016-09-16)
      Article
      Open Access
      Escherichia coli (E. coli) strains are among the most frequently isolated microorganisms in urinary tract infections able to colonize the surface of urinary catheters and form biofilms. These biofilms are highly resistant ...
    • Inhibition of quorum-sensing: A new paradigm in controlling bacterial virulence and biofilm formation 

      Ivanova, Aleksandra Asenova; Ivanova, Kristina Dimitrova; Tzanov, Tzanko (Springer Nature, 2018-05-31)
      Part of book or chapter of book
      Restricted access - publisher's policy
      Bacterial pathogens coordinate the expression of multiple virulence factors and formation of biofilms in cell density dependent manner, through a phenomenon named quorum sensing (QS). Protected in the biofilm community, ...
    • Innovative approaches for controlling clinically relevant biofilms: current trends and future prospects 

      Ivanova, Kristina Dimitrova; Tzanov, Tzanko; Hoyo Pérez, Javier; Ramon Portés, Eva (2017-01-05)
      Article
      Open Access
      Bacteria that colonize and form biofilms on living tissues and medical devices are a global healthcare concern. They cause life threatening infections and are associated with increased mortality and morbidity in the ...
    • Integrated biofilm dispersion and virulence responsiveness for targeted treatment of pseudomonas aeruginosa infection in lungs 

      Ivanova, Kristina Dimitrova; Ramon Portés, Eva; Wnorowska, Urszula; Todorova, Katerina; Ivanova, Aleksandra Asenova; Bastos-Arrieta, Julio; Puertas Segura, Antonio Jesús; Deptula, Piotr; Damyanova, Tsvetozara; Paunova-Krasteva, Tsvetelina; Bucki, Robert; Ivanov, Ivan; Tzanov, Tzanko (2024-11-12)
      Article
      Open Access
      The self-organization of microbes into biofilms provides multiple benefits including tolerance to mechanical stress and resistance to immune defences and antibiotics. Coupled to a compromised mucociliary function, these ...
    • Interaction of silver-lignin nanoparticles with mammalian mimetic membranes 

      Hoyo Pérez, Javier; Ivanova, Kristina Dimitrova; Torrent Burgués, Juan; Tzanov, Tzanko (Frontiers Media SA, 2020-05-08)
      Article
      Open Access
      Silver nanoparticles (AgNPs) have broad spectrum antibacterial activity, but their toxicity to human cells has raised concerns related to their use as disinfectants or coatings of medically relevant surfaces. To address ...
    • Ionic liquids as biocompatible antibacterial agents: a case study on structure-related bioactivity on Escherichia coli 

      Fernandes, Margarida M.; Carvalho, Estela; Correia, Daniela M.; Esperança, José M.S.S.; Padrão, Jorge; Ivanova, Kristina Dimitrova; Hoyo Pérez, Javier; Tzanov, Tzanko; Lanceros Méndez, Senentxu (American Chemical Society, 2022-10-19)
      Article
      Open Access
      The potential of ionic liquids (ILs) to be used as antimicrobial agents for biomedical applications has been hindered by the fact that most of them are cytotoxic toward mammalian cells. Understanding the mechanism of ...