Browsing by Author "Mateos Timoneda, Miguel Ángel"
Now showing items 1-20 of 31
-
3D bioprinting of biomimetic alginate/gelatin/chondroitin sulfate hydrogel nanocomposites for intrinsically chondrogenic differentiation of human mesenchymal stem cells
(2024-05-10)
Article
Open Access3D-printed hydrogel scaffolds biomimicking the extracellular matrix (ECM) are key in cartilage tissue engineering as they can enhance the chondrogenic differentiation of mesenchymal stem cells (MSCs) through the presence ... -
3D printing as a strategy to scale-up biohybrid hydrogels for T cell manufacture
(2024-01-01)
Article
Open Access
Covenantee: Centro de Investigación Biomédica en Red. Bioingeniería, Biomateriales y Nanomedicina / Universitat Autònoma de Barcelona / Consejo Superior de Investigaciones Científicas / Universitat Internacional de Catalunya / Institut de Bioenginyeria de CatalunyaThe emergence of cellular immunotherapy treatments is introducing more efficient strategies to combat cancer as well as autoimmune and infectious diseases. However, the cellular manufacturing procedures associated with ... -
Advanced binary guanosine and guanosine 5'-monophosphate cell-laden hydrogels for soft tissue reconstruction by 3D bioprinting
(2023-06-28)
Article
Open AccessSoft tissue defects or pathologies frequently necessitate theuse of biomaterials that provide the volume required for subsequentvascularization and tissue formation as autrografts are not always afeasible alternative. ... -
Chondroinductive alginate-based hydrogels having graphene oxide for 3D printed scaffold fabrication
(2020-01-07)
Article
Open AccessScaffolds based on bioconjugated hydrogels are attractive for tissue engineering because they can partly mimic human tissue characteristics. For example, they can further increase their bioactivity with cells. However, ... -
Development and angiogenic potential of cell-derived microtissues using microcarrier-template
(2021-02-25)
Article
Open AccessTissue engineering and regenerative medicine approaches use biomaterials in combination with cells to regenerate lost functions of tissues and organs to prevent organ transplantation. However, most of the current strategies ... -
Development of a novel automatable fabrication method based on electrospinning co electrospraying for rotator cuff augmentation patches
(Public Library of Science (PLOS), 2019-01-01)
Article
Open AccessRotator cuff tear is one of the most common shoulder diseases. Rotator cuff augmentation (RCA) is trying to solve the high retear failure percentage after the surgery procedures (20–90%). The ideal augmentation patch must ... -
Development of a self-assembled peptide/methylcellulose-based bioink for 3D bioprinting
(2019-11-13)
Article
Open AccessThe introduction of 3D bioprinting to fabricate living constructs with tailored architecture has provided a new paradigm for biofabrication, with the potential to overcome several drawbacks of conventional scaffold-based ... -
Development of a three-dimensional bioengineered platform for articular cartilage regeneration
(2020-01-01)
Article
Open AccessDegenerative cartilage pathologies are nowadays a major problem for the world population. Factors such as age, genetics or obesity can predispose people to suffer from articular cartilage degeneration, which involves severe ... -
Development of tailored and self-mineralizing citric acid-crosslinked hydrogels for in situ bone regeneration
(2015-11-01)
Article
Open Access
Covenantee: Universidad de ValladolidBone tissue engineering demands alternatives overcoming the limitations of traditional approaches in the context of a constantly aging global population. In the present study, elastin-like recombinamers hydrogels were ... -
Differential neuronal and glial behavior on flat and micro patterned chitosan films
(2017-10-01)
Article
Open AccessChitosan is a biodegradable natural polysaccharide that has been widely studied for regenerative purposes in the central nervous system. In this study we assessed the in vitro glial and neuronal cells response to chitosan ... -
Disassembling bacterial extracellular matrix with DNase-coated nanoparticles to enhance antibiotic delivery in biofilm infections
(2015-07-10)
Article
Open Access
Covenantee: Hospital Universitari Vall d'HebronInfections caused by biofilm-forming bacteria are a major threat to hospitalized patients and the main cause of chronic obstructive pulmonary disease and cystic fibrosis. There is an urgent necessity for novel therapeutic ... -
Effect of structure, topography and chemistry on fibroblast adhesion and morphology
(2014-07)
Article
Restricted access - publisher's policySurface biofunctionalisation of many biodegradable polymers is one of the used strategies to improve the biological activity of such materials. In this work, the introduction of collagen type I over the surface of a ... -
Engineered microtissues for the bystander therapy against cancer
(Elsevier, 2021-02-01)
Article
Open AccessThymidine kinase expressing human adipose mesenchymal stem cells (TK-hAMSCs) in combination with ganciclovir (GCV) are an effective platform for antitumor bystander therapy in mice models. However, this strategy requires ... -
Engineering cell-derived matrices: from 3D models to advanced personalized therapies
(2020-07-02)
Article
Open AccessRegenerative medicine and disease models have evolved in recent years from two to three dimensions, providing in vitro constructs that are more similar to in vivo tissues. By mimicking native tissues, cell-derived matrices ... -
Enhanced cell-material interactions through the biofunctionalization of polymeric surfaces with engineered peptides
(2013-08)
Article
Restricted access - publisher's policy
Covenantee: Universidad de ValladolidResearch on surface modi fi cation of polymeric materials to guide the cellular activity in biomaterials designed for tissue engineering applications has mostly focused on the use of natural extracellular matrix (ECM) ... -
Hierarchically engineered fibrous scaffolds for bone regeneration
(2013-08-28)
Article
Open AccessSurface properties of biomaterials play a major role in the governing of cell functionalities. It is well known that mechanical, chemical and nanotopo- graphic cues, for example, influence cell proliferation and ... -
Instructive microenvironments in skin wound healing: biomaterials as signal releasing platforms
(2018-04)
Article
Open AccessSkin wound healing aims to repair and restore tissue through a multistage process that involves different cells and signaling molecules that regulate the cellular response and the dynamic remodeling of the extracellular ... -
Modular bioink for 3D printing of biocompatible hydrogels: sol-gel polymerization of hybrid peptides and polymers
(Royal Society of Chemistry, 2017-02-21)
Article
Open AccessAn unprecedented generic system allowing the 3D printing of peptide-functionalized hydrogels by soft sol–gel inorganic polymerization is presented. Hybrid silylated inorganic/bioorganic blocks are mixed in biological buffer ... -
Modular polylactic acid microparticle-based scaffolds prepared via microfluidic emulsion/solvent displacement process: Fabrication, characterization, and in vitro mesenchymal stem cells interaction study
(2012-08-31)
Article
Restricted access - publisher's policyThe present study reports a novel approach for the design and fabrication of polylactic acid (PLA) microparticle- based scaffolds with microstructural properties suitable for bone and cartilage regeneration. Macroporous ... -
Nanotechnology approaches in chronic wound healing
(2020-06-02)
Article
Open AccessSignificance: The incidence of chronic wounds is increasing due to our aging population and the augment of people afflicted with diabetes. With the extended knowledge on the biological mechanisms underlying these diseases, ...
