Browsing by Author "Mateos Timoneda, Miguel Ángel"Més informació

Now showing items 1-20 of 26

    • Chondroinductive alginate-based hydrogels having graphene oxide for 3D printed scaffold fabrication 

      Olate Moya, Felipe; Mateos Timoneda, Miguel Ángel; Engel López, Elisabeth; Arens, Lukas; Wilhelm, Manfred; Palza, Humberto (2020-01-07)
      Article
      Open Access
      Scaffolds based on bioconjugated hydrogels are attractive for tissue engineering because they can partly mimic human tissue characteristics. For example, they can further increase their bioactivity with cells. However, ...

    • Development and angiogenic potential of cell-derived microtissues using microcarrier-template 

      Rubi Sans, Gerard; Cano Garcia, Irene; Pérez Amodio, Soledad Graciela; Blanco, Bárbara; Mateos Timoneda, Miguel Ángel; Engel López, Elisabeth (2021-02-25)
      Article
      Open Access
      Tissue engineering and regenerative medicine approaches use biomaterials in combination with cells to regenerate lost functions of tissues and organs to prevent organ transplantation. However, most of the current strategies ...

    • Development of a novel automatable fabrication method based on electrospinning co electrospraying for rotator cuff augmentation patches 

      Rey Viñoles, Sergi; Castaño Linares, Óscar; Ruiz Macarrilla, Leonardo; Llorens, Xavier; Mora Guix, José M.; Engel López, Elisabeth; Mateos Timoneda, Miguel Ángel (Public Library of Science (PLOS), 2019-01-01)
      Article
      Open Access
      Rotator cuff tear is one of the most common shoulder diseases. Rotator cuff augmentation (RCA) is trying to solve the high retear failure percentage after the surgery procedures (20–90%). The ideal augmentation patch must ...

    • Development of a self-assembled peptide/methylcellulose-based bioink for 3D bioprinting 

      Cofiño, Carla; Pérez Amodio, Soledad Graciela; Semino, Carlos; Engel López, Elisabeth; Mateos Timoneda, Miguel Ángel (2019-11-13)
      Article
      Open Access
      The introduction of 3D bioprinting to fabricate living constructs with tailored architecture has provided a new paradigm for biofabrication, with the potential to overcome several drawbacks of conventional scaffold-based ...

    • Development of a three-dimensional bioengineered platform for articular cartilage regeneration 

      Rubi Sans, Gerard; Recha Sancho, Lourdes; Pérez Amodio, Soledad Graciela; Mateos Timoneda, Miguel Ángel; Semino Margrett, Carlos Eduardo; Engel López, Elisabeth (2020-01-01)
      Article
      Open Access
      Degenerative cartilage pathologies are nowadays a major problem for the world population. Factors such as age, genetics or obesity can predispose people to suffer from articular cartilage degeneration, which involves severe ...

    • Development of tailored and self-mineralizing citric acid-crosslinked hydrogels for in situ bone regeneration 

      Sanchez Ferrero, Aitor; Mata, Álvaro; Mateos Timoneda, Miguel Ángel; Rodriguez Cabello, Jose Carlos; Alonso, Matilde; Planell Estany, Josep Anton; Engel López, Elisabeth (2015-11-01)
      Article
      Open Access
      Covenantee:   Universidad de Valladolid
      Bone tissue engineering demands alternatives overcoming the limitations of traditional approaches in the context of a constantly aging global population. In the present study, elastin-like recombinamers hydrogels were ...

    • Differential neuronal and glial behavior on flat and micro patterned chitosan films 

      Mattotti, Marta; Álvarez Pinto, Zaída; Delgado Muñoz, Luis; Mateos Timoneda, Miguel Ángel; Aparicio, Conrado; Planell Estany, Josep Anton; Alcántara Horrillo, Soledad; Engel López, Elisabeth (2017-10-01)
      Article
      Open Access
      Chitosan is a biodegradable natural polysaccharide that has been widely studied for regenerative purposes in the central nervous system. In this study we assessed the in vitro glial and neuronal cells response to chitosan ...

    • Disassembling bacterial extracellular matrix with DNase-coated nanoparticles to enhance antibiotic delivery in biofilm infections 

      Baelo, Aida; Levato, Riccardo; Julian, Esther; Crespo, A.; Astola, Jose; Gavalda, Joan; Engel López, Elisabeth; Mateos Timoneda, Miguel Ángel; Torrents, Eduard (2015-07-10)
      Article
      Open Access
      Covenantee:   Hospital Universitari Vall d'Hebron
      Infections caused by biofilm-forming bacteria are a major threat to hospitalized patients and the main cause of chronic obstructive pulmonary disease and cystic fibrosis. There is an urgent necessity for novel therapeutic ...

    • Effect of structure, topography and chemistry on fibroblast adhesion and morphology 

      Mateos Timoneda, Miguel Ángel; Castaño Linares, Óscar; Planell Estany, Josep Anton; Engel López, Elisabeth (2014-07)
      Article
      Restricted access - publisher's policy
      Surface biofunctionalisation of many biodegradable polymers is one of the used strategies to improve the biological activity of such materials. In this work, the introduction of collagen type I over the surface of a ...

    • Engineered microtissues for the bystander therapy against cancer 

      Blanco Fernández, Bárbara; Cano Torres, Irene; Garrido, Cristina; Rubi Sans, Gerard; Sanchez Cid, Lourdes; Guerra Rebollo, Marta; Rubio, Nuria; Blanco, Jeronimo; Pérez Amodio, Soledad Graciela; Mateos Timoneda, Miguel Ángel; Engel López, Elisabeth (Elsevier, 2021-02-01)
      Article
      Open Access
      Thymidine kinase expressing human adipose mesenchymal stem cells (TK-hAMSCs) in combination with ganciclovir (GCV) are an effective platform for antitumor bystander therapy in mice models. However, this strategy requires ...

    • Engineering cell-derived matrices: from 3D models to advanced personalized therapies 

      Rubi Sans, Gerard; Castaño Linares, Óscar; Cano Torres, Irene; Mateos Timoneda, Miguel Ángel; Pérez Amodio, Soledad Graciela; Engel López, Elisabeth (2020-07-02)
      Article
      Open Access
      Regenerative medicine and disease models have evolved in recent years from two to three dimensions, providing in vitro constructs that are more similar to in vivo tissues. By mimicking native tissues, cell-derived matrices ...

    • Enhanced cell-material interactions through the biofunctionalization of polymeric surfaces with engineered peptides 

      Punet, Xavier; Mauchauffé, Rodolphe; Giannotti, Marina I.; Rodriguez Cabello, Jose Carlos; Sanz Carrasco, Fausto; Engel López, Elisabeth; Mateos Timoneda, Miguel Ángel; Planell Estany, Josep Anton (2013-08)
      Article
      Restricted access - publisher's policy
      Covenantee:   Universidad de Valladolid
      Research on surface modi fi cation of polymeric materials to guide the cellular activity in biomaterials designed for tissue engineering applications has mostly focused on the use of natural extracellular matrix (ECM) ...

    • Hierarchically engineered fibrous scaffolds for bone regeneration 

      Sachot, Nadège; Castaño Linares, Óscar; Mateos Timoneda, Miguel Ángel; Engel López, Elisabeth; Planell Estany, Josep Anton (2013-08-28)
      Article
      Open Access
      Surface properties of biomaterials play a major role in the governing of cell functionalities. It is well known that mechanical, chemical and nanotopo- graphic cues, for example, influence cell proliferation and ...

    • Instructive microenvironments in skin wound healing: biomaterials as signal releasing platforms 

      Castaño, Óscar; Pérez Amodio, Soledad Graciela; Navarro Requena, Claudia; Mateos Timoneda, Miguel Ángel; Engel López, Elisabeth (2018-04)
      Article
      Open Access
      Skin wound healing aims to repair and restore tissue through a multistage process that involves different cells and signaling molecules that regulate the cellular response and the dynamic remodeling of the extracellular ...

    • Modular bioink for 3D printing of biocompatible hydrogels: sol-gel polymerization of hybrid peptides and polymers 

      Echalier, Cecile; Levato, Riccardo; Mateos Timoneda, Miguel Ángel; Castaño Linares, Óscar; Dejean, S; Garric, X; Pinese, C; Noël, D; Engel López, Elisabeth; Martinez, J; Mehdi, A; Subra, Gilles (Royal Society of Chemistry, 2017-02-21)
      Article
      Open Access
      An unprecedented generic system allowing the 3D printing of peptide-functionalized hydrogels by soft sol–gel inorganic polymerization is presented. Hybrid silylated inorganic/bioorganic blocks are mixed in biological buffer ...

    • Modular polylactic acid microparticle-based scaffolds prepared via microfluidic emulsion/solvent displacement process: Fabrication, characterization, and in vitro mesenchymal stem cells interaction study 

      Salerno, Aurelio; Levato, R.; Mateos Timoneda, Miguel Ángel; Engel López, Elisabeth; Netti, Paolo Antonio; Planell Estany, Josep Anton (2012-08-31)
      Article
      Restricted access - publisher's policy
      The present study reports a novel approach for the design and fabrication of polylactic acid (PLA) microparticle- based scaffolds with microstructural properties suitable for bone and cartilage regeneration. Macroporous ...

    • Nanotechnology approaches in chronic wound healing 

      Blanco Fernández, Bárbara; Castaño, Óscar; Mateos Timoneda, Miguel Ángel; Engel López, Elisabeth; Pérez Amodio, Soledad Graciela (2020-06-02)
      Article
      Open Access
      Significance: The incidence of chronic wounds is increasing due to our aging population and the augment of people afflicted with diabetes. With the extended knowledge on the biological mechanisms underlying these diseases, ...

    • Neurogenesis and vascularization of the damaged brain using a lactate-releasing biomimetic scaffold 

      Álvarez Pinto, Zaída; Castaño Linares, Óscar; Castells, Alba; Mateos Timoneda, Miguel Ángel; Planell Estany, Josep Anton; Engel López, Elisabeth; Alcántara, Soledad (2014-06)
      Article
      Restricted access - publisher's policy
      Regenerative medicine strategies to promote recovery following traumatic brain injuries are currently focused on the use of biomaterials as delivery systems for cells or bioactive molecules. This study shows that cell-free ...

    • Poly-L/DL-lactic acid films functionalized with collagen IV as carrier substrata for corneal epithelial stem cells 

      de la Mata Sampedro, Ana; Mateos Timoneda, Miguel Ángel; Nieto Miguel, Teresa; Galindo de la Rosa, Sara; López Paniagua, Marina; Planell Estany, Josep Anton; Engel López, Elisabeth; Calonge Cano, Margarita (2019-05-01)
      Article
      Open Access
      Limbal epithelial stem cells (LESCs) are responsible for the renewal of corneal epithelium. Cultivated limbal epithelial transplantation is the current treatment of choice for restoring the loss or dysfunction of LESCs. ...

    • Polylactic acid organogel as versatile scaffolding technique 

      Punet, Xavier; Levato, Riccardo; Bataille, Isabelle; Letourneur, Didier; Engel López, Elisabeth; Mateos Timoneda, Miguel Ángel (Elsevier, 2017-03-24)
      Article
      Open Access
      Tissue engineering requires scaffolding techniques based on non-toxic processes that permits the fabrication of constructs with tailored properties. Here, a two-step methodology based on the gelation and precipitation of ...