Now showing items 1-11 of 11

  • Ageing is associated with deterioration of calcium homeostasis in isolated human right atrial myocytes 

    Herrainz, Adela; Álvarez-García, Jesus; Llach, A; Molina, Cristina E.; Fernandes, Jacqueline; Ferrero-Gregori, Andreu; Rodríguez, Cristina; Vallmitjana Lees, Alex; Benítez Iglesias, Raúl; Padró, Josep M.; Martínez-González, José; Cinca Cosculluela, Juan; Hove-Madsen, Leif (2015-02-24)
    Article
    Open Access
    Ageing-related cardiac disorders such as heart failure and atrial fibrillation often present with intracellular calcium homeostasis dysfunction. However, knowledge of the intrinsic effects of ageing on cellular calcium ...
  • Are SR Ca content fluctuations or SR refractoriness the key to atrial cardiac alternans?: insights from a human atrial model 

    Lugo Vélez, Carlos Antonio; Rodríguez Cantalapiedra, Inma; Peñaranda Ayllón, Angelina; Hove-Madsen, Leif; Echebarría Domínguez, Blas (2014-06-01)
    Article
    Restricted access - publisher's policy
    Despite the important role of electromechanical alternans in cardiac arrhythmogenesis, its molecular origin is not well understood. The appearance of calcium alternans has often been associated to fluctuations in the ...
  • Dependency of calcium alternans on Ryanodine Receptor Refractoriness 

    Álvarez Lacalle, Enrique; Rodríguez Cantalapiedra, Inma; Peñaranda Ayllón, Angelina; Cinca, J.; Hove-Madsen, Leif; Echebarría Domínguez, Blas (2013-02-04)
    Article
    Open Access
    Background Rapid pacing rates induce alternations in the cytosolic calcium concentration caused by fluctuations in calcium rele However, the relationship between calcium alternans and refractoriness of the SR calcium ...
  • Detection, properties, and frequency of local calcium release from the sarcoplasmic reticulum in teleost cardiomyocytes 

    Llach, Anna; Molina, Cristina E.; Álvarez Lacalle, Enrique; Tort, Lluis; Benítez Iglesias, Raúl; Hove-Madsen, Leif (2011-08-29)
    Article
    Open Access
    Calcium release from the sarcoplasmic reticulum (SR) plays a central role in the regulation of cardiac contraction and rhythm in mammals and humans but its role is controversial in teleosts. Since the zebrafish is an ...
  • Effect of RyR2 refractoriness and hypercalcemia on calcium overload, spontaneous release, and calcium alternans 

    Álvarez Lacalle, Enrique; Peñaranda Ayllón, Angelina; Rodríguez Cantalapiedra, Inma; Hove-Madsen, Leif; Echebarría Domínguez, Blas (2013)
    Article
    Restricted access - publisher's policy
    In this work we use a computer model of a ventricular rabbit myocyte to study several factors that affect sarcoplasmic reticulum (SR) calcium load, such as hypercalcemia, SR calcium buffering, or ryanodine receptor ...
  • Identification of intracellular calcium dynamics in stimulated cardiomyocytes 

    Vallmitjana Lees, Alex; Barriga, Montserrat; Nenadic, Zoran; Llach, Anna; Álvarez Lacalle, Enrique; Hove-Madsen, Leif; Benítez Iglesias, Raúl (IEEE Press. Institute of Electrical and Electronics Engineers, 2010)
    Conference report
    Open Access
    We have developed an automatic method for the analysis and identification of dynamical regimes in intracellular calcium patterns from confocal calcium images. The method allows the identification of different dynamical ...
  • Low density lipoproteins promote unstable calcium handling accompanied by reduced SERCA2 and connexin-40 expression in cardiomyocytes 

    Barriga, Montserrat; Cal, Roi; Cabello, Nuria; Llach, Anna; Vallmitjana Lees, Alex; Benítez Iglesias, Raúl; Badimón, Lina; Cinca, J.; Llorente-Cortés, Vicenta; Hove-Madsen, Leif (2013-03-13)
    Article
    Open Access
    The damaging effects of high plasma levels of cholesterol in the cardiovascular system are widely known, but little attention has been paid to direct effects on cardiomyocyte function. We therefore aimed at testing the ...
  • Modeling calcium dynamics in human atria 

    Rodríguez Cantalapiedra, Inma; Lugo Vélez, Carlos Antonio; Peñaranda Ayllón, Angelina; Hove-Madsen, Leif; Echebarría Domínguez, Blas (2014-01-02)
    Article
    Restricted access - publisher's policy
    Mathematical models of cardiac electrophysiology are an important tool to investigate the underlying mecha- nisms responsible of arrhythmias. In particular, an im- portant question is the origin of atrial fibrillation ...
  • Multilevel analysis of calcium dynamics in stimulated cultures of cardiomyocytes 

    Vallmitjana Lees, Alex; Hove-Madsen, Leif; Barriga, Montserrat; Benítez Iglesias, Raúl (Institute of Electrical and Electronics Engineers (IEEE), 2013)
    Conference report
    Restricted access - publisher's policy
    We present an automatic method to characterize calcium activity in a culture of cardiac cells from a sequence of microscopy fluorescence images. The approach quantifies both the response of each individual cell in the ...
  • Nonlinearities due to refractoriness in SR Ca release 

    Peñaranda Ayllón, Angelina; Álvarez Lacalle, Enrique; Rodríguez Cantalapiedra, Inma; Hove-Madsen, Leif; Echebarría Domínguez, Blas (2012)
    Conference lecture
    Open Access
    Calcium alternans is a pro-arrhytmic cardiac dysfunction related to beat-to-beat changes in the amplitude of intracellular calcium transient, that typically occurs at rapid pacing rates. Although oscillations in sarcoplasmic ...
  • Phospholamban knockout breaks arrhythmogenic Ca2+ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice 

    Bai, Yunlong; Jones, Peter; Guo, Jiqing; Zhong, Xiaowei; Clark, Robert; Zhou, Qiang; Wang, Ruiwu; Vallmitjana Lees, Alex; Benítez Iglesias, Raúl; Hove-Madsen, Leif; Semeniuk, Lisa; Guo, Ang; Song, Long-Sheng; Duff, Henry J.; Chen, S.R. Wayne (2013-07-15)
    Article
    Restricted access - publisher's policy
    Rationale: Phospholamban (PLN) is an inhibitor of cardiac sarco(endo)plasmic reticulum Ca2+ ATPase. PLN knockout (PLN-KO) enhances sarcoplasmic reticulum Ca2+ load and Ca2+ leak. Conversely, PLN-KO accelerates Ca2+ ...