Browsing by Author "Macovez, Roberto"
Now showing items 1-20 of 47
-
A facile approach to hydrophilic oxidized fullerenes and their derivatives as cytotoxic agents and supports for nanobiocatalytic systems
(Nature, 2020-12-01)
Article
Open AccessA facile, environment-friendly, versatile and reproducible approach to the successful oxidation of fullerenes (oxC60) and the formation of highly hydrophilic fullerene derivatives is introduced. This synthesis relies on ... -
Amorphous binary dispersions of chloramphenicol in enantiomeric pure and racemic poly-lactic acid: morphology, molecular relaxations, and controlled drug release
(2019-09-10)
Article
Open AccessWe study amorphous solid dispersions (ASDs) of the chloramphenicol antibiotic in two biodegradable polylactic acid polymers, namely a commercial sample of enantiomeric pure PLLA and a home-synthesized PDLLA copolymer, to ... -
Amorphous solid dispersions of curcumin in a poly(ester amide): antiplasticizing effect on the glass transition and macromolecular relaxation dynamics, and controlled release
(2023-09)
Article
Open AccessIn order to exploit the pharmacological potential of natural bioactive molecules with low water solubility, such as curcumin, it is necessary to develop formulations, such as amorphous polymer dispersions, which allow a ... -
C60 solvate with (1,1,2)-trichloroethane: dynamic statistical disorder and mixed conformation
(2016-05-27)
Article
Open AccessWe present a full characterization of the orientationally disordered cocrystal of C-60 with (1,1,2)-triChloroethane (C2H3Cl3), by means of X-ray diffraction, Raman spectroscopy, and broadband dielectric spectroscopy. Our ... -
Chloramphenicol loaded polylactide melt electrospun scaffolds for biomedical applications
(2021-09-05)
Article
Open AccessMelt electrospinning of polylactide (PLA) loaded with chloramphenicol (CAM) has been performed and characteristics of fibers, physical properties of scaffolds, CAM release behavior, antibacterial properties and biocompatibility ... -
Collective relaxation dynamics and crystallization kinetics of the amorphous Biclotymol antiseptic
(2015-11-10)
Article
Open AccessWe employ dielectric spectroscopy to monitor the relaxation dynamics and crystallization kinetics of the Biclotymol antiseptic in its amorphous phase. The glass transition temperature of the material as determined by ... -
Comparative physical study of three pharmaceutically active benzodiazepine derivatives: crystalline versus amorphous state and crystallization tendency
(American Chemical Society, 2021-01-01)
Article
Open AccessChemical derivatization and amorphization are two possible strategies to improve the solubility and bioavailability of drugs, which is a key issue for the pharmaceutical industry. In this contribution, we explore whether ... -
Curs 0: preparació per als estudis a l’EEBE
(Universitat Politècnica de Catalunya. Institut de Ciències de l'Educació, 2022-05)
Article
Open AccessAquest article presenta el desenvolupament i primers resultats d'ús d'un conjunt de cursos virtuals que pretenen proporcionar uns coneixements inicials bàsics de Matemàtiques, Física i !ímica als estudiants que accedeixen ... -
Double primary relaxation in a highly anisotropic orientational glass-former with low-dimensional disorder
(2016-04-26)
Article
Open AccessThe freezing of the cooperative reorientational motions in orientationally disordered (OD) molecular crystals marks the so-called \glassy" transition, which may be considered a lower-dimensional version of the structural ... -
Drug-biopolymer dispersions: morphology-and temperature-dependent (anti)plasticizer effect of the drug and component-specific Johari–Goldstein relaxations
(2022-03-01)
Article
Open AccessAmorphous molecule-macromolecule mixtures are ubiquitous in polymer technology and are one of the most studied routes for the development of amorphous drug formulations. For these applications it is crucial to understand ... -
Enhancement of the physical and chemical stability of amorphous drug-polymer mixtures via cryogenic comilling
(American Chemical Society (ACS), 2018-11-27)
Article
Open AccessAmorphous dispersions of the Biclotymol antiseptic are obtained in polyvinylpyrrolidone (PVP), for different drug loadings, by comilling at temperatures below the glass transition of both components. Characterization of ... -
Eutectic mixture formation and relaxation dynamics of coamorphous mixtures of two benzodiazepine drugs
(Multidisciplinary Digital Publishing Institute (MDPI), 2023-01-01)
Article
Open AccessThe formation of coamorphous mixtures of pharmaceuticals is an interesting strategy to improve the solubility and bioavailability of drugs, while at the same time enhancing the kinetic stability of the resulting binary ... -
Formulation and characterization of mucoadhesive controlled release matrix tablets of captopril
(2017-12-01)
Article
Open AccessThe purpose of this study is to characterize controlled release matrix tablets of captopril and to find out the physicochemical properties that have an effect on the mucoadhesion process. The hydrophilic matrix tablets ... -
Genuine antiplasticizing effect of water on a glass-former drug
(Macmillan Publishers, 2017-08-07)
Article
Open AccessWater is the most important plasticizer of biological and organic hydrophilic materials, which generally exhibit enhanced mechanical softness and molecular mobility upon hydration. The enhancement of the molecular dynamics ... -
Glass transition, crystallization kinetics, and inter-conformer relaxation dynamics of amorphous mitotane and related compounds
(Elsevier, 2022-12-15)
Article
Open AccessWe employ differential scanning calorimetry, broadband dielectric spectroscopy and optical microscopy to investigate the glass transition, molecular relaxation dynamics, and isothermal recrystallization kinetics of amorphous ... -
Hopping conductivity and polarization effects in a fullerene derivative salt
(2014-06-12)
Article
Restricted access - publisher's policyImpedance spectroscopy is employed to probe the frequency-dependent conductivity and dielectric response of the C60O24Na 24 fulleride. The conduction properties of this organic material match the so-called universal behavior ... -
Inter-enantiomer conversion dynamics and Johari–Goldstein relaxation of benzophenones
(Nature, 2021-10-12)
Article
Open AccessWe employ temperature- and pressure-dependent dielectric spectroscopy, as well as differential scanning calorimetry, to characterize benzophenone and the singly-substituted ortho-bromobenzophenone derivative in the liquid ... -
Measurement of the dispersion of air and of refractive index anomalies by wavelength- dependent nonlinear interferometry
(2009-07-27)
Article
Open AccessWe carry out wavelength-dependent second harmonic interference experiments using thin films of an organic dye as nonlinear optical sources. While the measured difference of refractive index between the fundamental and ... -
Mixtures of m-fluoroaniline with apolar aromatic molecules: Phase behaviour, suppression of H-bonded clusters, and local H-bond relaxation dynamics
(2019-12-15)
Article
Open AccessWe employ differential scanning calorimetry, IR spectroscopy, X-ray powder diffraction and dielectric spectroscopy to characterize binary mixtures of m-fluoroaniline (mFA), a rigid-molecule glass former, with two ... -
Molecular conformation in organic films from quantum chemistry ab initio calculations and second harmonic spectroscopy
(2012-11-30)
Article
Restricted access - publisher's policyIdentifying molecular species and conformations at surfaces is of interest for both catalytic and biointerfacial research. Here, we present an extinction and second harmonic spectroscopy study of films of crystal violet ...
