Browsing by Author "Macovez, Roberto"
Now showing items 1-20 of 42
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A facile approach to hydrophilic oxidized fullerenes and their derivatives as cytotoxic agents and supports for nanobiocatalytic systems
Zygouri, Panagiota; Spyrou, Konstantinos; Mitsari, Efstratia; Barrio Casado, María del; Macovez, Roberto; Patila, Michaela; Stamatis, Haralambo; Verginadis, Ioannis; Velalopoulou, Anastasia; Evangelou, Angelos; Sideratou, Zili; Gournis, Dimitrios; Rudolf, Petra (Nature, 2020-12-01)
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Open AccessA facile, environment-friendly, versatile and reproducible approach to the successful oxidation of fullerenes (oxC60) and the formation of highly hydrophilic fullerene derivatives is introduced. This synthesis relies on ... -
Amorphous binary dispersions of chloramphenicol in enantiomeric pure and racemic poly-lactic acid: morphology, molecular relaxations, and controlled drug release
Valenti, Sofia; Díaz Andrade, Angélica María; Romanini, Michela; Valle Mendoza, Luis Javier del; Puiggalí Bellalta, Jordi; Tamarit Mur, José Luis; Macovez, Roberto (2019-09-10)
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Open AccessWe study amorphous solid dispersions (ASDs) of the chloramphenicol antibiotic in two biodegradable polylactic acid polymers, namely a commercial sample of enantiomeric pure PLLA and a home-synthesized PDLLA copolymer, to ... -
C60 solvate with (1,1,2)-trichloroethane: dynamic statistical disorder and mixed conformation
Mitsari, Efstratia; Romanini, Michela; Qureshi, Navid; Tamarit Mur, José Luis; Barrio Casado, María del; Macovez, Roberto (2016-05-27)
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Open AccessWe present a full characterization of the orientationally disordered cocrystal of C-60 with (1,1,2)-triChloroethane (C2H3Cl3), by means of X-ray diffraction, Raman spectroscopy, and broadband dielectric spectroscopy. Our ... -
Chloramphenicol loaded polylactide melt electrospun scaffolds for biomedical applications
Valenti, Sofia; Valle Mendoza, Luis Javier del; Yousefzade, Omid; Macovez, Roberto; Franco García, María Lourdes; Puiggalí Bellalta, Jordi (2021-09-05)
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Restricted access - publisher's policyMelt electrospinning of polylactide (PLA) loaded with chloramphenicol (CAM) has been performed and characteristics of fibers, physical properties of scaffolds, CAM release behavior, antibacterial properties and biocompatibility ... -
Collective relaxation dynamics and crystallization kinetics of the amorphous Biclotymol antiseptic
Tripathi, Pragya; Romanini, Michela; Tamarit Mur, José Luis; Macovez, Roberto (2015-11-10)
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Open AccessWe employ dielectric spectroscopy to monitor the relaxation dynamics and crystallization kinetics of the Biclotymol antiseptic in its amorphous phase. The glass transition temperature of the material as determined by ... -
Comparative physical study of three pharmaceutically active benzodiazepine derivatives: crystalline versus amorphous state and crystallization tendency
Valenti, Sofia; Barrio Casado, María del; Negrier, Philippe; Romanini, Michela; Macovez, Roberto; Tamarit Mur, José Luis (American Chemical Society, 2021-01-01)
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Restricted access - publisher's policyChemical derivatization and amorphization are two possible strategies to improve the solubility and bioavailability of drugs, which is a key issue for the pharmaceutical industry. In this contribution, we explore whether ... -
Double primary relaxation in a highly anisotropic orientational glass-former with low-dimensional disorder
Romanini, Michela; Barrio Casado, María del; Capaccioli, Simon; Ruíz Martín, María Dolores; Macovez, Roberto; Tamarit Mur, José Luis (2016-04-26)
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Open AccessThe freezing of the cooperative reorientational motions in orientationally disordered (OD) molecular crystals marks the so-called \glassy" transition, which may be considered a lower-dimensional version of the structural ... -
Enhancement of the physical and chemical stability of amorphous drug-polymer mixtures via cryogenic comilling
Romanini, Michela; Lorente, Marta; Schammé, Benjamin; Delbreilh, Laurent; Dupray, Valérie; Coquerel, Gerard; Tamarit Mur, José Luis; Macovez, Roberto (American Chemical Society (ACS), 2018-11-27)
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Open AccessAmorphous dispersions of the Biclotymol antiseptic are obtained in polyvinylpyrrolidone (PVP), for different drug loadings, by comilling at temperatures below the glass transition of both components. Characterization of ... -
Formulation and characterization of mucoadhesive controlled release matrix tablets of captopril
Saurí, J.; Zachariah, Manesh; Macovez, Roberto; Tamarit Mur, José Luis; Millán, Daniel; Suñé Pou, M.; García Montoya, E.; Pérez Lozano, P.; Miñarro, M.; Ticó, J. R.; Suñé Negr, J. M. (2017-12-01)
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Open AccessThe purpose of this study is to characterize controlled release matrix tablets of captopril and to find out the physicochemical properties that have an effect on the mucoadhesion process. The hydrophilic matrix tablets ... -
Genuine antiplasticizing effect of water on a glass-former drug
Ruiz Tabbia, Guadalupe Natalia; Romanini, Michela; Hauptmann, Astrid; Loerting, Thomas; Shalaev, Evgenyi; Tamarit Mur, José Luis; Pardo Soto, Luis Carlos; Macovez, Roberto (Macmillan Publishers, 2017-08-07)
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Open AccessWater is the most important plasticizer of biological and organic hydrophilic materials, which generally exhibit enhanced mechanical softness and molecular mobility upon hydration. The enhancement of the molecular dynamics ... -
Hopping conductivity and polarization effects in a fullerene derivative salt
Macovez, Roberto; Zachariah, Manesh; Romanini, Michela; Zygouri, Panagiota; Gournis, Dimitrios; Tamarit Mur, José Luis (2014-06-12)
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Restricted access - publisher's policyImpedance spectroscopy is employed to probe the frequency-dependent conductivity and dielectric response of the C60O24Na 24 fulleride. The conduction properties of this organic material match the so-called universal behavior ... -
Inter-enantiomer conversion dynamics and Johari–Goldstein relaxation of benzophenones
Romanini, Michela; Macovez, Roberto; Tamarit Mur, José Luis (Nature, 2021-10-12)
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Open AccessWe employ temperature- and pressure-dependent dielectric spectroscopy, as well as differential scanning calorimetry, to characterize benzophenone and the singly-substituted ortho-bromobenzophenone derivative in the liquid ... -
Measurement of the dispersion of air and of refractive index anomalies by wavelength- dependent nonlinear interferometry
Macovez, Roberto; Mariano, Marina; Di Finizio, Sergio; Martorell Pena, Jordi (2009-07-27)
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Open AccessWe carry out wavelength-dependent second harmonic interference experiments using thin films of an organic dye as nonlinear optical sources. While the measured difference of refractive index between the fundamental and ... -
Mixtures of m-fluoroaniline with apolar aromatic molecules: Phase behaviour, suppression of H-bonded clusters, and local H-bond relaxation dynamics
Romanini, Michela; Barrio Casado, María del; Macovez, Roberto; Capaccioli, Simon; Tamarit Mur, José Luis (2019-12-15)
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Open AccessWe employ differential scanning calorimetry, IR spectroscopy, X-ray powder diffraction and dielectric spectroscopy to characterize binary mixtures of m-fluoroaniline (mFA), a rigid-molecule glass former, with two ... -
Molecular conformation in organic films from quantum chemistry ab initio calculations and second harmonic spectroscopy
Macovez, Roberto; López, Núria; Mariano, Marina; Maymó Camós, Marc; Martorell Pena, Jordi (2012-11-30)
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Restricted access - publisher's policyIdentifying molecular species and conformations at surfaces is of interest for both catalytic and biointerfacial research. Here, we present an extinction and second harmonic spectroscopy study of films of crystal violet ... -
Molecular diffusion and dc conductivity perfectly correlated with molecular rotational dynamics in a plastic crystalline electrolyte
Zachariah, Manesh; Romanini, Michela; Tripathi, Pragya; Tamarit Mur, José Luis; Macovez, Roberto (2015-01-01)
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Molecular ¿(2) gratings via electron-beam lithography
Domínguez Juárez, Jorge Luis; Macovez, Roberto; Gonzalez, M.U.; Martorell Pena, Jordi (2010-07)
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Restricted access - publisher's policyWe show that the nonlinear optical activity of an organic molecule may be quenched by electron irradiation. Exploiting this effect, we inscribe periodic χ(2) patterns in the molecular films by means of a scanning electron ... -
New approaches for the fabrication of photonic structures of nonlinear optical materials
Carvajal, J J; Peña, A; Kumar, R.; Pujol, M. C.; Mateos, X.; Aguiló Díaz, Magdalena; Díaz, F; Vázquez De Aldana, J. R.; Méndez, Carlos Alberto; Moreno, P; Roso, L; Todorov Trifonov, Trifon; Rodríguez Martínez, Ángel; Alcubilla González, Ramón; Král, Z; Ferré Borrull, J.; Pallarès Marzal, Josep; Marsal, L F; Finizio, Sergio Di; Martorell Pena, Jordi; Macovez, Roberto (2009-12)
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Restricted access - publisher's policyWe revisited two different strategies to fabricate 1D photonic crystals of nonlinear optical dielectric materials based on ultrafast laser ablation of the surface of an RbTiOPO4 crystal, and selective etching of ferroelectric ... -
Nose temperature and anticorrelation between recrystallization kinetics and molecular relaxation dynamics in amorphous morniflumate at high pressure
Romanini, Michela; Valenti, Sofia; Barrio Casado, María del; Tamarit Mur, José Luis; Macovez, Roberto; Rodríguez Martín, Sergio (2019-07-05)
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Open AccessWe probe the dielectric response of the supercooled liquid phase of Morniflumate, a drug with anti-inflammatory and antipyretic properties, studying in particular the pressure and temperature dependence of the relaxation ... -
On the microscopic origin of the cryoprotective effect in lysine solutions
Henao, Andrés; Ruiz Tabbia, Guadalupe Natalia; Steinke, Nicola; Cerveny Murcia, Silvina; Macovez, Roberto; Busch, Sebastian; McLain, Sylvia E.; Lorenz, Christian D.; Pardo Soto, Luis Carlos (2020-04-07)
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Open AccessThe amino acid lysine has been shown to prevent water crystallization at low temperatures in saturated aqueous solutions [S. Cerveny and J. Swenson, Phys. Chem. Chem. Phys., 2014, 16, 22382–22390]. Here, we investigate two ...