The paper describes a mechanical model of epithelial tissue development in Drosophila embryos to investigate a buckling phenomenon called invagination. The finite element method is used to model this ventral furrow formation ...

Optimal control theory allows finding the optimal input of a mechanical system modelled as an initial value problem. The resulting minimisation problem may be solved with known direct and indirect methods. We propose time ...

Wound healing is a biological mechanism that allows the integrity and functionality of tissues to be preserved. Dr Jose Muñoz, Associate Professor at the Laboratory of Numerical Analysis (LaCàN), Universitat Politècnica ...

We resort to non-linear viscoelasticity to develop a truss element able to model reversible softening in lung epithelial tissues undergoing transient stretch. Such a Maxwell truss element is built by resorting to a ...

n this paper we present a method for decomposing a class of convex nonlinear programmes which are frequently encountered in engineering plastic analysis. These problems have second-order conic memberships constraints and ...

Despite the recent progress in optimisation techniques, finite-element stability analysis of realistic three-dimensional problems is still hampered by the size of the resulting optimisation problem. Current solvers may ...

Soft active tissues exhibit softening, hardening, and reversible fluidisation. The result of these non-linear behaviour is due to multiple processes taking part at different scales: active protein motors that actuate at ...

The ability of cells to follow gradients of extracellular matrix stiffness—durotaxis—has been implicated in development, fibrosis, and cancer. Here, we found multicellular clusters that exhibited durotaxis even if isolated ...

We present a least-squares based inverse analysis of visco-elastic biological tissues. The proposed method computes the set of contractile forces (dipoles) at the cell boundaries that induce the observed and quantified ...