Exploració per autor "Lupala, Cecylia Severin"
Ara es mostren els items 1-8 de 8
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Discovery of new selective antagonists of G-protein coupled receptors of therapeutic interest
Lupala, Cecylia Severin (Universitat Politècnica de Catalunya, 2016-01-28)
Tesi
Accés obertGPCR are integral membrane receptor proteins that are characterized by heptahelical transmembrane domains connected by intracellular and extracellular loops. GPCRs are an attractive class of proteins for drug discovery, ... -
Flavonoid allosteric modulation of mutated visual rhodopsin associated with retinitis pigmentosa
Herrera Hernández, María Guadalupe; Ramon Portés, Eva; Lupala, Cecylia Severin; Tena Campos, Mercè; Pérez González, Juan Jesús; Garriga Solé, Pere (Macmillan Publishers, 2017-12-01)
Article
Accés obertDietary flavonoids exhibit many biologically-relevant functions and can potentially have beneficial effects in the treatment of pathological conditions. In spite of its well known antioxidant properties, scarce structural ... -
Molecular determinants of the bacterial resistance to fluoroquinolones: A computational study
Lupala, Cecylia Severin; Gómez Gutiérrez, Patricia; Pérez González, Juan Jesús (2013-06-13)
Article
Accés obertAbstract: Quinolones constitute a large class of antibacterial agents whose action is mediated through the formation of a ternary complex with DNA and either, DNA Gyrase or topoisomerase IV, resulting in the inhibition ... -
New insights into the stereochemical requirements of the bradykinin B1 receptor antagonist binding
Pérez González, Juan Jesús; Lupala, Cecylia Severin; Gomez-Gutierrez, Patricia (2016-07-21)
Article
Accés obertBradykinin (BK) is a nonapeptide involved in several pathophysiological conditions including among others, septic and haemorrhagic shock, anaphylaxis, arthritis, rhinitis, asthma, inflammatory bowel disease. Accordingly, ... -
New insights into the stereochemical requirements of the bradykinin B1 receptor antagonist binding.
Lupala, Cecylia Severin; Gomez-Gutierrez, Patricia; Pérez González, Juan Jesús (2016-07-26)
Article
Accés obertBradykinin (BK) is a nonapeptide involved in several pathophysiological conditions including among others, septic and haemorrhagic shock, anaphylaxis, arthritis, rhinitis, asthma, inflammatory bowel disease. Accordingly, ... -
New insights into the stereochemical requirements of the bradykinin B2 receptor antagonists binding
Lupala, Cecylia Severin; Gomez-Gutierrez, Patricia; Pérez González, Juan Jesús (2016-01-20)
Article
Accés obertBradykinin (BK) is a member of the kinin family, released in response to inflammation, trauma, burns, shock, allergy and some cardiovascular diseases, provoking vasodilatation and increased vascular permeability among other ... -
Using molecular dynamics for the refinement of atomistic models of GPCRs by homology modeling
Lupala, Cecylia Severin; Rasaeifar, Bahareh; Gómez Gutiérrez, Patricia; Pérez González, Juan Jesús (2017-08-13)
Article
Accés obertDespite GPCRs sharing a common seven helix bundle, analysis of the diverse crystallographic structures available reveal specific features that might be relevant for ligand design. Despite the number of crystallographic ... -
Zinc is involved in depression by modulating G-protein-coupled receptor heterodimerization
Tena Campos, Mercè; Ramon Portés, Eva; Lupala, Cecylia Severin; Pérez González, Juan Jesús; Koch, Karl-Wilhelm; Garriga Solé, Pere (2016-04)
Article
Accés obert5-Hydroxytryptamine 1A receptor and galanin receptor 1 belong to the G protein-coupled receptors superfamily, and they have been described to heterodimerize triggering an anomalous physiological state that would underlie ...