Now showing items 1-8 of 8

  • Ageing is associated with deterioration of calcium homeostasis in isolated human right atrial myocytes 

    Herrainz, Adela; Álvarez-García, Jesus; Llach, A; Molina, Cristina E.; Fernandes, Jacqueline; Ferrero-Gregori, Andreu; Rodríguez, Cristina; Vallmitjana Lees, Alex; Benítez Iglesias, Raúl; Padró, Josep M.; Martínez-González, José; Cinca Cosculluela, Juan; Hove-Madsen, Leif (2015-02-24)
    Article
    Open Access
    Ageing-related cardiac disorders such as heart failure and atrial fibrillation often present with intracellular calcium homeostasis dysfunction. However, knowledge of the intrinsic effects of ageing on cellular calcium ...
  • Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations 

    Riveras Torres, Jose; Calvo, Conrado J.; Llach, Anna; Gúzman Martínez, Gabriela; Caballero, Ricardo; González Gómez, Cristina; Jiménez Borreguero, Luís J.; Guadix, Juan A.; Osorio, Fernando G.; López Otín, Carlos; Herraiz Martínez, Adela; Cabello, Nuria; Vallmitjana Lees, Alex; Benítez Iglesias, Raúl; Gordon, Leslie B. (2016-11-15)
    Article
    Open Access
    Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disease caused by defective prelamin A processing, leading to nuclear lamina alterations, severe cardiovascular pathology, and premature death. Prelamin A ...
  • Distribution and function of cardiac ryanodine receptor clusters in live ventricular myocytes 

    Hiess, Florian; Vallmitjana Lees, Alex; Wang, Ruiwu; Cheng, Hongqiang; ter Keurs, Henk; Chen, Ju; Hove Madsen, Leif; Benítez Iglesias, Raúl; Chen, S. R. Wayne (2015-08-14)
    Article
    Open Access
    The cardiac Ca2+ release channel (ryanodine receptor, RyR2) plays an essential role in excitation-contraction coupling in cardiac muscle cells. Effective and stable excitation-contraction coupling critically depends not ...
  • Identification of intracellular calcium dynamics in stimulated cardiomyocytes 

    Vallmitjana Lees, Alex; Barriga, Montserrat; Nenadic, Zoran; Llach, Anna; Álvarez Lacalle, Enrique; Hove-Madsen, Leif; Benítez Iglesias, Raúl (IEEE Press. Institute of Electrical and Electronics Engineers, 2010)
    Conference report
    Open Access
    We have developed an automatic method for the analysis and identification of dynamical regimes in intracellular calcium patterns from confocal calcium images. The method allows the identification of different dynamical ...
  • Low density lipoproteins promote unstable calcium handling accompanied by reduced SERCA2 and connexin-40 expression in cardiomyocytes 

    Barriga, Montserrat; Cal, Roi; Cabello, Nuria; Llach, Anna; Vallmitjana Lees, Alex; Benítez Iglesias, Raúl; Badimón, Lina; Cinca, J.; Llorente-Cortés, Vicenta; Hove-Madsen, Leif (2013-03-13)
    Article
    Open Access
    The damaging effects of high plasma levels of cholesterol in the cardiovascular system are widely known, but little attention has been paid to direct effects on cardiomyocyte function. We therefore aimed at testing the ...
  • Multilevel analysis of calcium dynamics in stimulated cultures of cardiomyocytes 

    Vallmitjana Lees, Alex; Hove-Madsen, Leif; Barriga, Montserrat; Benítez Iglesias, Raúl (Institute of Electrical and Electronics Engineers (IEEE), 2013)
    Conference report
    Restricted access - publisher's policy
    We present an automatic method to characterize calcium activity in a culture of cardiac cells from a sequence of microscopy fluorescence images. The approach quantifies both the response of each individual cell in the ...
  • Phospholamban knockout breaks arrhythmogenic Ca2+ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice 

    Bai, Yunlong; Jones, Peter; Guo, Jiqing; Zhong, Xiaowei; Clark, Robert; Zhou, Qiang; Wang, Ruiwu; Vallmitjana Lees, Alex; Benítez Iglesias, Raúl; Hove-Madsen, Leif; Semeniuk, Lisa; Guo, Ang; Song, Long-Sheng; Duff, Henry J.; Chen, S.R. Wayne (2013-07-15)
    Article
    Restricted access - publisher's policy
    Rationale: Phospholamban (PLN) is an inhibitor of cardiac sarco(endo)plasmic reticulum Ca2+ ATPase. PLN knockout (PLN-KO) enhances sarcoplasmic reticulum Ca2+ load and Ca2+ leak. Conversely, PLN-KO accelerates Ca2+ ...
  • Prevention of adenosine A2A receptor activation diminishes beat-to-beat alternation in human atrial myocytes 

    Llacher Alsina, Anna Pilar; Vallmitjana Lees, Alex; Benítez Iglesias, Raúl; Montiel Dacosta, José Antonio; Cinca Cusculluela, Juan (2016-01-01)
    Article
    Open Access
    © 2015, Springer-Verlag Berlin Heidelberg. Atrial fibrillation (AF) has been associated with increased spontaneous calcium release from the sarcoplasmic reticulum and linked to increased adenosine A2A receptor (A2AR) ...