Exploració per autor "Molins Lleonart, Eduard"
Ara es mostren els items 1-6 de 6
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An iterative method to protect the type I error rate in bioequivalence studies under two-stage adaptive 2×2 crossover designs
Molins Lleonart, Eduard; Labes, Detlew; Schütz, Helmut; Cobo Valeri, Erik; Ocaña Rebull, Jordi (2021-01)
Article
Accés obertBioequivalence studies are the pivotal clinical trials submitted to regulatory agen- cies to support the marketing applications of generic drug products. Average bioequivalence (ABE) is used to determine whether the mean ... -
Estudios epidemiológicos de Casos-Controles y Cohortes
Molins Lleonart, Eduard; Ocaña Rebull, Jordi; Alarcón Soto, Yovaninna; Robledo, Cefe (2020-11-13)
Audiovisual
Accés obertRepaso de los diferentes diseños de estudios epidemiológicos que existen, centrándose en los estudios prospectivos de cohortes y en los estudios retrospectivos de casos y controles. Se presentan las medidas más habituales ... -
Long-term costs of colorectal cancer treatment in Spain
Corral, julieta; Castells, Xavier; Molins Lleonart, Eduard; Chiarello, Pietro; Borras Andres, Jose Maria; Cots, Francesc (2016-02-16)
Article
Accés obertBackground: Assessing the long-term cost of colorectal cancer (CRC) increases our understanding of the disease burden. The aim of this paper is to estimate the long-term costs of CRC care by stage at diagnosis and phase ... -
Precisió i variabilitat en la interpretació de la mamografia de cribatge : VILMA
Molins Lleonart, Eduard; Moreno Mallén, María Pilar (Universitat Politècnica de Catalunya, 2005-11)
Projecte/Treball Final de Carrera
Accés obertA Catalunya ens trobem en ple procés d'implantació de programes poblacionals de cribratge de càncer de mama, procés que comporta -i comportarà-una necessitat més gran de radiòlegs per a la lectura i interpretació de les ... -
Proposing some innovative study design features to regulatory agencies (EMA and FDA) in bioequivalence trials : Reference Scaled Average Bioequivalence, and Two-Stage Adaptive Designs
Molins Lleonart, Eduard (Universitat Politècnica de Catalunya, 2021-05-28)
Tesi
Accés obertIn applications for generic medicinal products the concept of bioequivalence is fundamental. Two medicinal products, i.e. a test and a reference drugs containing the same active substance are considered bioequivalent if ... -
Two-stage designs versus European scaled average designs in bioequivalence studies for highly variable drugs: which to choose?
Molins Lleonart, Eduard; Cobo Valeri, Erik; Ocaña Rebull, Jordi (2017-12)
Article
Accés obertThe usual approach to determine bioequivalence for highly variable drugs is scaled average bioequivalence, which is based on expanding the limits as a function of the within-subject variability in the reference formulation. ...