• Coiled-coil conformation of a pentamidine-DNA complex 

    Moreno Chicano, Tadeo; Pous, Joan; Subirana Torrent, Juan A.; Campos López, Josefina de Lourdes (2010-03)
    Article
    Accés restringit per política de l'editorial
    The coiled-coil structure formed by the complex of the DNA duplex d(ATATATATAT)2 with pentamidine is presented. The duplex was found to have a mixed structure containing Watson-Crick and Hoogsteen base pairs. The drug ...
  • Crystal structure of a complex of DNA with one AT-hook of HMGA1 

    Fonfria Subirós, Elsa; Acosta Reyes, Francisco Javier; Saperas Plana, Núria; Pous, Joan; Subirana Torrent, Juan A.; Campos López, Josefina de Lourdes (2012-05-16)
    Article
    Accés obert
    We present here for the first time the crystal structure of an AT-hook domain. We show the structure of an AT-hook of the ubiquitous nuclear protein HMGA1, combined with the oligonucleotide d(CGAATTAATTCG)2, which has two ...
  • DNA coiled coil superstructures in oligonucleotide crystals 

    Luchi, Daniela de; Urpí Garriga, Lourdes; Subirana Torrent, Juan A.; Campos López, Josefina de Lourdes (American Chemical Society (ACS), 2011-05-04)
    Article
    Accés restringit per política de l'editorial
    We present the structure of coiled coils found in two oligonucleotide DNA crystals. The sequences d-(ATATATATAT) and d(CGATATATAT) are used. In the first case several coiled coils with different structures are found. In ...
  • Effect of solvent choice on the self-assembly properties of a diphenylalanine amphiphile stabilized by an ion pair 

    Mayans Tayadella, Enric; Ballano Ballano, María Gema; Sendros, Javier; Font Bardia, Mercè; Campos López, Josefina de Lourdes; Puiggalí Bellalta, Jordi; Cativiela, Carlos; Alemán Llansó, Carlos (2017-07-19)
    Article
    Accés restringit per política de l'editorial
    A diphenylalanine (FF) amphiphile blocked at the C terminus with a benzyl ester (OBzl) and stabilized at the N terminus with a trifluoroacetate (TFA) anion was synthetized and characterized. Aggregation of peptide molecules ...
  • Functional and structural analysis of AT-specific minor groove binders that disrupt DNA-protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast 

    Millán Elías, Cinthia Raquel; Acosta Reyes, Francisco Javier; Lagartera, Laura; Ebiloma, Godwin U.; Lemgruber, Leandro; Nué Martinez, J. Jonathan; Saperas Plana, Núria; Dardonville, Cristophe; De Koning, Harry Pieter; Campos López, Josefina de Lourdes (2017-08-21)
    Article
    Accés obert
    Trypanosoma brucei, the causative agent of sleeping sickness (Human African Trypanosomiasis, HAT), contains a kinetoplast with the mitochondrial DNA (kDNA), comprising of >70% AT base pairs. This has prompted studies of ...
  • In and out of the minor groove: Interaction of an AT-rich DNA with the drug CD27 

    Acosta Reyes, Francisco Javier; Dardonville, Cristophe Y.; De Koning, Harry Pieter; Natto, Manal J.; Subirana, Juan Antonio; Campos López, Josefina de Lourdes (2014-06)
    Article
    Accés obert
    The DNA of several pathogens is very rich in AT base pairs. Typical examples include the malaria parasite Plasmodium falciparum and the causative agents of trichomoniasis and trypanosomiases. This fact has prompted studies ...
  • Journal of Materials Chemistry C 

    El-Hachemi, Zoubir; Escudero, Carlos; Acosta-Reyes, Francisco; Casas Becerra, María Teresa; Aloni, Shaul; Oncins, Gerard; Sorrenti, Alessandro; Crusats, Joaquim; Ribó Trujillo, Josep M.; Campos López, Josefina de Lourdes (Royal Society of Chemistry, 2013-03-28)
    Article
    Accés obert
    The structure of the meso-tetrakis(4-sulfonatophenyl)porphyrin (TPPS4) J-aggregates could be determined by X-ray and electron diffraction methods. A sheet-like architecture reveals the relationship between structure and ...
  • Structure of the DNA duplex d(ATTAAT)(2) with Hoogsteen hydrogen bonds 

    Acosta Reyes, Francisco Javier; Subirana, Juan Antonio; Campos López, Josefina de Lourdes; Alechaga, Elida (2015-03-17)
    Article
    Accés obert
    The traditional Watson-Crick base pairs in DNA may occasionally adopt a Hoogsteen conformation, with a different organization of hydrogen bonds. Previous crystal structures have shown that the Hoogsteen conformation is ...
  • Two high-mobility group box domains act together to underwind and kink DNA. 

    Sánchez Giraldo, Raquel; Acosta Reyes, Francisco Javier; Malarkey, Christopher S.; Saperas Plana, Núria; Churchill, Mair E. A.; Campos López, Josefina de Lourdes (2015-07-02)
    Article
    Accés obert
    High-mobility group protein 1 (HMGB1) is an essential and ubiquitous DNA architectural factor that influences a myriad of cellular processes. HMGB1 contains two DNA-binding domains, box A and box B, which have little ...