Now showing items 1-10 of 10

  • Block and graft copolymers made of 16-membered macrolactones and l-Alanine: a comparative study 

    Tinajero, Ernesto; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon; Muñoz Guerra, Sebastián (2019-08-01)
    Article
    Restricted access - publisher's policy
    Block and graft poly(macrolactone)-poly(a-amino acid) copolymers made of l-alanine and pentadecalactone or globalide respectively, are prepared. A sequential ring-opening polymerization (ROP) copolymerization route consisting ...
  • Copolymacrolactones grafted with L-glutamic acid: Synthesis, structure, and nanocarrier properties 

    Tinajero, Ernesto; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon; Muñoz Guerra, Sebastián (Multidisciplinary Digital Publishing Institute (MDPI), 2020-04-24)
    Article
    Open Access
    The enzymatic ring-opening copolymerization (eROP) of globalide (Gl) and pentadecalactone (PDL) was performed in solution from mixtures of the two macrolactones at ratios covering the whole range of comonomeric compositions. ...
  • Hybrid block and graft copolymers made from macrolactones and α-amino acids for applications as drug delivery nanosystems 

    Tinajero, Ernesto (Universitat Politècnica de Catalunya, 2019-07-17)
    Doctoral thesis
    Open Access
    Naturally produced peptides or proteins can be regarded as highly refined polymers. When synthetic polymers are married to proteins or peptides, the resulting bioconjugates can synergistically combine the properties of the ...
  • Metal-free catalyzed ring-opening polymerization and block copolymerization of ¿-pentadecalactone using amino-ended initiators 

    Tinajero, Ernesto; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon; Muñoz Guerra, Sebastián; de Paz, Maria Viola; Galbis Fuster, Elsa (Elsevier, 2018-11-01)
    Article
    Open Access
    Metal-free catalysis was successfully applied to polymerize ¿-pentadecalactone (PDL) by ring-opening polymerization (ROP) using several amino-ended initiators, namely hexylamine, allylamine and O,O'-bis(3-aminopropyl)diethylene ...
  • pH-responsive diblock copolymers made of omega-pentadecalactone and ionically charged alpha-amino acids 

    Tinajero, Ernesto; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon; Muñoz Guerra, Sebastián (Elsevier, 2019-11-01)
    Article
    Restricted access - publisher's policy
    Two sets of ionically charged polypentadecalactone-polypeptide diblock copolymers (PPDLx-b-PAAy, with x= 15 or 20 and y ranging from 30 to 200), one containing alpha-L-glutamic acid (LGA) and the other containing ...
  • Poly(amino acid)-grafted polymacrolactones. Synthesis, self-assembling and ionic coupling properties 

    Tinajero, Ernesto; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon; Cavanagh, Breton; Heise, Andreas; Muñoz Guerra, Sebastián (2019-01-01)
    Article
    Restricted access - publisher's policy
    Polyglobalide (PGl) with number average polymerization degree of ~20 was prepared by enzymatic ROP and then polyfunctionalized at 60% with aminothioethylene groups. The PGl20-(NH2)12 copolymer was used as macroinitiator ...
  • Poly(ether-ester-peptide) triblock copolymers: Synthesis and self-assembly behavior 

    Tinajero, Ernesto; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon; Muñoz Guerra, Sebastián (Universidad de Burgos. Servicio de publicaciones e imagen institucional, 2019)
    Conference lecture
    Restricted access - publisher's policy
    Triblock/grafted poly(ether-ester-peptide) copolymers made or PEG, poly(globablide) and poly(L-phenylalanine) were synthesized by sequential ROP starting from diaminated PEG as first initiator. The aromatic functionality ...
  • Ring opening polymerization of macrolactones using amines as initiators 

    Tinajero, Ernesto; Lavilla, Cristina; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon; Muñoz Guerra, Sebastián (2016)
    Conference lecture
    Open Access
    The ring opening polymerization (ROP) of these macrolactones mediated by alcohols as initiators and organic and metal-based catalysts has been reported before with satisfactory results [4,5]. In the present work, the ...
  • Synthesis and properties of diblock copolymers of omega-pentadecalactone and alpha-amino acids 

    Tinajero, Ernesto; Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon; Muñoz Guerra, Sebastián (Elsevier, 2019-07-01)
    Article
    Restricted access - publisher's policy
    Diblock copolymers (PPDLx-b-pPAAy) were prepared from ¿-pentadecalactone and l-glutamic acid or l-lysine amino acids by ring opening polymerization initiated by amino groups. Telechelic amino-ended poly(¿-pentadecalactone) ...
  • Validation of smart nanoparticles as controlled drug delivery systems: loading and pH-dependent release of pilocarpine 

    Galbis Fuster, Elsa; Iglesias González, Nieves; Lucas Rodríguez, Ricardo; Tinajero, Ernesto; Muñoz Guerra, Sebastián (American Chemical Society (ACS), 2017-09-25)
    Article
    Open Access
    Micelles are good devices for use as controlled drug delivery systems because they exhibit the ability to protect the encapsulated substance from the routes of degradation until they reach the site of action. The present ...