Now showing items 1-13 of 13

    • Cold atmospheric plasma enhances doxorubicin selectivity in metastasic bone cancer 

      Mateu Sanz, Miguel; Ginebra Molins, Maria Pau; Tornin Cavielles, Juan; Canal Barnils, Cristina (2022-08)
      Article
      Open Access
      High-dose systemic chemotherapy constitutes a main strategy in the management of bone metastases, employing drugs like doxorubicin (DOX), related with severe side effects. To solve this issue, Cold Atmospheric Plasmas (CAP) ...
    • Cold atmospheric plasma: a new strategy based primarily on oxidative stress for osteosarcoma therapy 

      Mateu Sanz, Miguel; Tornin Cavielles, Juan; Ginebra Molins, Maria Pau; Canal Barnils, Cristina (Multidisciplinary Digital Publishing Institute (MDPI), 2021-02-23)
      Article
      Open Access
      Osteosarcoma is the most common primary bone tumor, and its first line of treatment presents a high failure rate. The 5-year survival for children and teenagers with osteosarcoma is 70% (if diagnosed before it has metastasized) ...
    • Cold plasma and inhibition of STAT3 selectively target tumorigenicity in osteosarcoma 

      Tornin Cavielles, Juan; Mateu Sanz, Miguel; Rey, Veronica; Murillo, Dzohara; Huergo García, Carmen; Gallego, Borja; Rodríguez, Aida; Rodríguez, René; Canal Barnils, Cristina (2023-06-01)
      Article
      Open Access
      Covenantee:   Institut de Recerca Sant Joan de Déu / Hospital Universitario Central de Asturias / Instituto Universitario de Oncología del Principado de Asturias / CIBERONC. Centro de Investigación Biomédica en Red. Cáncer
      Osteosarcoma (OS) is a malignant type of bone cancer that arises in periods of increased bone formation. Curative strategies for these types of tumors have remained essentially unchanged for decades and the overall survival ...
    • Evaluation of the effects of cold atmospheric plasma and plasma-treated liquids in cancer cell cultures [Dataset] 

      Tornin Cavielles, Juan; Labay, Cédric Pierre; Tampieri, Francesco; Ginebra Molins, Maria Pau; Canal Barnils, Cristina (Universitat Politècnica de Catalunya, 2020)
      Dataset
      Open Access
      The present dataset corresponds to the anticipated results that can be obtained following the protocol described in the article. In particular, dataset corresponding to Figure 8 presents the absorbance values from the WST-1 ...
    • Evaluation on the effects of cold atmospheric plasma and plasma-treated liquids in cancer cell cultures 

      Tornin Cavielles, Juan; Labay, Cédric Pierre; Tampieri, Francesco; Ginebra Molins, Maria Pau; Canal Barnils, Cristina (2021-06-21)
      Article
      Open Access
      Covenantee:   Instituto de Investigación Sanitaria del Principado de Asturias / Institut de Bioenginyeria de Catalunya
      Cold atmospheric plasma (CAP) is a potential anticancer therapy. CAP has cytotoxic effects when applied either directly to cancer cell cultures or indirectly through plasma-conditioned liquids. This protocol describes how ...
    • FUS-CHOP promotes invasion in myxoid liposarcoma through a SRC/FAK/RHO/ROCK-dependent pathway 

      Tornin Cavielles, Juan; Hermida Prado, Francisco; Singh Singh, Ranjit; González, M. Victoria (2017-01-28)
      Article
      Open Access
      Deregulated SRC/FAK signaling leads to enhanced migration and invasion in many types of tumors. In myxoid and round cell liposarcoma (MRCLS), an adipocytic tumor characterized by the expression of the fusion oncogene ...
    • Influence of the composition of plasma-activated medium on osteosarcoma 

      Canal Barnils, Cristina; Tornin Cavielles, Juan; Mateu, Miguel; Hamouda, Inés; Labay, Cédric Pierre; Guillem Martí, Jordi; Ginebra Molins, Maria Pau (2018)
      Conference report
      Open Access
    • Mithramycin delivery systems to develop effective therapies in sarcomas 

      Estupiñan, Oscar; Rey Vázquez, Verónica; Tornin Cavielles, Juan; Moris, Francisco; González Meana, M. Victoria (Springer Nature, 2021-12)
      Article
      Open Access
      Covenantee:   Instituto de Investigación Sanitaria del Principado de Asturias
      Sarcomas comprise a group of aggressive malignancies with very little treatment options beyond standard chemotherapy. Reposition of approved drugs represents an attractive approach to identify effective therapeutic compounds. ...
    • Osteosarcoma tissue-engineered model challenges oxidative stress therapy revealing promoted cancer stem cell properties 

      Tornin Cavielles, Juan; Villasante Bermejo, Aránzazu; Solé Martí, Xavier; Ginebra Molins, Maria Pau; Canal Barnils, Cristina (2021-02)
      Article
      Open Access
      Covenantee:   Instituto de Investigación Sanitaria del Principado de Asturias
      The use of oxidative stress generated by Cold Atmospheric Plasma (CAP) in oncology is being recently studied as a novel potential anti-cancer therapy. However, the beneficial effects of CAP for treating osteosarcoma have ...
    • Osteosarcoma tissue-engineered model challenges oxidative stress therapy revealing promoted cancer stem cell properties [Dataset] 

      Tornin Cavielles, Juan; Villasante, Aranzazu; Sole Marti, Xavi; Ginebra Molins, Maria Pau; Canal Barnils, Cristina (Universitat Politècnica de Catalunya, 2020)
      Dataset
      Restricted access - author's decision
      The use of Cold Atmospheric Plasma (CAP) in oncology is being recently studied as a novel potential anti-cancer therapy. However, the beneficial effects of CAP for treating osteosarcoma have mostly been demonstrated in ...
    • Pyruvate plays a main role in the antitumoral selectivity of cold atmospheric plasma in osteosarcoma 

      Tornin Cavielles, Juan; Mateu Sanz, Miguel; Rodríguez, Aida; Labay, Cédric Pierre; Rodríguez, Rene; Canal Barnils, Cristina (Nature, 2019-07-23)
      Article
      Open Access
      Covenantee:   Hospital Universitario Central de Asturias / Instituto Universitario de Oncología del Principado de Asturias / Centro de Investigación Biomédica en Red. Bioingeniería, Biomateriales y Nanomedicina
      Osteosarcoma (os) is the most common primary bone tumor but current therapies still have poor prognosis. Cold Atmospheric Plasma (CAP) and Plasma activated media (PAM) have shown potential to eliminate cancer cells in other ...
    • Selectively targeting tumorigenicity in osteosarcoma 

      Tornin Cavielles, Juan; Mateu Sanz, Miguel; Rey, Verónica; Murillo, Dzohara; Huergo, Carmen; Rodríguez, Aida; Rodríguez, René; Canal Barnils, Cristina (Universitat Politècnica de Catalunya, 2022-03-14)
      Dataset
      Open Access
    • The multikinase inhibitor EC‐70124 synergistically increased the antitumor activity of doxorubicin in sarcomas 

      Estupiñan, Oscar; Santos, Laura; Rodriguez, Aida; Fernandez-Nevado, Lucia; Costales, Paula; Perez‐Escuredo, Jhudit; Hermosilla, Maria Ana; Oro, Patricia; Rey, Veronica; Tornin Cavielles, Juan; Allonca, Eva; Fernandez Garcia, Maria Teresa; Alvarez Fernandez, Carlos; Braña, Alejandro; Astudillo, Aurora; Menendez, Sofia T.; Moris, Francisco; Rodriguez, Rene (Wiley (John Wiley & Sons), 2018-12-21)
      Article
      Open Access
      Cytotoxic drugs like doxorubicin remain as the most utilized agents in sarcoma treatment. However, advanced sarcomas are often resistant, thus stressing the need for new therapies aimed to overcome this resistance. Multikinase ...