Browsing by Author "Romanini, Michela"
Now showing items 1-20 of 44
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Amorphous binary dispersions of chloramphenicol in enantiomeric pure and racemic poly-lactic acid: morphology, molecular relaxations, and controlled drug release
Valenti, Sofia; Díaz Andrade, Angélica María; Romanini, Michela; Valle Mendoza, Luis Javier del; Puiggalí Bellalta, Jordi; Tamarit Mur, José Luis; Macovez, Roberto (2019-09-10)
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Open AccessWe study amorphous solid dispersions (ASDs) of the chloramphenicol antibiotic in two biodegradable polylactic acid polymers, namely a commercial sample of enantiomeric pure PLLA and a home-synthesized PDLLA copolymer, to ... -
C60 solvate with (1,1,2)-trichloroethane: dynamic statistical disorder and mixed conformation
Mitsari, Efstratia; Romanini, Michela; Qureshi, Navid; Tamarit Mur, José Luis; Barrio Casado, María del; Macovez, Roberto (2016-05-27)
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Open AccessWe present a full characterization of the orientationally disordered cocrystal of C-60 with (1,1,2)-triChloroethane (C2H3Cl3), by means of X-ray diffraction, Raman spectroscopy, and broadband dielectric spectroscopy. Our ... -
Collective relaxation dynamics and crystallization kinetics of the amorphous Biclotymol antiseptic
Tripathi, Pragya; Romanini, Michela; Tamarit Mur, José Luis; Macovez, Roberto (2015-11-10)
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Open AccessWe employ dielectric spectroscopy to monitor the relaxation dynamics and crystallization kinetics of the Biclotymol antiseptic in its amorphous phase. The glass transition temperature of the material as determined by ... -
Comparative physical study of three pharmaceutically active benzodiazepine derivatives: crystalline versus amorphous state and crystallization tendency
Valenti, Sofia; Barrio Casado, María del; Negrier, Philippe; Romanini, Michela; Macovez, Roberto; Tamarit Mur, José Luis (American Chemical Society, 2021-01-01)
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Open AccessChemical derivatization and amorphization are two possible strategies to improve the solubility and bioavailability of drugs, which is a key issue for the pharmaceutical industry. In this contribution, we explore whether ... -
Double primary relaxation in a highly anisotropic orientational glass-former with low-dimensional disorder
Romanini, Michela; Barrio Casado, María del; Capaccioli, Simon; Ruíz Martín, María Dolores; Macovez, Roberto; Tamarit Mur, José Luis (2016-04-26)
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Open AccessThe freezing of the cooperative reorientational motions in orientationally disordered (OD) molecular crystals marks the so-called \glassy" transition, which may be considered a lower-dimensional version of the structural ... -
Drug-biopolymer dispersions: morphology-and temperature-dependent (anti)plasticizer effect of the drug and component-specific Johari–Goldstein relaxations
Valenti, Sofia; Valle Mendoza, Luis Javier del; Romanini, Michela; Mitjana Rusiñol, Meritxell; Puiggalí Bellalta, Jordi; Tamarit Mur, José Luis; Macovez, Roberto (2022-03-01)
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Open AccessAmorphous molecule-macromolecule mixtures are ubiquitous in polymer technology and are one of the most studied routes for the development of amorphous drug formulations. For these applications it is crucial to understand ... -
Emergence of glassy-like dynamics in an orientationally ordered phase
Romanini, Michela; Negrier, Philippe; Tamarit Mur, José Luis; Capaccioli, Simon; Barrio Casado, María del; Pardo Soto, Luis Carlos; Mondieig, Denise (2012-04-04)
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Open AccessThe dynamics of a simple rigid pseudoglobular molecule (2-adamantanone) has been studied by means of dielectric spectroscopy and examined under the constraints imposed by the space group of the crystal structure determined ... -
Enhancement of the physical and chemical stability of amorphous drug-polymer mixtures via cryogenic comilling
Romanini, Michela; Lorente, Marta; Schammé, Benjamin; Delbreilh, Laurent; Dupray, Valérie; Coquerel, Gerard; Tamarit Mur, José Luis; Macovez, Roberto (American Chemical Society (ACS), 2018-11-27)
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Open AccessAmorphous dispersions of the Biclotymol antiseptic are obtained in polyvinylpyrrolidone (PVP), for different drug loadings, by comilling at temperatures below the glass transition of both components. Characterization of ... -
Eutectic mixture formation and relaxation dynamics of coamorphous mixtures of two benzodiazepine drugs
Valenti, Sofia; Cazorla Silva, Claudio; Romanini, Michela; Tamarit Mur, José Luis; Macovez, Roberto (Multidisciplinary Digital Publishing Institute (MDPI), 2023-01-01)
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Open AccessThe formation of coamorphous mixtures of pharmaceuticals is an interesting strategy to improve the solubility and bioavailability of drugs, while at the same time enhancing the kinetic stability of the resulting binary ... -
Genuine antiplasticizing effect of water on a glass-former drug
Ruiz Tabbia, Guadalupe Natalia; Romanini, Michela; Hauptmann, Astrid; Loerting, Thomas; Shalaev, Evgenyi; Tamarit Mur, José Luis; Pardo Soto, Luis Carlos; Macovez, Roberto (Macmillan Publishers, 2017-08-07)
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Open AccessWater is the most important plasticizer of biological and organic hydrophilic materials, which generally exhibit enhanced mechanical softness and molecular mobility upon hydration. The enhancement of the molecular dynamics ... -
Giant and reversible barocaloric effect in trinuclear spin-crossover complex Fe3(bntrz)6(tcnset)6
Romanini, Michela; Lloveras Muntané, Pol Marcel; Barrio Casado, María del; Aznar Luque, Araceli; Gracia Condal, Adrià; Emre, Baris; Tamarit Mur, José Luis; Planes Vila, Antoni; Manosa, L (2021-03)
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Open AccessA giant barocaloric effect (BCE) in a molecular material Fe3(bntrz)6(tcnset)6 (FBT) is reported, where bntrz = 4-(benzyl)-1,2,4-triazole and tcnset = 1,1,3,3-tetracyano-2-thioethylepropenide. The crystal structure of FBT ... -
Giant barocaloric effects over a wide temperature range in the superionic conductor AgI
Aznar Luque, Araceli; LLoveras, Pol; Romanini, Michela; Barrio Casado, María del; Tamarit Mur, José Luis; Cazorla Silva, Claudio; Errandonea Ponce, Daniel; Mathur, N.D.; Planes, Antoni; Moya, Xavier; Mañosa Carrera, Lluis (2017-11-29)
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Open AccessCurrent interest in barocaloric effects has been stimulated by the discovery that these pressure-driven thermal changes can be giant near ferroic phase transitions in materials that display magnetic or electrical order. ... -
Glass transition, crystallization kinetics, and inter-conformer relaxation dynamics of amorphous mitotane and related compounds
Romanini, Michela; Pérez Valmaseda, Alex; Macovez, Roberto (Elsevier, 2022-12-15)
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Open AccessWe employ differential scanning calorimetry, broadband dielectric spectroscopy and optical microscopy to investigate the glass transition, molecular relaxation dynamics, and isothermal recrystallization kinetics of amorphous ... -
Heat sink avalanche dynamics in elastocaloric Cu-Al-Ni single crystal detected by infrared calorimetry and Gaussian filtering
Capellera, Guillem; Lanniciello, Lucia; Romanini, Michela; Vives Santa-Eulàlia, Eduard (2021-10-11)
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Open AccessThe physics behind the cooling process occurring in an elastocaloric Cu–Al–Ni wire during the martensite to austenite transition after stress release is studied. A previous experiment using infrared imaging determined the ... -
Hopping conductivity and polarization effects in a fullerene derivative salt
Macovez, Roberto; Zachariah, Manesh; Romanini, Michela; Zygouri, Panagiota; Gournis, Dimitrios; Tamarit Mur, José Luis (2014-06-12)
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Restricted access - publisher's policyImpedance spectroscopy is employed to probe the frequency-dependent conductivity and dielectric response of the C60O24Na 24 fulleride. The conduction properties of this organic material match the so-called universal behavior ... -
Implanted muon spin spectroscopy on 2-O-adamantane: a model system that mimics the liquid
Romanini, Michela; Tamarit Mur, José Luis; Pardo Soto, Luis Carlos; Bermejo, F. J.; Fernandez Perea, Ricardo; Pratt, F. L. (2017-03-01)
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Open AccessThe transition taking place between two metastable phases in 2-O-adamantane, namely the [Formula: see text] cubic, rotator phase and the lower temperature P21/c, Z = 4 substitutionally disordered crystal is studied by ... -
Inter-enantiomer conversion dynamics and Johari–Goldstein relaxation of benzophenones
Romanini, Michela; Macovez, Roberto; Tamarit Mur, José Luis (Nature, 2021-10-12)
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Open AccessWe employ temperature- and pressure-dependent dielectric spectroscopy, as well as differential scanning calorimetry, to characterize benzophenone and the singly-substituted ortho-bromobenzophenone derivative in the liquid ... -
Large barocaloric effects in two novel ferroelectric molecular plastic crystals
Salvatori, Alejandro; Aguilà Aviles, David; Aromí, Guillem; Mañosa Carrera, Lluis; Planes Vila, Antoni; Lloveras Muntané, Pol Marcel; Pardo Soto, Luis Carlos; Appel, Markus; Nataf, Guillaume F.; Giovannelli, Fabien; Barrio Casado, María del; Tamarit Mur, José Luis; Romanini, Michela (Royal Society of Chemistry (RSC), 2023-05-19)
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Restricted access - publisher's policyMaterials undergoing pressure-driven solid–solid phase transformations can be a valuable alternative for eco-friendly refrigeration, heat pumping and waste heat recovery based on the barocaloric effect. Ferroelectric ... -
Mixtures of m-fluoroaniline with apolar aromatic molecules: Phase behaviour, suppression of H-bonded clusters, and local H-bond relaxation dynamics
Romanini, Michela; Barrio Casado, María del; Macovez, Roberto; Capaccioli, Simon; Tamarit Mur, José Luis (2019-12-15)
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Open AccessWe employ differential scanning calorimetry, IR spectroscopy, X-ray powder diffraction and dielectric spectroscopy to characterize binary mixtures of m-fluoroaniline (mFA), a rigid-molecule glass former, with two ... -
Molecular diffusion and dc conductivity perfectly correlated with molecular rotational dynamics in a plastic crystalline electrolyte
Zachariah, Manesh; Romanini, Michela; Tripathi, Pragya; Tamarit Mur, José Luis; Macovez, Roberto (2015-01-01)
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Open Access