Browsing by Author "Romanini, Michela"
Now showing items 1-20 of 44
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Amorphous binary dispersions of chloramphenicol in enantiomeric pure and racemic poly-lactic acid: morphology, molecular relaxations, and controlled drug release
(2019-09-10)
Article
Open AccessWe study amorphous solid dispersions (ASDs) of the chloramphenicol antibiotic in two biodegradable polylactic acid polymers, namely a commercial sample of enantiomeric pure PLLA and a home-synthesized PDLLA copolymer, to ... -
C60 solvate with (1,1,2)-trichloroethane: dynamic statistical disorder and mixed conformation
(2016-05-27)
Article
Open AccessWe present a full characterization of the orientationally disordered cocrystal of C-60 with (1,1,2)-triChloroethane (C2H3Cl3), by means of X-ray diffraction, Raman spectroscopy, and broadband dielectric spectroscopy. Our ... -
Collective relaxation dynamics and crystallization kinetics of the amorphous Biclotymol antiseptic
(2015-11-10)
Article
Open AccessWe employ dielectric spectroscopy to monitor the relaxation dynamics and crystallization kinetics of the Biclotymol antiseptic in its amorphous phase. The glass transition temperature of the material as determined by ... -
Comparative physical study of three pharmaceutically active benzodiazepine derivatives: crystalline versus amorphous state and crystallization tendency
(American Chemical Society, 2021-01-01)
Article
Open AccessChemical derivatization and amorphization are two possible strategies to improve the solubility and bioavailability of drugs, which is a key issue for the pharmaceutical industry. In this contribution, we explore whether ... -
Double primary relaxation in a highly anisotropic orientational glass-former with low-dimensional disorder
(2016-04-26)
Article
Open AccessThe freezing of the cooperative reorientational motions in orientationally disordered (OD) molecular crystals marks the so-called \glassy" transition, which may be considered a lower-dimensional version of the structural ... -
Drug-biopolymer dispersions: morphology-and temperature-dependent (anti)plasticizer effect of the drug and component-specific Johari–Goldstein relaxations
(2022-03-01)
Article
Open AccessAmorphous molecule-macromolecule mixtures are ubiquitous in polymer technology and are one of the most studied routes for the development of amorphous drug formulations. For these applications it is crucial to understand ... -
Emergence of glassy-like dynamics in an orientationally ordered phase
(2012-04-04)
Article
Open AccessThe dynamics of a simple rigid pseudoglobular molecule (2-adamantanone) has been studied by means of dielectric spectroscopy and examined under the constraints imposed by the space group of the crystal structure determined ... -
Enhancement of the physical and chemical stability of amorphous drug-polymer mixtures via cryogenic comilling
(American Chemical Society (ACS), 2018-11-27)
Article
Open AccessAmorphous dispersions of the Biclotymol antiseptic are obtained in polyvinylpyrrolidone (PVP), for different drug loadings, by comilling at temperatures below the glass transition of both components. Characterization of ... -
Eutectic mixture formation and relaxation dynamics of coamorphous mixtures of two benzodiazepine drugs
(Multidisciplinary Digital Publishing Institute (MDPI), 2023-01-01)
Article
Open AccessThe formation of coamorphous mixtures of pharmaceuticals is an interesting strategy to improve the solubility and bioavailability of drugs, while at the same time enhancing the kinetic stability of the resulting binary ... -
Genuine antiplasticizing effect of water on a glass-former drug
(Macmillan Publishers, 2017-08-07)
Article
Open AccessWater is the most important plasticizer of biological and organic hydrophilic materials, which generally exhibit enhanced mechanical softness and molecular mobility upon hydration. The enhancement of the molecular dynamics ... -
Giant and reversible barocaloric effect in trinuclear spin-crossover complex Fe3(bntrz)6(tcnset)6
(2021-03)
Article
Open AccessA giant barocaloric effect (BCE) in a molecular material Fe3(bntrz)6(tcnset)6 (FBT) is reported, where bntrz = 4-(benzyl)-1,2,4-triazole and tcnset = 1,1,3,3-tetracyano-2-thioethylepropenide. The crystal structure of FBT ... -
Giant barocaloric effects over a wide temperature range in the superionic conductor AgI
(2017-11-29)
Article
Open AccessCurrent interest in barocaloric effects has been stimulated by the discovery that these pressure-driven thermal changes can be giant near ferroic phase transitions in materials that display magnetic or electrical order. ... -
Glass transition, crystallization kinetics, and inter-conformer relaxation dynamics of amorphous mitotane and related compounds
(Elsevier, 2022-12-15)
Article
Open AccessWe employ differential scanning calorimetry, broadband dielectric spectroscopy and optical microscopy to investigate the glass transition, molecular relaxation dynamics, and isothermal recrystallization kinetics of amorphous ... -
Heat sink avalanche dynamics in elastocaloric Cu-Al-Ni single crystal detected by infrared calorimetry and Gaussian filtering
(2021-10-11)
Article
Open AccessThe physics behind the cooling process occurring in an elastocaloric Cu–Al–Ni wire during the martensite to austenite transition after stress release is studied. A previous experiment using infrared imaging determined the ... -
Hopping conductivity and polarization effects in a fullerene derivative salt
(2014-06-12)
Article
Restricted access - publisher's policyImpedance spectroscopy is employed to probe the frequency-dependent conductivity and dielectric response of the C60O24Na 24 fulleride. The conduction properties of this organic material match the so-called universal behavior ... -
Implanted muon spin spectroscopy on 2-O-adamantane: a model system that mimics the liquid
(2017-03-01)
Article
Open AccessThe transition taking place between two metastable phases in 2-O-adamantane, namely the [Formula: see text] cubic, rotator phase and the lower temperature P21/c, Z = 4 substitutionally disordered crystal is studied by ... -
Inter-enantiomer conversion dynamics and Johari–Goldstein relaxation of benzophenones
(Nature, 2021-10-12)
Article
Open AccessWe employ temperature- and pressure-dependent dielectric spectroscopy, as well as differential scanning calorimetry, to characterize benzophenone and the singly-substituted ortho-bromobenzophenone derivative in the liquid ... -
Large barocaloric effects in two novel ferroelectric molecular plastic crystals
(Royal Society of Chemistry (RSC), 2023-05-19)
Article
Restricted access - publisher's policyMaterials undergoing pressure-driven solid–solid phase transformations can be a valuable alternative for eco-friendly refrigeration, heat pumping and waste heat recovery based on the barocaloric effect. Ferroelectric ... -
Mixtures of m-fluoroaniline with apolar aromatic molecules: Phase behaviour, suppression of H-bonded clusters, and local H-bond relaxation dynamics
(2019-12-15)
Article
Open AccessWe employ differential scanning calorimetry, IR spectroscopy, X-ray powder diffraction and dielectric spectroscopy to characterize binary mixtures of m-fluoroaniline (mFA), a rigid-molecule glass former, with two ... -
Molecular diffusion and dc conductivity perfectly correlated with molecular rotational dynamics in a plastic crystalline electrolyte
(2015-01-01)
Article
Open Access
