Browsing by Author "Picart Armada, Sergio"
Now showing items 1-13 of 13
-
Amitriptyline at an environmentally relevant concentration alters the profile of metabolites beyond monoamines in gilt-head bream
(2019-01-31)
Article
Open AccessThe antidepressant amitriptyline is a widely used selective serotonin reuptake inhibitor that is found in the aquatic environment. The present work investigates alterations in the brain and liver metabolome of gilt-head ... -
Balancing data on deep learning-based proteochemometric activity classification
(2021-01-01)
Article
Restricted access - publisher's policyIn silico analysis of biological activity data has become an essential technique in pharmaceutical development. Specifically, the so-called proteochemometric models aim to share information between targets in machine ... -
Benchmarking network propagation methods for disease gene identification
(2019-09-01)
Article
Open AccessIn-silico identification of potential target genes for disease is an essential aspect of drug target discovery. Recent studies suggest that successful targets can be found through by leveraging genetic, genomic and protein ... -
Biological Pathway enrichment of Liquid Chromatography - Mass Spectrometry data through spectral graph analysis
(Universitat Politècnica de Catalunya, 2014-07)
Master thesis (pre-Bologna period)
Restricted access - author's decisionEls experiments de recerca biol ogica sobre el metabolisme hum a solen usar CL/EM, Cromatografi a Li quida - Espectrometria de Masses, per obtenir informaci o sobre els compostos a les mostres,per o aquest tipus de dades ... -
diffuStats: an R package to compute diffusion-based scores on biological networks
(2018-02-01)
Article
Open AccessLabel propagation and diffusion over biological networks are a common mathematical formalism in computational biology for giving context to molecular entities and prioritising novel candidates in the area of study. There ... -
Enriquecimiento mediante vías metabólicas de datos de Cromatografía Líquida- Espectrometría de Masas a través de análisis espectral de grafos
(2014)
Conference report
Open AccessUna de las técnicas experimentales más extendidas en el ámbito de investigación biológica y la química analítica es la Cromatografía Líquida – Espectrometría de Masas, CL/EM, cuya salida informa sobre los compuestos presentes ... -
FELLA: an R package to enrich metabolomics data
(2018-12-22)
Article
Open AccessBackground: Pathway enrichment techniques are useful for understanding experimental metabolomics data. Their purpose is to give context to the affected metabolites in terms of the prior knowledge contained in metabolic ... -
MultiPaths: a Python framework for analyzing multi-layer biological networks using diffusion algorithms
(2020-12-26)
Article
Open AccessHigh-throughput screening yields vast amounts of biological data which can be highly challenging to interpret. In response, knowledge-driven approaches emerged as possible solutions to analyze large datasets by leveraging ... -
mWISE: an algorithm for context-based annotation of liquid chromatography–mass spectrometry features through diffusion in graphs
(2021-07-28)
Article
Open AccessUntargeted metabolomics using liquid chromatography coupled to mass spectrometry (LC–MS) allows the detection of thousands of metabolites in biological samples. However, LC–MS data annotation is still considered a major ... -
Non-targeted metabolomics reveals alterations in liver and plasma of gilt-head bream exposed to oxybenzone
(2018-08-04)
Article
Open AccessThe extensive use of the organic UV filter oxybenzone has led to its ubiquitous occurrence in the aquatic environment, causing an ecotoxicological risk to biota. Although some studies reported adverse effects, such as ... -
Null diffusion-based enrichment for metabolomics data
(2017-12-06)
Article
Open AccessMetabolomics experiments identify metabolites whose abundance varies as the conditions under study change. Pathway enrichment tools help in the identification of key metabolic processes and in building a plausible biological ... -
Statistical normalisation of network propagation methods for computational biology
(Universitat Politècnica de Catalunya, 2020-07-23)
Doctoral thesis
Open AccessThe advent of high-throughput technologies and their decreasing cost have fostered the creation of a rich ecosystem of public database resources. In an era of affordable data acquisition, the core challenge has shifted to ... -
The effect of statistical normalisation on network propagation scores
(2020-10-18)
Article
Open AccessNetwork diffusion and label propagation are fundamental tools in computational biology, with applications like gene-disease association, protein function prediction and module discovery. More recently, several publications ...
