Now showing items 1-20 of 21

    • A complementary energy approach accommodates scale differences in soft tissues 

      Sáez Viñas, Pablo; Eppell, Steven J.; Ballarini, Roberto; Rodríguez Matas, José Félix (2020-05-01)
      Article
      Restricted access - publisher's policy
      The mechanics of biological entities, from single molecules to the whole organ, has been extensively analyzed during the last decades. At the smaller scales, statistical mechanics has fostered successful physical models ...
    • A structural approach including the behavior of collagen cross-links to model patient-specific human carotid arteries 

      Sáez Viñas, Pablo; Peña, Estefanía; Martínez, Miguel Angel (2014)
      Article
      Open Access
      The objective of this work is to develop a remodeling model for biological matter coupling two different processes in a 3D framework: reorientation of the preferential direction of a given fibered structure and reorientation ...
    • A theoretical model of the endothelial cell morphology due to different waveforms 

      Sáez Viñas, Pablo; Malve, M.; Martínez, M.A. (2015-08)
      Article
      Open Access
      Endothelial cells are key units in the regulatory biological process of blood vessels. They represent an interface to transmit variations on the fluid dynamic changes. They are able to adapt its cytoskeleton, by means of ...
    • An anisotropic microsphere-based approach for fiber orientation adaptation in soft tissue 

      Sáez Viñas, Pablo; Pena, Estefanía; Doblaré, Manuel; Martínez, Miguel Ángel (2011)
      Article
      Open Access
      Evolutionary processes in biological tissue, such as adaptation or remodeling, represent an enterprising area of research. In this paper, we present a multiscale model for the remodeling of fibered structures, such as ...
    • Anisotropic microsphere-based approach to damage in soft fibered tissue 

      Sáez Viñas, Pablo; Alastrué, V.; Pena, Estefania; Doblaré, Manuel; Martínez, Miguel Ángel (2012-05)
      Article
      Open Access
      An anisotropic damage model for soft fibered tissue is presented in this paper, using a multi-scale scheme and focusing on the directionally dependent behavior of these materials. For this purpose, a micro-structural or, ...
    • Bulging brains 

      Weickenmeie, J.; Sáez Viñas, Pablo; Butler, C. A.; Young, P.G.; Gorily, A.; Kuhl, Ellen (2016-10)
      Article
      Open Access
      Brain swelling is a serious condition associated with an accumulation of fluid inside the brain caused by trauma, stroke, infection, or tumors. It increases the pressure inside the skull and reduces blood and oxygen supply. ...
    • Computational model of collagen turnover in carotid arteries during hypertension 

      Sáez Viñas, Pablo; Peña, Estefanía; Tarbell, J.M.; Martínez, Miguel Angel (John Wiley & Sons, Ltd, 2015-02)
      Article
      Open Access
      t is well known that biological tissues adapt their properties because of different mechanical and chemical stimuli. The goal of this work is to study the collagen turnover in the arterial tissue of hypertensive patients ...
    • Computational modeling of acute myocardial infarction 

      Sáez Viñas, Pablo; Kuhl, E. (Gordon and Breach Science Publishers, 2016-07)
      Article
      Open Access
      Myocardial infarction, commonly known as heart attack, is caused by reduced blood supply and damages the heart muscle because of a lack of oxygen. Myocardial infarction initiates a cascade of biochemical and mechanical ...
    • Computational modeling of epithelial wound healing: Short and long term chemo-mechanical mechanisms 

      Roldan, Lisandro; Muñoz Romero, José; Sáez Viñas, Pablo (2019-06-15)
      Article
      Open Access
      During the lifetime of all living multicellular organisms, wounds in their tissues are frequently observed. Thecapability of closing those gaps is fundamental for a healthy development. If done deficiently, many diseasesmay ...
    • Computational modeling of hypertensive growth in the human carotid artery 

      Sáez Viñas, Pablo; Peña, Estefanía; Martínez, Miguel Ángel; Kuhl, Ellen (2014-06)
      Article
      Open Access
      Arterial hypertension is a chronic medical condition associated with an elevated blood pressure. Chronic arterial hypertension initiates a series of events, which are known to collectively initiate arterial wall thickening. ...
    • Fully coupled numerical model of actin treadmilling in the lamellipodium of the cell 

      Kollepara, Kiran Sagar; Mulye, Paris D.; Sáez Viñas, Pablo (John Wiley & sons, 2018-12)
      Article
      Open Access
      Cells rely on an interplay of subcellular elements for motility and migration. Certain regions of motile cells, such as the lamellipodium, are made of a complex mixture of actin monomers and filaments, which polymerize at ...
    • Hierarchical micro-adaptation of biological structures by mechanical stimuli 

      Sáez Viñas, Pablo; Pena, Estefanía; Doblaré, Manuel; Martínez, Miguel Ángel (2013)
      Article
      Open Access
      Remodeling and other evolving processes such as growth or morphogenesis are key factors in the evolution of biological tissue in response to both external and internal epigenetic stimuli. Based on the description of these ...
    • Mathematical modeling of collagen turnover in biological tissue 

      Sáez Viñas, Pablo; Peña, Estefania; Martínez, Miguel Àngel; Kuhl, Ellen (2012)
      Article
      Open Access
      We present a theoretical and computational model for collagen turnover in soft biological tissues. Driven by alterations in the mechanical environment, collagen fiber bundles may undergo important chronic changes, characterized ...
    • Mechanical and microstructural behavior of vascular tissue 

      Peña Baquedano, Estefania; García González, Alberto; Sáez Viñas, Pablo; Peña Baquedano, Juan Antonio; Cilla, Myriam; Martinez, Miguel Ángel (Elsevier, 2019)
      Part of book or chapter of book
      Restricted access - publisher's policy
      Accurate determination of the tissue response after vascular surgeries or pathologies in patients requires developing appropriate models of the organ or vessel under consideration. In this regard, combining experimental ...
    • Mechanics reveals the biological trigger in wrinkly fingers 

      Sáez Viñas, Pablo; Zöllner, A. M. (2017-04)
      Article
      Open Access
      Fingertips wrinkle due to long exposure to water. The biological reason for this morphological change is unclear and still not fully understood. There are two main hypotheses for the underlying mechanism of fingertip ...
    • Mechanotransmission of haemodynamic forces by the endothelial glycocalyx in a full-scale arterial model 

      Sáez Viñas, Pablo; Gallo, Diego; Morbiducci, Umberto (2019-06-05)
      Article
      Open Access
      The glycocalyx has been identified as a key mechano-sensor of the shear forces exerted by streaming blood onto the vascular endothelial lining. Although the biochemical reaction to the blood flow has been extensively ...
    • Microstructural quantification of collagen fiber orientations and its integration in constitutive modeling of the porcine carotid artery 

      Sáez Viñas, Pablo; García, A.; Peña, Estefanía; Gasser, Thomas Christian; Martínez, M.A. (2016-03)
      Article
      Open Access
      Background Mechanical characteristics of vascular tissue may play a role in different arterial pathologies, which, amongst others, requires robust constitutive descriptions to capture the vessel wall’s anisotropic and ...
    • On the theories and numerics of continuum models for adaptation processes in biological tissues 

      Sáez Viñas, Pablo (2016-06)
      Article
      Open Access
      Computational continuum mechanics have been used for a long time to deal with the mechanics of materials. During the last decades researches have been using many of the theoretical models and numerical approaches of classical ...
    • On the use of the Bingham statistical distribution in microsphere-based constitutive models for arterial tissue 

      Alastrué, V.; Sáez Viñas, Pablo; Martínez, M.A,; Doblaré, Manuel (2010)
      Article
      Open Access
      Constitutive models for arterial tissue have been an active research field during the last years. The main micro-constituents of blood vessels are different types of cells and the extra-cellular matrix formed by an isotropic ...
    • Topological features dictate the mechanics of the mammalian brains 

      Sáez Viñas, Pablo; Duñó Nosas, Carles; Sun, L. Y.; Antonovaite, Nelda; Malve, M.; Tost Pardell, Daniela; Goriely, Alain (2020-12-01)
      Article
      Restricted access - publisher's policy
      Understanding brain mechanics is crucial in the study of pathologies involving brain deformations such as tumor, strokes, or in traumatic brain injury. Apart from the intrinsic mechanical properties of the brain tissue, ...