Now showing items 1-17 of 17

  • An anisotropic microsphere-based approach for fiber orientation adaptation in soft tissue 

    Sáez Viñas, Pablo; Pena, Estefanía; Doblaré, Manuel; Martínez, Miguel Ángel (2011)
    Article
    Open Access
    Evolutionary processes in biological tissue, such as adaptation or remodeling, represent an enterprising area of research. In this paper, we present a multiscale model for the remodeling of fibered structures, such as ...
  • Anisotropic microsphere-based approach to damage in soft fibered tissue 

    Sáez Viñas, Pablo; Alastrué, V.; Pena, Estefania; Doblaré, Manuel; Martínez, Miguel Ángel (2012-05)
    Article
    Open Access
    An anisotropic damage model for soft fibered tissue is presented in this paper, using a multi-scale scheme and focusing on the directionally dependent behavior of these materials. For this purpose, a micro-structural or, ...
  • A structural approach including the behavior of collagen cross-links to model patient-specific human carotid arteries 

    Sáez Viñas, Pablo; Peña, Estefanía; Martínez, Miguel Angel (2014)
    Article
    Open Access
    The objective of this work is to develop a remodeling model for biological matter coupling two different processes in a 3D framework: reorientation of the preferential direction of a given fibered structure and reorientation ...
  • A theoretical model of the endothelial cell morphology due to different waveforms 

    Sáez Viñas, Pablo; Malve, M.; Martínez, M.A. (2015-08)
    Article
    Open Access
    Endothelial cells are key units in the regulatory biological process of blood vessels. They represent an interface to transmit variations on the fluid dynamic changes. They are able to adapt its cytoskeleton, by means of ...
  • Bulging brains 

    Weickenmeie, J.; Sáez Viñas, Pablo; Butler, C. A.; Young, P.G.; Gorily, A.; Kuhl, Ellen (2016-10)
    Article
    Open Access
    Brain swelling is a serious condition associated with an accumulation of fluid inside the brain caused by trauma, stroke, infection, or tumors. It increases the pressure inside the skull and reduces blood and oxygen supply. ...
  • Computational modeling of acute myocardial infarction 

    Sáez Viñas, Pablo; Kuhl, E. (Gordon and Breach Science Publishers, 2016-07)
    Article
    Open Access
    Myocardial infarction, commonly known as heart attack, is caused by reduced blood supply and damages the heart muscle because of a lack of oxygen. Myocardial infarction initiates a cascade of biochemical and mechanical ...
  • Computational modeling of hypertensive growth in the human carotid artery 

    Sáez Viñas, Pablo; Peña, Estefanía; Martínez, Miguel Ángel; Kuhl, Ellen (2014-06)
    Article
    Open Access
    Arterial hypertension is a chronic medical condition associated with an elevated blood pressure. Chronic arterial hypertension initiates a series of events, which are known to collectively initiate arterial wall thickening. ...
  • Computational model of collagen turnover in carotid arteries during hypertension 

    Sáez Viñas, Pablo; Peña, Estefanía; Tarbell, J.M.; Martínez, Miguel Angel (John Wiley & Sons, Ltd, 2015-02)
    Article
    Open Access
    t is well known that biological tissues adapt their properties because of different mechanical and chemical stimuli. The goal of this work is to study the collagen turnover in the arterial tissue of hypertensive patients ...
  • Fully coupled numerical model of actin treadmilling in the lamellipodium of the cell 

    Kollepara, Kiran Sagar; Mulye, Paris D.; Sáez Viñas, Pablo (John Wiley & sons, 2018-12)
    Article
    Open Access
    Cells rely on an interplay of subcellular elements for motility and migration. Certain regions of motile cells, such as the lamellipodium, are made of a complex mixture of actin monomers and filaments, which polymerize at ...
  • Hierarchical micro-adaptation of biological structures by mechanical stimuli 

    Sáez Viñas, Pablo; Pena, Estefanía; Doblaré, Manuel; Martínez, Miguel Ángel (2013)
    Article
    Open Access
    Remodeling and other evolving processes such as growth or morphogenesis are key factors in the evolution of biological tissue in response to both external and internal epigenetic stimuli. Based on the description of these ...
  • Mathematical modeling of collagen turnover in biological tissue 

    Sáez Viñas, Pablo; Peña, Estefania; Martínez, Miguel Àngel; Kuhl, Ellen (2012)
    Article
    Open Access
    We present a theoretical and computational model for collagen turnover in soft biological tissues. Driven by alterations in the mechanical environment, collagen fiber bundles may undergo important chronic changes, characterized ...
  • Mechanics reveals the biological trigger in wrinkly fingers 

    Sáez Viñas, Pablo; Zöllner, A. M. (2017-04)
    Article
    Open Access
    Fingertips wrinkle due to long exposure to water. The biological reason for this morphological change is unclear and still not fully understood. There are two main hypotheses for the underlying mechanism of fingertip ...
  • Mechanotransmission of haemodynamic forces by the endothelial glycocalyx in a full-scale arterial model 

    Sáez Viñas, Pablo; Gallo, Diego; Morbiducci, Umberto (2019-06-05)
    Article
    Open Access
    The glycocalyx has been identified as a key mechano-sensor of the shear forces exerted by streaming blood onto the vascular endothelial lining. Although the biochemical reaction to the blood flow has been extensively ...
  • Microstructural quantification of collagen fiber orientations and its integration in constitutive modeling of the porcine carotid artery 

    Sáez Viñas, Pablo; García, A.; Peña, Estefanía; Gasser, Thomas Christian; Martínez, M.A. (2016-03)
    Article
    Open Access
    Background Mechanical characteristics of vascular tissue may play a role in different arterial pathologies, which, amongst others, requires robust constitutive descriptions to capture the vessel wall’s anisotropic and ...
  • On the theories and numerics of continuum models for adaptation processes in biological tissues 

    Sáez Viñas, Pablo (2016-06)
    Article
    Open Access
    Computational continuum mechanics have been used for a long time to deal with the mechanics of materials. During the last decades researches have been using many of the theoretical models and numerical approaches of classical ...
  • On the use of the Bingham statistical distribution in microsphere-based constitutive models for arterial tissue 

    Alastrué, V.; Sáez Viñas, Pablo; Martínez, M.A,; Doblaré, Manuel (2010)
    Article
    Open Access
    Constitutive models for arterial tissue have been an active research field during the last years. The main micro-constituents of blood vessels are different types of cells and the extra-cellular matrix formed by an isotropic ...
  • Towards the modelling of ageing and atherosclerosis effects in ApoE-/- mice aortic tissue 

    Waffenschmidt, T., Tobias; Cilla, Myriam; Sáez Viñas, Pablo; Pérez, Marta M.; Menzel, Andreas; Peña, E. (2016-08-16)
    Article
    Open Access
    The goal of this work consists in a quantitative analysis and constitutive modelling of ageing processes associated to plaque formation in mice arteries. Reliable information on the characteristic evolution of pressure–stretch ...