Browsing by Author "Gómez Gutiérrez, Patricia"
Now showing items 1-6 of 6
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Assessment of the conformational profile of bombesin by computational methods
(2020-07-20)
Article
Restricted access - publisher's policyIn the present work, the results of a computational study aimed at assessing the conformational profile of bombesin are reported. The conformational space of the peptide was sampled by means of a 4 µs accelerated molecular ... -
Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-beta-Induced Neuronal Death
(2016-01-01)
Article
Open AccessAstrocytes actively participate in neuro-inflammatory processes associated to Alzheimer's disease (AD), and other brain pathologies. We recently showed that an astrocyte-specific intracellular signaling pathway involving ... -
Discovery of a bradykinin b2 partial agonist profile of raloxifene in a drug repurposing campaign
(2020-12-29)
Article
Open AccessCovid-19 urges a deeper understanding of the underlying molecular mechanisms involved in illness progression to provide a prompt therapeutical response with an adequate use of available drugs, including drug repurposing. ... -
Molecular determinants of the bacterial resistance to fluoroquinolones: A computational study
(2013-06-13)
Article
Open AccessAbstract: Quinolones constitute a large class of antibacterial agents whose action is mediated through the formation of a ternary complex with DNA and either, DNA Gyrase or topoisomerase IV, resulting in the inhibition ... -
New insights into the stereochemical requirements of the bombesin BB1 receptor antagonists binding
(2020-08-17)
Article
Open AccessMembers of the family of bombesinlike peptides exert a wide range of biological activities both at the central nervous system and in peripheral tissues through at least three G-Protein Coupled Receptors: BB1, BB2 and BB3. ... -
Using molecular dynamics for the refinement of atomistic models of GPCRs by homology modeling
(2017-08-13)
Article
Open AccessDespite GPCRs sharing a common seven helix bundle, analysis of the diverse crystallographic structures available reveal specific features that might be relevant for ligand design. Despite the number of crystallographic ...
