Exploració per autor "Pancaldi, Vera"
Ara es mostren els items 1-14 de 14
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Automatic identification of informative regions with epigenomic changes associated to hematopoiesis
Carrillo-de-Santa-Pau, Enrique; Juan, David; Pancaldi, Vera; Were, Felipe; Martin-Subero, Ignacio; Rico, Daniel; Valencia, Alfonso (Oxford University Press, 2017-09-19)
Article
Accés obertHematopoiesis is one of the best characterized biological systems but the connection between chromatin changes and lineage differentiation is not yet well understood. We have developed a bioinformatic workflow to generate ... -
Chromatin 3D organization revealed by chromatin networks: gene-regulation, replication, and beyond
Pancaldi, Vera (Barcelona Supercomputing Center, 2019)
Altres
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Chromatin network markers of leukemia
Malod-Dognin, Noel; Pancaldi, Vera; Valencia, Alfonso; Pržulj, Natasa (Oxford University Press, 2020-07)
Article
Accés obertMotivation The structure of chromatin impacts gene expression. Its alteration has been shown to coincide with the occurrence of cancer. A key challenge is in understanding the role of chromatin structure (CS) in cellular ... -
Community-wide hackathons to identify central themes in single-cell multi-omics
Cao, Kim-Anh Lê; Abadi, Al J.; Davis-Marcisak, Emily F.; Hsu, Lauren; Arora, Arshi; Pancaldi, Vera (BioMed Central (BMC), 2021)
Article
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CovMulNet19, Integrating Proteins, Diseases, Drugs, and Symptoms: A Network Medicine Approach to COVID-19
Verstraete, Nina; Jurman, Giuseppe; Bertagnolli, Giulia; Ghavasieh, Arsham; Pancaldi, Vera; Domenico, Manlio De (Mary Ann Liebert, 2020)
Article
Accés obertIntroduction: We introduce in this study CovMulNet19, a comprehensive COVID-19 network containing all available known interactions involving SARS-CoV-2 proteins, interacting-human proteins, diseases and symptoms that are ... -
Cytidine Deaminase Resolves Replicative Stress and Protects Pancreatic Cancer from DNA-Targeting Drugs
Lumeau, Audrey; Bery, Nicolas; Francès, Audrey; Gayral, Marion; Labrousse, Guillaume; Pancaldi, Vera (American Association for Cancer Research, 2024)
Article
Accés obertCytidine deaminase (CDA) functions in the pyrimidine salvage pathway for DNA and RNA syntheses and has been shown to protect cancer cells from deoxycytidine-based chemotherapies. In this study, we observed that CDA was ... -
Epigenetic and Transcriptional Variability Shape Phenotypic Plasticity
Ecker, Simone; Pancaldi, Vera; Valencia, Alfonso; Beck, Stephan; Paul, Dirk S. (Wiley, 2017-12-18)
Article
Accés obertEpigenetic and transcriptional variability contribute to the vast diversity of cellular and organismal phenotypes and are key in human health and disease. In this review, we describe different types, sources, and determinants ... -
Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker
Johansson, Patricia; Laguna, Teresa; Ossowski, Julio; Pancaldi, Vera; Brauser, Martina (BioMed Central (BMC), 2022-11)
Article
Accés obertBackground The molecular pathogenesis of T-cell large granular lymphocytic leukemia (T-LGLL), a mature T-cell leukemia arising commonly from T-cell receptor αβ-positive CD8+ memory cytotoxic T cells, is only partly ... -
Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker
Johansson, Patricia; Laguna, Teresa; Ossowski, Julio; Pancaldi, Vera; Brauser, Martina (BioMed Central (BMC), 2022)
Article
Accés obertBackground The molecular pathogenesis of T-cell large granular lymphocytic leukemia (T-LGLL), a mature T-cell leukemia arising commonly from T-cell receptor αβ-positive CD8+ memory cytotoxic T cells, is only partly ... -
Interpreting molecular similarity between patients as a determinant of disease comorbidity relationships
Sánchez, Jon; Tejero, Héctor; Fernández, José María; Juan, David; Urda García, Beatriz; Capella Gutiérrez, Salvador; Al-Shahrour, Fátima; Tabarés Seisdedos, Rafael; Baudot, Anais; Pancaldi, Vera; Valencia, Alfonso (Springer Nature, 2020)
Article
Accés obertComorbidity is a medical condition attracting increasing attention in healthcare and biomedical research. Little is known about the involvement of potential molecular factors leading to the emergence of a specific disease ... -
Low replicative stress triggers cell-type specific inheritable advanced replication timing
Courtot, Lilas; Bournique, Elodie; Maric, Chrystelle; Guitton Sert, Laure; Madrid Mencía, Miguel; Pancaldi, Vera; Cadoret, Jean-Charles; Hoffmann, Jean-Sébastien; Bergoglio, Valérie (MDPI, 2021)
Article
Accés obertDNA replication timing (RT), reflecting the temporal order of origin activation, is known as a robust and conserved cell-type specific process. Upon low replication stress, the slowing of replication forks induces ... -
STAG2 loss-of-function affects short-range genomic contacts and modulates the basal-luminal transcriptional program of bladder cancer cells
Richart, Laia; Lapi, Eleonora; Pancaldi, Vera; Cuenca Ardura, Mirabai; Carrillo de Santa Pau, Enrique; Madrid, Miguel; Serra, François; Valencia, Alfonso (Oxford University Press, 2021-10-14)
Article
Accés obertCohesin exists in two variants containing STAG1 or STAG2. STAG2 is one of the most mutated genes in cancer and a major bladder tumor suppressor. Little is known about how its inactivation contributes to tumorigenesis. Here, ... -
Unveiling new disease, pathway, and gene associations via multi-scale neural network
Gaudelet, Thomas; Malod Dognin, Noël; Sánchez, Jon; Pancaldi, Vera; Valencia, Alfonso; Pržulj, Nataša (PLOS, 2020-04-06)
Article
Accés obertDiseases involve complex modifications to the cellular machinery. The gene expression profile of the affected cells contains characteristic patterns linked to a disease. Hence, new biological knowledge about a disease can ... -
Using GARDEN-NET and ChAseR to explore human haematopoietic 3D chromatin interaction networks
Madrid, Miguel; Raineri, Emanuele; Cao, Tran Bich Ngoc; Pancaldi, Vera (Oxford University Press (OUP), 2020-05-07)
Article
Accés obertWe introduce an R package and a web-based visualization tool for the representation, analysis and integration of epigenomic data in the context of 3D chromatin interaction networks. GARDEN-NET allows for the projection of ...