Now showing items 1-20 of 34

  • A General Equilibrium Model to Study Intracellular Calcium Homeostasis. New Insights on Ventricular Function 

    Álvarez Lacalle, Enrique; Conesa, David; Echebarría Domínguez, Blas; Shiferaw, Yohannes; Peñaranda Ayllón, Angelina; Rodríguez Cantalapiedra, Inma (2018)
    Conference report
    Open Access
  • Amplitude equation approach to spatiotemporal dynamics of cardiac alternans 

    Echebarría Domínguez, Blas; Karma, Alain (American Physical Society, 2007-11-30)
    Article
    Open Access
    Amplitude equations are derived that describe the spatiotemporal dynamics of cardiac alternans during periodic pacing of one- B. Echebarria and A. Karma, Phys. Rev. Lett. 88, 208101 2002 and twodimensional homogeneous ...
  • Are SR Ca content fluctuations or SR refractoriness the key to atrial cardiac alternans?: insights from a human atrial model 

    Lugo Vélez, Carlos Antonio; Rodríguez Cantalapiedra, Inma; Peñaranda Ayllón, Angelina; Hove-Madsen, Leif; Echebarría Domínguez, Blas (2014-06-01)
    Article
    Restricted access - publisher's policy
    Despite the important role of electromechanical alternans in cardiac arrhythmogenesis, its molecular origin is not well understood. The appearance of calcium alternans has often been associated to fluctuations in the ...
  • Calcium alternans is a global order-disorder phase transition: robustness on ryanodine receptor release dynamics 

    Álvarez Lacalle, Enrique; Peñaranda Ayllón, Angelina; Rodríguez Cantalapiedra, Inma; Shiferaw, Yohannes; Echebarría Domínguez, Blas (2016-01-01)
    Article
    Open Access
    Electromechanical alternans is a beat-to-beat alterna- tion in the strength of contraction of a cardiac cell which appears often due to an instability of calcium cycling. The global calcium signal in cardiomyocytes is ...
  • Calcium alternans is a global order-disorder phase transition. Robustness on Ryanodine Receptor release dynamics 

    Álvarez Lacalle, Enrique; Peñaranda Ayllón, Angelina; Rodríguez Cantalapiedra, Inma; Shiferaw, Yohannes; Echebarría Domínguez, Blas (2015)
    Conference report
    Open Access
    Electromechanical alternans is a beat-to-beat alterna- tion in the strength of contraction of a cardiac cell which appears often due to an instability of calcium cycling. The global calcium signal in cardiomyocytes is ...
  • Calcium Alternans is Due to an Order-Disorder Phase Transition in Cardiac Cells 

    Álvarez Lacalle, Enrique; Echebarría Domínguez, Blas; Spalding, Jon; Shiferaw, Yohannes (2015-03-12)
    Article
    Open Access
    Electromechanical alternans is a beat-to-beat alternation in the strength of contraction of a cardiac cell, which can be caused by an instability of calcium cycling. Using a distributed model of subcellular calcium we show ...
  • Calcium alternans produced by increased sarcoplasmic reticulum refractoriness 

    Rodríguez Cantalapiedra, Inma; Lugo Vélez, Carlos Antonio; Peñaranda Ayllón, Angelina; Echebarría Domínguez, Blas (2011-09-29)
    Article
    Open Access
    Despite the important role of electro-mechanical alternans in cardiac arrhythmogenesis, its molecular origin is not well understood. In this paper we want to study alternans that can be associated with alternations in the ...
  • Calcium alternans produced by increased sarcoplasmic reticulum refractoriness 

    Rodríguez Cantalapiedra, Inma; Lugo, Carlos; Peñaranda Ayllón, Angelina; Echebarría Domínguez, Blas (IEEE Computer Society Publications, 2011)
    Conference report
    Restricted access - publisher's policy
    Despite the important role of electro-mechanical alternans in cardiac arrhythmogenesis, its molecular origin is not well understood. In this paper we want to study alternans that can be associated with alternations in ...
  • Cardiac contraction induces discordant alternans and localized block 

    Radszuweit, M.; Álvarez Lacalle, Enrique; Bär, Markus; Echebarría Domínguez, Blas (2015-02-04)
    Article
    Open Access
    In this paper we use a simplified model of cardiac excitation-contraction coupling to study the effect of tissue deformation on the dynamics of alternans, i.e., alternations in the duration of the cardiac action potential, ...
  • Cardiac dynamics: modeling the Brugada syndrome 

    Rodríguez Cantalapiedra, Inma; Echebarría Domínguez, Blas; Peñaranda Ayllón, Angelina (2007)
    Conference report
    Open Access
    Este trabajo analiza mediante un modelo matemático reducido de corrientes ionicas la posibilidad de aparición de arritmias cardiacas.
  • Computational Model of Calcium Signaling in Cardiac Atrial Cells at the Submicron Scale 

    Marchena Angos, Miquel; Echebarría Domínguez, Blas (2018-12-10)
    Article
    Open Access
    In cardiac cells, calcium is the mediator of excitation-contraction coupling. Dysfunctions in calcium handling have been identified as the origin of some cardiac arrhythmias. In the particular case of atrial myocytes, ...
  • Dependency of calcium alternans on Ryanodine Receptor Refractoriness 

    Álvarez Lacalle, Enrique; Rodríguez Cantalapiedra, Inma; Peñaranda Ayllón, Angelina; Cinca, J.; Hove-Madsen, Leif; Echebarría Domínguez, Blas (2013-02-04)
    Article
    Open Access
    Background Rapid pacing rates induce alternations in the cytosolic calcium concentration caused by fluctuations in calcium rele However, the relationship between calcium alternans and refractoriness of the SR calcium ...
  • Effect of RyR2 refractoriness and hypercalcemia on calcium overload, spontaneous release, and calcium alternans 

    Álvarez Lacalle, Enrique; Peñaranda Ayllón, Angelina; Rodríguez Cantalapiedra, Inma; Hove-Madsen, Leif; Echebarría Domínguez, Blas (2013)
    Article
    Restricted access - publisher's policy
    In this work we use a computer model of a ventricular rabbit myocyte to study several factors that affect sarcoplasmic reticulum (SR) calcium load, such as hypercalcemia, SR calcium buffering, or ryanodine receptor ...
  • Effects of small conductance calcium activated potassium channels in atrial myocytes 

    Peñaranda Ayllón, Angelina; Echebarría Domínguez, Blas; Álvarez Lacalle, Enrique; Rodríguez Cantalapiedra, Inma (IEEE Computer Society Conference Publishing Services (CPS), 2017)
    Conference lecture
    Open Access
    Among the different potassium channels present in cardiac myocytes, the small conductance Ca2+ activated potassium channels (SK channels) are particular because they are affected by changes in intracellular calcium. The ...
  • Influence of gap junction dynamics on the stability of reentrant waves in cadiac tissue 

    Hawks, Claudia; Elorza Barbajero, Jorge; Echebarría Domínguez, Blas; Rodríguez Cantalapiedra, Inma; Peñaranda Ayllón, Angelina; Bragard, Jean (2015)
    Conference report
    Open Access
    Constant conductances are often assumed when model- ing cardiac tissue. However experimental evidences have shown that gap junctions (GJ) actually connect adjacent cardiac myocytes. These GJ are complex proteins of ...
  • Influence of gap junction dynamics on the stability of reentrant waves in cardiac tissue 

    Hawks, Claudia; Elorza Barbajero, Jorge; Echebarría Domínguez, Blas; Rodríguez Cantalapiedra, Inma; Peñaranda Ayllón, Angelina; Bragard, Jean (2016-01-01)
    Conference lecture
    Open Access
    Constant conductances are often assumed when model- ing cardiac tissue. However experimental evidences have shown that gap junctions (GJ) actually connect adjacent cardiac myocytes. These GJ are complex proteins of ...
  • Instability and spatiotemporal dynamics of alternans in paced cardiac tissue 

    Echebarría Domínguez, Blas; Karma, Alain (2002)
    Article
    Open Access
    We derive an equation that governs the spatiotemporal dynamics of small amplitude alternans in paced cardiac tissue. We show that a pattern-forming linear instability leads to the spontaneous formation of stationary or ...
  • Mechanisms for initiation of cardiac discordant alternans 

    Echebarría Domínguez, Blas; Karma, Alain (Springer, 2007-07-31)
    Article
    Restricted access - publisher's policy
    Electrical alternans, defined as a beat-to-beat change in the duration of the excited phase of cardiac cells, is among the known precursors of sudden cardiac death. It may appear as concordant (all the tissue presenting ...
  • Mechanisms Underlying Electro-Mechanical Cardiac Alternans 

    Echebarría Domínguez, Blas; Álvarez Lacalle, Enrique; Rodríguez Cantalapiedra, Inma; Peñaranda Ayllón, Angelina (Springer, 2016-02-29)
    Part of book or chapter of book
    Restricted access - publisher's policy
    Electro-mechanical cardiac alternans consists in beat-to-beat changes in the strength of cardiac contraction. Despite its important role in cardiac arrhythmogenesis, its molecular origin is not well understood. The appearance ...
  • Minimal model for calcium alternans due to SR release refractoriness 

    Rodríguez Cantalapiedra, Inma; Álvarez Lacalle, Enrique; Peñaranda Ayllón, Angelina; Echebarría Domínguez, Blas (Institute of Physics (IOP), 2017-09-07)
    Article
    Open Access
    In the heart, rapid pacing rates may induce alternations in the strength of cardiac contraction, termed pulsus alternans. Often, this is due to an instability in the dynamics of the intracellular calcium concentration, ...