Now showing items 1-20 of 37

    • A General Equilibrium Model to Study Intracellular Calcium Homeostasis. New Insights on Ventricular Function 

      Álvarez Lacalle, Enrique; Conesa, David; Echebarría Domínguez, Blas; Shiferaw, Yohannes; Peñaranda Ayllón, Angelina; Rodríguez Cantalapiedra, Inma (2018)
      Conference report
      Open Access
    • Amplitude equation approach to spatiotemporal dynamics of cardiac alternans 

      Echebarría Domínguez, Blas; Karma, Alain (American Physical Society, 2007-11-30)
      Article
      Open Access
      Amplitude equations are derived that describe the spatiotemporal dynamics of cardiac alternans during periodic pacing of one- B. Echebarria and A. Karma, Phys. Rev. Lett. 88, 208101 2002 and twodimensional homogeneous ...
    • Are SR Ca content fluctuations or SR refractoriness the key to atrial cardiac alternans?: insights from a human atrial model 

      Lugo Vélez, Carlos Antonio; Rodríguez Cantalapiedra, Inma; Peñaranda Ayllón, Angelina; Hove-Madsen, Leif; Echebarría Domínguez, Blas (2014-06-01)
      Article
      Restricted access - publisher's policy
      Despite the important role of electromechanical alternans in cardiac arrhythmogenesis, its molecular origin is not well understood. The appearance of calcium alternans has often been associated to fluctuations in the ...
    • Calcium alternans is a global order-disorder phase transition. Robustness on Ryanodine Receptor release dynamics 

      Álvarez Lacalle, Enrique; Peñaranda Ayllón, Angelina; Rodríguez Cantalapiedra, Inma; Shiferaw, Yohannes; Echebarría Domínguez, Blas (2015)
      Conference report
      Open Access
      Electromechanical alternans is a beat-to-beat alterna- tion in the strength of contraction of a cardiac cell which appears often due to an instability of calcium cycling. The global calcium signal in cardiomyocytes is ...
    • Calcium alternans is a global order-disorder phase transition: robustness on ryanodine receptor release dynamics 

      Álvarez Lacalle, Enrique; Peñaranda Ayllón, Angelina; Rodríguez Cantalapiedra, Inma; Shiferaw, Yohannes; Echebarría Domínguez, Blas (2016-01-01)
      Article
      Open Access
      Electromechanical alternans is a beat-to-beat alterna- tion in the strength of contraction of a cardiac cell which appears often due to an instability of calcium cycling. The global calcium signal in cardiomyocytes is ...
    • Calcium Alternans is Due to an Order-Disorder Phase Transition in Cardiac Cells 

      Álvarez Lacalle, Enrique; Echebarría Domínguez, Blas; Spalding, Jon; Shiferaw, Yohannes (2015-03-12)
      Article
      Open Access
      Electromechanical alternans is a beat-to-beat alternation in the strength of contraction of a cardiac cell, which can be caused by an instability of calcium cycling. Using a distributed model of subcellular calcium we show ...
    • Calcium alternans produced by increased sarcoplasmic reticulum refractoriness 

      Rodríguez Cantalapiedra, Inma; Lugo Vélez, Carlos Antonio; Peñaranda Ayllón, Angelina; Echebarría Domínguez, Blas (2011-09-29)
      Article
      Open Access
      Despite the important role of electro-mechanical alternans in cardiac arrhythmogenesis, its molecular origin is not well understood. In this paper we want to study alternans that can be associated with alternations in the ...
    • Calcium alternans produced by increased sarcoplasmic reticulum refractoriness 

      Rodríguez Cantalapiedra, Inma; Lugo, Carlos; Peñaranda Ayllón, Angelina; Echebarría Domínguez, Blas (IEEE Computer Society Publications, 2011)
      Conference report
      Restricted access - publisher's policy
      Despite the important role of electro-mechanical alternans in cardiac arrhythmogenesis, its molecular origin is not well understood. In this paper we want to study alternans that can be associated with alternations in ...
    • Cardiac contraction induces discordant alternans and localized block 

      Radszuweit, M.; Álvarez Lacalle, Enrique; Bär, Markus; Echebarría Domínguez, Blas (2015-02-04)
      Article
      Open Access
      In this paper we use a simplified model of cardiac excitation-contraction coupling to study the effect of tissue deformation on the dynamics of alternans, i.e., alternations in the duration of the cardiac action potential, ...
    • Cardiac dynamics: modeling the Brugada syndrome 

      Rodríguez Cantalapiedra, Inma; Echebarría Domínguez, Blas; Peñaranda Ayllón, Angelina (2007)
      Conference report
      Open Access
      Este trabajo analiza mediante un modelo matemático reducido de corrientes ionicas la posibilidad de aparición de arritmias cardiacas.
    • Computational Model of Calcium Signaling in Cardiac Atrial Cells at the Submicron Scale 

      Marchena Angos, Miquel; Echebarría Domínguez, Blas (2018-12-10)
      Article
      Open Access
      In cardiac cells, calcium is the mediator of excitation-contraction coupling. Dysfunctions in calcium handling have been identified as the origin of some cardiac arrhythmias. In the particular case of atrial myocytes, ...
    • Dependency of calcium alternans on Ryanodine Receptor Refractoriness 

      Álvarez Lacalle, Enrique; Rodríguez Cantalapiedra, Inma; Peñaranda Ayllón, Angelina; Cinca, J.; Hove-Madsen, Leif; Echebarría Domínguez, Blas (2013-02-04)
      Article
      Open Access
      Background Rapid pacing rates induce alternations in the cytosolic calcium concentration caused by fluctuations in calcium rele However, the relationship between calcium alternans and refractoriness of the SR calcium ...
    • Effect of RyR2 refractoriness and hypercalcemia on calcium overload, spontaneous release, and calcium alternans 

      Álvarez Lacalle, Enrique; Peñaranda Ayllón, Angelina; Rodríguez Cantalapiedra, Inma; Hove-Madsen, Leif; Echebarría Domínguez, Blas (2013)
      Article
      Restricted access - publisher's policy
      In this work we use a computer model of a ventricular rabbit myocyte to study several factors that affect sarcoplasmic reticulum (SR) calcium load, such as hypercalcemia, SR calcium buffering, or ryanodine receptor ...
    • Effects of small conductance calcium activated potassium channels in atrial myocytes 

      Peñaranda Ayllón, Angelina; Echebarría Domínguez, Blas; Álvarez Lacalle, Enrique; Rodríguez Cantalapiedra, Inma (IEEE Computer Society Conference Publishing Services (CPS), 2017)
      Conference lecture
      Open Access
      Among the different potassium channels present in cardiac myocytes, the small conductance Ca2+ activated potassium channels (SK channels) are particular because they are affected by changes in intracellular calcium. The ...
    • Gap junction dynamics induces localized conductance bistability in cardiac tissue 

      Hawks, Claudia; Elorza Barbajero, Jorge; Witt, Annette; Laroze, David; Rodríguez Cantalapiedra, Inma; Peñaranda Ayllón, Angelina; Echebarría Domínguez, Blas; Bragard, Jean (2019-07-01)
      Article
      Open Access
      Connexins are specialized ionic channels that control the action potential propagation between cardiac myocytes. In this paper, we study the connexin dynamics in a one-dimensional model of cardiac tissue. We show that the ...
    • Influence of gap junction dynamics on the stability of reentrant waves in cadiac tissue 

      Hawks, Claudia; Elorza Barbajero, Jorge; Echebarría Domínguez, Blas; Rodríguez Cantalapiedra, Inma; Peñaranda Ayllón, Angelina; Bragard, Jean (2015)
      Conference report
      Open Access
      Constant conductances are often assumed when model- ing cardiac tissue. However experimental evidences have shown that gap junctions (GJ) actually connect adjacent cardiac myocytes. These GJ are complex proteins of ...
    • Influence of gap junction dynamics on the stability of reentrant waves in cardiac tissue 

      Hawks, Claudia; Elorza Barbajero, Jorge; Echebarría Domínguez, Blas; Rodríguez Cantalapiedra, Inma; Peñaranda Ayllón, Angelina; Bragard, Jean (2016-01-01)
      Conference lecture
      Open Access
      Constant conductances are often assumed when model- ing cardiac tissue. However experimental evidences have shown that gap junctions (GJ) actually connect adjacent cardiac myocytes. These GJ are complex proteins of ...
    • Influence of the tubular network on the characteristics of calcium transients in cardiac myocytes 

      Marchena Angos, Miquel; Echebarría Domínguez, Blas (Public Library of Science (PLOS), 2020-04-17)
      Article
      Open Access
      Transverse and axial tubules (TATS) are an essential ingredient of the excitation-contraction machinery that allow the effective coupling of L-type Calcium Channels (LCC) and ryanodine receptors (RyR2). They form a regular ...
    • Instability and spatiotemporal dynamics of alternans in paced cardiac tissue 

      Echebarría Domínguez, Blas; Karma, Alain (2002)
      Article
      Open Access
      We derive an equation that governs the spatiotemporal dynamics of small amplitude alternans in paced cardiac tissue. We show that a pattern-forming linear instability leads to the spontaneous formation of stationary or ...
    • Mechanisms for initiation of cardiac discordant alternans 

      Echebarría Domínguez, Blas; Karma, Alain (Springer, 2007-07-31)
      Article
      Restricted access - publisher's policy
      Electrical alternans, defined as a beat-to-beat change in the duration of the excited phase of cardiac cells, is among the known precursors of sudden cardiac death. It may appear as concordant (all the tissue presenting ...