Now showing items 1-6 of 6

    • B2D2- La integración de las técnicas biofísicas en el descubrimiento de fármacos 

      Aymami Bofarull, Juan; Martinell, Marc (2008-07-16)
      Article
      Open Access
    • Enzyme enhancement therapy through non-competitive pharmacological chaperones 

      Aymami Bofarull, Juan; Barril, Xavier; Delgado, Aida; Reves, Marc; Lavilla, Rodolfo; Higaki, Katsumi; García-Collazo, Anan Maria; Rodríguez-Pascau, Laura; Cubero, Elena; Pizcueta, Pilar; Martinell, Marc (2014)
      Conference report
      Open Access
      Most Pharmacological chaperones (PC’s) described until now are substrate analogues which bind to the active site of the target protein. C ons e- quently, such PC’s also inhibit the target protein at higher concentrations ...
    • Intercalative DNA binding of the marine anticancer drug variolin B 

      Canals, Albert; Arribas Bosacoma, Raquel; Albericio Palomera, Fernando; Alvarez Domingo, Mercedes; Aymami Bofarull, Juan; Coll, Miquel (Macmillan Publishers, 2017-01-04)
      Article
      Open Access
      Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic ...
    • Micro-molding with ultrasonic vibration energy: New method to disperse nanoclays in polymer matrices 

      Planellas Oates, Marc; Sacristan, Matias; Rey, Lorena; Olmo Osuna, Cristian; Aymami Bofarull, Juan; Casas Becerra, María Teresa; Valle Mendoza, Luis Javier del; Franco García, María Lourdes; Puiggalí Bellalta, Jordi (2014-07)
      Article
      Restricted access - publisher's policy
      Ultrasound technology was proved as an efficient processing technique to obtain micro-molded specimens of polylactide (PLA) and polybutylene succinate (PBS), which were selected as examples of biodegradable polyesters ...
    • Preparation of micro-molded exfoliated clay nanocomposites by means of ultrasonic technology 

      Díaz Andrade, Angélica María; Franco García, María Lourdes; Casas Becerra, María Teresa; Valle Mendoza, Luis Javier del; Aymami Bofarull, Juan; Olmo Osuna, Cristian; Puiggalí Bellalta, Jordi (2014-10-15)
      Article
      Restricted access - publisher's policy
      Ultrasound micro-molding technology has been tested as a new method to get polymer/clay nanocomposites. Biodegradable polylactide (PLA) and poly (nona-methylene azelate) (PE99) have been used as polymer matrices, whereas ...
    • Uso de la cristalografia de rayos X en el Drug Discovery 

      Bonin, Irena; Martinell, Marc; Aymami Bofarull, Juan (2009-03-13)
      Article
      Open Access