Now showing items 1-20 of 73

    • A new approach for sizing trials with composite binary endpoints using anticipated marginal values and accounting for the correlation between components 

      Bofill Roig, Marta; Gómez Melis, Guadalupe (2019-05-20)
      Article
      Open Access
      Composite binary endpoints are increasingly used as primary endpoints in clinical trials. When designing a trial, it is crucial to determine the appropriate sample size for testing the statistical differences between ...
    • A nonparametric test for the association between longitudinal covariates and censored survival data 

      Oller Piqué, Ramón; Gómez Melis, Guadalupe (Oxford University Press, 2020-10-01)
      Article
      Restricted access - publisher's policy
      Many biomedical studies focus on the association between a longitudinal measurement and a time-to-event outcome while quantifying this association by means of a longitudinal-survival joint model. In this article we propose ...
    • A semi-parametric joint model for two sequential times to events and one longitudinal covariate 

      Serrat Piè, Carles; Abel Huertas, Jaime; Gómez Melis, Guadalupe (2012)
      Conference lecture
      Open Access
      The present work proposes a joint model for two sequential times to events together with longitudinal information, as an extension of the joint model by Wolfsohn and Tsiatis (1997) for one time to event and one longitudinal ...
    • A shared-parameter joint model for prostate cancer risk and psa longitudinal profiles 

      Serrat Piè, Carles; Rué, Montserrat; Perpiñán Fabuel, Hèctor; Forte, Anabel; Armero, Carmen; Piulachs, Xavier; Páez, Álvaro; Gómez Melis, Guadalupe (Fundación Mapfre, 2015)
      Conference report
      Open Access
      The paper describes the use of frequentist and Bayesian shared-parameter joint models of longitudinal measurements of prostate specific antigen (PSA) and the risk of prostate cancer (PCa). The motivating dataset corresponds ...
    • Advanced Statistical Inference 

      Gómez Melis, Guadalupe; Sánchez Pla, Àlex (Universitat Politècnica de Catalunya, 2017-01-11)
      Exam
      Restricted access to the UPC academic community
    • Analyzing left-truncated and right-censored infectious disease cohort data with interval-censored infection onset 

      Pak, Daewoo; Liu, Jun; Ning, Jing; Gómez Melis, Guadalupe; Shen, Yu (2021-01-01)
      Article
      Restricted access - publisher's policy
      n an infectious disease cohort study, individuals who have been infected with apathogenare often recruited for follow up. The period between infection and the onset of symptomatic disease, referred to as the incubation ...
    • ANÀLISI DE LA SUPERVIVÈNCIA 

      Gómez Melis, Guadalupe (Universitat Politècnica de Catalunya, 2012-01-11)
      Exam
      Restricted access to the UPC academic community
    • ANÀLISI DE LA SUPERVIVÈNCIA 

      Gómez Melis, Guadalupe (Universitat Politècnica de Catalunya, 2011-01-10)
      Exam
      Restricted access to the UPC academic community
    • ANÀLISI DE TEMPS DE VIDA 

      Gómez Melis, Guadalupe (Universitat Politècnica de Catalunya, 2016-01-12)
      Exam
      Restricted access to the UPC academic community
    • ANÀLISI DE TEMPS DE VIDA 

      Gómez Melis, Guadalupe (Universitat Politècnica de Catalunya, 2016-01-12)
      Exam
      Restricted access to the UPC academic community
    • Association of premenopausal risk-reducing salpingo-oophorectomy with breast cancer risk in BRCA1/2 mutation carriers: maximising bias-reduction 

      Stjepanovic, Neda; Villacampa, Guillermo; Gómez Melis, Guadalupe (2020-06-01)
      Article
      Open Access
      Background. Whether risk-reducing salpingo-oophorectomy (RRSO) in BRCA1/2 carriers reduces the breast cancer (BC) risk is conflicting, potentially due to methodological issues of prior analysis. We analysed the association ...
    • Bayesian joint ordinal and survival modeling for breast cancer risk assessment 

      Armero, Carmen; Forné, Carles; Rué, Montserrat; Forte Deltell, Anabel; Perpiñán Fabuel, Hèctor; Gómez Melis, Guadalupe; Bare Mañas, Maris (2016-12-10)
      Article
      Open Access
      We propose a joint model to analyze the structure and intensity of the association between longitudinal measurements of an ordinal marker and time to a relevant event. The longitudinal process is defined in terms of a ...
    • Biometría: Estudios de supervivencia con datos no observados. Dificultades inherentes al enfoque paramétrico 

      Gómez Melis, Guadalupe; Serrat Piè, Carles (Institut d'Estadística de Catalunya, 1999)
      Article
      Open Access
      A partir de una muestra de datos de supervivencia que contiene valores no observados en las covariantes de interés, presentamos una metodología que permite extraer toda la información contenida en covariantes completamente ...
    • BioStatNet: an interdisciplinary biostatistics network 

      Bayarri García, María Jesús; Cadarso Suárez, Carmen; Durbán Reguera, María Luz; Gómez Melis, Guadalupe; López Fidalgo, Jesús; Martín Andrés, Antonio; Nuñez Antón, Vicente; Puig Casado, Pere (Sociedad de Estadística e Investigación Operativa (SEIO), 2012-06)
      Article
      Open Access
      Biostatistics has become a major scientific component of biomedical research with a strong interdisciplinary basis. This endeavour is essentially interdisciplinary, therefore, training of future biostatisticians must ...
    • Clinical trial designs using CompARE. An on-line exploratory tool for investigators 

      Gómez Mateu, Moisés; Gómez Melis, Guadalupe (2017-03)
      External research report
      Open Access
      Conclusions from randomized clinical trials (RCT) rely primarily on the primary endpoint (PE) chosen at the design stage of the study. There should generally be only one PE which should be able to provide the most clinically ...
    • Competing risks methods 

      Porta Bleda, Núria; Gómez Melis, Guadalupe; Calle Rosingana, M. Luz; Malats i Riera, Núria (2007-12-10)
      External research report
      Open Access
      Competing risks data usually arises in studies in which the failure of an individual may be classified into one of k (k > 1) mutually exclusive causes of failure. When competing risks are present, classical survival analysis ...
    • Covid-19: la malinterpretación de los datos de la pandemia daña la confianza del público 

      Saez Zafra, Marc; Figueiras Guzmán, Adolfo; Alustiza, Ainhoa; Fernández Martínez, Daniel; Cobo Valeri, Erik; Gómez Melis, Guadalupe; González Alastrué, José Antonio; Fonseca Casas, Pau; Cortés García, Claudio Ulises (2020-11-04)
      Article
      Open Access
    • Decision tool and Sample Size Calculator for composite endpoints 

      Bofill Roig, Marta; Cortés Martínez, Jordi; Gómez Melis, Guadalupe (2020-01-10)
      Article
      Open Access
      This article considers the combination of two binary or two time-to-event endpoints to form the primary composite endpoint for leading a trial. • It discusses the relative efficiency of choosing a composite endpoint over ...
    • Definition of the viral targets of protective HIV-1-specific T cell responses 

      Pérez-Alvarez, Susana; Mothe, Beatriz; Llano, Anuska; Ibarrondo, Javier; Daniels, Marcus; Miranda, Cristina; Zamarreño, Jennifer; Bach, Vanessa; Zuniga, Rosario; Brander, C.; Sanchez, Jorge; Brumme, Chanson J.; Sánchez-Merino, Victor; Yang, Otto O.; Hildebrand, William H.; Szinger, James J.; Farfan, Marilu; Rolland, Morgane; Martínez-Picado, Javier; Puertas, Maria C.; Berger, Chistoph T.; Brumme, Zabrina L.; Korber, Bette T.; Gatell, Jose M.; Clotet, Bonaventura; Goulder, Philip J.; Walker, Bruce D.; Mullins, James I.; Gómez Melis, Guadalupe; Heckerman, David; Allen, Todd M. (2011-12-07)
      Article
      Open Access
      Background: The efficacy of the CTL component of a future HIV-1 vaccine will depend on the induction of responses with the most potent antiviral activity and broad HLA class I restriction. However, current HIV vaccine ...
    • Effect of changing the copular when choosing the primary endpoint in a Randomized Clinical Trial 

      Plana Ripoll, Oleguer; Gómez Melis, Guadalupe (2013)
      Conference report
      Open Access