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Now showing items 1-20 of 59

    • A new approach for sizing trials with composite binary endpoints using anticipated marginal values and accounting for the correlation between components 

      Bofill Roig, Marta; Gómez Melis, Guadalupe (2019-05-20)
      Article
      Open Access
      Composite binary endpoints are increasingly used as primary endpoints in clinical trials. When designing a trial, it is crucial to determine the appropriate sample size for testing the statistical differences between ...

    • A shared-parameter joint model for prostate cancer risk and psa longitudinal profiles 

      Serrat Piè, Carles; Rué, Montserrat; Perpiñán Fabuel, Hèctor; Forte, Anabel; Armero, Carmen; Piulachs, Xavier; Páez, Álvaro; Gómez Melis, Guadalupe (Fundación Mapfre, 2015)
      Conference report
      Open Access
      The paper describes the use of frequentist and Bayesian shared-parameter joint models of longitudinal measurements of prostate specific antigen (PSA) and the risk of prostate cancer (PCa). The motivating dataset corresponds ...

    • Advanced Statistical Inference 

      Gómez Melis, Guadalupe; Sánchez Pla, Àlex (Universitat Politècnica de Catalunya, 2017-01-11)
      Exam
      Restricted access to the UPC academic community

    • ANÀLISI DE LA SUPERVIVÈNCIA 

      Gómez Melis, Guadalupe (Universitat Politècnica de Catalunya, 2011-01-10)
      Exam
      Restricted access to the UPC academic community

    • ANÀLISI DE LA SUPERVIVÈNCIA 

      Gómez Melis, Guadalupe (Universitat Politècnica de Catalunya, 2012-01-11)
      Exam
      Restricted access to the UPC academic community

    • ANÀLISI DE TEMPS DE VIDA 

      Gómez Melis, Guadalupe (Universitat Politècnica de Catalunya, 2016-01-12)
      Exam
      Restricted access to the UPC academic community

    • ANÀLISI DE TEMPS DE VIDA 

      Gómez Melis, Guadalupe (Universitat Politècnica de Catalunya, 2016-01-12)
      Exam
      Restricted access to the UPC academic community

    • Bayesian joint ordinal and survival modeling for breast cancer risk assessment 

      Armero, Carmen; Forné, Carles; Rué, Montserrat; Forte Deltell, Anabel; Perpiñán Fabuel, Hèctor; Gómez Melis, Guadalupe; Bare Mañas, Maris (2016-12-10)
      Article
      Open Access
      We propose a joint model to analyze the structure and intensity of the association between longitudinal measurements of an ordinal marker and time to a relevant event. The longitudinal process is defined in terms of a ...

    • Biometría: Estudios de supervivencia con datos no observados. Dificultades inherentes al enfoque paramétrico 

      Gómez Melis, Guadalupe; Serrat Piè, Carles (Institut d'Estadística de Catalunya, 1999)
      Article
      Open Access
      A partir de una muestra de datos de supervivencia que contiene valores no observados en las covariantes de interés, presentamos una metodología que permite extraer toda la información contenida en covariantes completamente ...

    • BioStatNet: an interdisciplinary biostatistics network 

      Bayarri García, María Jesús; Cadarso Suárez, Carmen; Durbán Reguera, María Luz; Gómez Melis, Guadalupe; López Fidalgo, Jesús; Martín Andrés, Antonio; Nuñez Antón, Vicente; Puig Casado, Pere (Sociedad de Estadística e Investigación Operativa (SEIO), 2012-06)
      Article
      Open Access
      Biostatistics has become a major scientific component of biomedical research with a strong interdisciplinary basis. This endeavour is essentially interdisciplinary, therefore, training of future biostatisticians must ...

    • Clinical trial designs using CompARE. An on-line exploratory tool for investigators 

      Gómez Mateu, Moisés; Gómez Melis, Guadalupe (2017-03)
      External research report
      Open Access
      Conclusions from randomized clinical trials (RCT) rely primarily on the primary endpoint (PE) chosen at the design stage of the study. There should generally be only one PE which should be able to provide the most clinically ...

    • Competing risks methods 

      Porta Bleda, Núria; Gómez Melis, Guadalupe; Calle Rosingana, M. Luz; Malats i Riera, Núria (2007-12-10)
      External research report
      Open Access
      Competing risks data usually arises in studies in which the failure of an individual may be classified into one of k (k > 1) mutually exclusive causes of failure. When competing risks are present, classical survival analysis ...

    • Covid-19: la malinterpretación de los datos de la pandemia daña la confianza del público 

      Saez Zafra, Marc; Figueiras Guzmán, Adolfo; Alustiza, Ainhoa; Fernández Martínez, Daniel; Cobo Valeri, Erik; Gómez Melis, Guadalupe; González Alastrué, José Antonio; Fonseca Casas, Pau; Cortés García, Claudio Ulises (2020-11-04)
      Article
      Open Access

    • Decision tool and Sample Size Calculator for composite endpoints 

      Bofill Roig, Marta; Cortés Martínez, Jordi; Gómez Melis, Guadalupe (2020-01-10)
      Article
      Open Access
      This article considers the combination of two binary or two time-to-event endpoints to form the primary composite endpoint for leading a trial. • It discusses the relative efficiency of choosing a composite endpoint over ...

    • Definition of the viral targets of protective HIV-1-specific T cell responses 

      Pérez-Alvarez, Susana; Mothe, Beatriz; Llano, Anuska; Ibarrondo, Javier; Daniels, Marcus; Miranda, Cristina; Zamarreño, Jennifer; Bach, Vanessa; Zuniga, Rosario; Brander, C.; Sanchez, Jorge; Brumme, Chanson J.; Sánchez-Merino, Victor; Yang, Otto O.; Hildebrand, William H.; Szinger, James J.; Farfan, Marilu; Rolland, Morgane; Martínez-Picado, Javier; Puertas, Maria C.; Berger, Chistoph T.; Brumme, Zabrina L.; Korber, Bette T.; Gatell, Jose M.; Clotet, Bonaventura; Goulder, Philip J.; Walker, Bruce D.; Mullins, James I.; Gómez Melis, Guadalupe; Heckerman, David; Allen, Todd M. (2011-12-07)
      Article
      Open Access
      Background: The efficacy of the CTL component of a future HIV-1 vaccine will depend on the induction of responses with the most potent antiviral activity and broad HLA class I restriction. However, current HIV vaccine ...

    • Effect of changing the copular when choosing the primary endpoint in a Randomized Clinical Trial 

      Plana Ripoll, Oleguer; Gómez Melis, Guadalupe (2013)
      Conference report
      Open Access

    • Estudio de los factores asociados a la pérdida de densidad mineral ósea en pacientes infectados con VIH 

      Figueras-Balsells, M.; Pérez Álvarez, Nuria; Negredo, Eugènia; Estany, C.; Bonjoch, A.; Gómez Melis, Guadalupe (2009)
      Conference report
      Open Access

    • Extension of the asymptotic relative efficiency method to select the primary endpoint in a randomized clinical trial 

      Plana-Ripoll, Oleguer; Gómez Melis, Guadalupe (2014-10-13)
      External research report
      Open Access
      We extend the ARE method proposed in Gómez and Lagakos (2013) devised to decide which primary endpoint to choose when comparing two treatments in a randomized clinical trial. The ARE method is based on the Asymptotic ...

    • Extensions and applications of CompARE : web platform to select the primary endpoint in a randomized clinical trial 

      Gómez Mateu, Moisés; Gómez Melis, Guadalupe (Fundación Mapfre, 2015)
      Conference report
      Open Access
      We present CompARE, a web platform that computes how more efficient is to use a composite endpoint instead of one of its components. CompARE is based on the Asymptotic Relative Efficiency (ARE) method develop by Gómez and ...

    • FARMS: a new algorithm for variable selection 

      Pérez Álvarez, Susana; Gómez Melis, Guadalupe; Brander, Christian (2015-01-01)
      Article
      Open Access
      Large datasets including an extensive number of covariates are generated these days in many different situations, for instance, in detailed genetic studies of outbreed human populations or in complex analyses of immune ...