Browsing by Author "Gómez Melis, Guadalupe"Més informacióMés informació

Now showing items 1-20 of 44

  • A shared-parameter joint model for prostate cancer risk and psa longitudinal profiles 

    Serrat Piè, Carles; Rué, Montserrat; Perpiñán Fabuel, Hèctor; Forte, Anabel; Armero, Carmen; Piulachs, Xavier; Páez, Álvaro; Gómez Melis, Guadalupe (Fundación Mapfre, 2015)
    Conference report
    Open Access
    The paper describes the use of frequentist and Bayesian shared-parameter joint models of longitudinal measurements of prostate specific antigen (PSA) and the risk of prostate cancer (PCa). The motivating dataset corresponds ...

  • Bayesian joint ordinal and survival modeling for breast cancer risk assessment 

    Armero, Carmen; Forné, Carles; Rué, Montserrat; Forte Deltell, Anabel; Perpiñán Fabuel, Hèctor; Gómez Melis, Guadalupe; Bare Mañas, Maris (2016-12-10)
    Article
    Open Access
    We propose a joint model to analyze the structure and intensity of the association between longitudinal measurements of an ordinal marker and time to a relevant event. The longitudinal process is defined in terms of a ...

  • Biometría: Estudios de supervivencia con datos no observados. Dificultades inherentes al enfoque paramétrico 

    Gómez Melis, Guadalupe; Serrat Piè, Carles (Institut d'Estadística de Catalunya, 1999)
    Article
    Open Access
    A partir de una muestra de datos de supervivencia que contiene valores no observados en las covariantes de interés, presentamos una metodología que permite extraer toda la información contenida en covariantes completamente ...

  • BioStatNet: an interdisciplinary biostatistics network 

    Bayarri García, María Jesús; Cadarso Suárez, Carmen; Durbán Reguera, María Luz; Gómez Melis, Guadalupe; López Fidalgo, Jesús; Martín Andrés, Antonio; Nuñez Antón, Vicente; Puig Casado, Pere (Sociedad de Estadística e Investigación Operativa (SEIO), 2012-06)
    Article
    Open Access
    Biostatistics has become a major scientific component of biomedical research with a strong interdisciplinary basis. This endeavour is essentially interdisciplinary, therefore, training of future biostatisticians must ...

  • Clinical trial designs using CompARE. An on-line exploratory tool for investigators 

    Gómez Mateu, Moisés; Gómez Melis, Guadalupe (2017-03)
    External research report
    Open Access
    Conclusions from randomized clinical trials (RCT) rely primarily on the primary endpoint (PE) chosen at the design stage of the study. There should generally be only one PE which should be able to provide the most clinically ...

  • Competing risks methods 

    Porta Bleda, Núria; Gómez Melis, Guadalupe; Calle Rosingana, M. Luz; Malats i Riera, Núria (2007-12-10)
    External research report
    Open Access
    Competing risks data usually arises in studies in which the failure of an individual may be classified into one of k (k > 1) mutually exclusive causes of failure. When competing risks are present, classical survival analysis ...

  • Definition of the viral targets of protective HIV-1-specific T cell responses 

    Pérez-Alvarez, Susana; Mothe, Beatriz; Llano, Anuska; Ibarrondo, Javier; Daniels, Marcus; Miranda, Cristina; Zamarreño, Jennifer; Bach, Vanessa; Zuniga, Rosario; Brander, C.; Sanchez, Jorge; Brumme, Chanson J.; Sánchez-Merino, Victor; Yang, Otto O.; Hildebrand, William H.; Szinger, James J.; Farfan, Marilu; Rolland, Morgane; Martínez-Picado, Javier; Puertas, Maria C.; Berger, Chistoph T.; Brumme, Zabrina L.; Korber, Bette T.; Gatell, Jose M.; Clotet, Bonaventura; Goulder, Philip J.; Walker, Bruce D.; Mullins, James I.; Gómez Melis, Guadalupe; Heckerman, David; Allen, Todd M. (2011-12-07)
    Article
    Open Access
    Background: The efficacy of the CTL component of a future HIV-1 vaccine will depend on the induction of responses with the most potent antiviral activity and broad HLA class I restriction. However, current HIV vaccine ...

  • Effect of changing the copular when choosing the primary endpoint in a Randomized Clinical Trial 

    Plana Ripoll, Oleguer; Gómez Melis, Guadalupe (2013)
    Conference report
    Open Access

  • Estudio de los factores asociados a la pérdida de densidad mineral ósea en pacientes infectados con VIH 

    Figueras-Balsells, M.; Pérez Álvarez, Nuria; Negredo, Eugènia; Estany, C.; Bonjoch, A.; Gómez Melis, Guadalupe (2009)
    Conference report
    Open Access

  • Extension of the asymptotic relative efficiency method to select the primary endpoint in a randomized clinical trial 

    Plana-Ripoll, Oleguer; Gómez Melis, Guadalupe (2014-10-13)
    External research report
    Open Access
    We extend the ARE method proposed in Gómez and Lagakos (2013) devised to decide which primary endpoint to choose when comparing two treatments in a randomized clinical trial. The ARE method is based on the Asymptotic ...

  • Extensions and applications of CompARE : web platform to select the primary endpoint in a randomized clinical trial 

    Gómez Mateu, Moisés; Gómez Melis, Guadalupe (Fundación Mapfre, 2015)
    Conference report
    Open Access
    We present CompARE, a web platform that computes how more efficient is to use a composite endpoint instead of one of its components. CompARE is based on the Asymptotic Relative Efficiency (ARE) method develop by Gómez and ...

  • FARMS: a new algorithm for variable selection 

    Pérez Álvarez, Susana; Gómez Melis, Guadalupe; Brander, Christian (2015-01-01)
    Article
    Open Access
    Large datasets including an extensive number of covariates are generated these days in many different situations, for instance, in detailed genetic studies of outbreed human populations or in complex analyses of immune ...

  • Flexible geoadditive survival analysis of non-Hodgkin lymphoma in Peru 

    Flores, Claudio; Rodríguez-Girondo, Mar; Cadarso Suárez, Carmen; Kneib, Thomas; Gómez Melis, Guadalupe; Casanova, Lluis (2012-06)
    Article
    Open Access
    Knowledge of prognostic factors is an important task for the clinical management of Non Hodgkin Lymphoma (NHL). In this work, we study the variables affecting survival of NHL in Peru by means of geoadditive Cox-type ...

  • Flexible geoadditive survival analysis of non-Hodgkin lymphoma in Peru 

    Flores, Carlos; Rodríguez-Girondo, Mar; Cadarso-Suárez, Carmen; Kneib, Thomas; Gómez Melis, Guadalupe; Casanova, Luís (Institut d'Estadística de Catalunya, 2012)
    Article
    Open Access
    Knowledge of prognostic factors is an important task for the clinical management of Non Hodgkin Lymphoma (NHL). In this work, we study the variables affecting survival of NHL in Peru by means of geoadditive Cox-type ...

  • Frequentist and Bayesian approaches for a joint model for prostate cancer risk and longitudinal prostate-specific antigen data 

    Serrat Piè, Carles; Rué, Montserrat; Armero, Carmen; Piulachs, Xavier; Perpiñán Fabuel, Hèctor; Forte, Anabel; Páez, Álvaro; Gómez Melis, Guadalupe (Taylor & Francis, 2015-06-03)
    Article
    Open Access
    The paper describes the use of frequentist and Bayesian shared-parameter joint models of longitudinal measurements of prostate-specific antigen (PSA) and the risk of prostate cancer (PCa). The motivating dataset corresponds ...

  • Heavy right censoring: when is too heavy? 

    López-Segovia, Lucas; Gómez Melis, Guadalupe; Espinal Berenguer, Anna (2009)
    Conference report
    Restricted access - publisher's policy
    The main purpose of this work is to study the effect that a large percentage of right censoring has on the estimation of the regression parameters under a proportional hazards model. To accomplish this we conduct a simulation ...

  • High risk and probability of progression to osteoporosis at 10 years in HIV-infected individuals: the role of PIs 

    Negredo Puigmal, Eugènia; Langohr, Klaus; Bonjoch Badia, Anna; Pérez Álvarez, Nuria; Estany Quera, Carla; Puig, Jordi; Echevarría, Patricia; Clotet Sala, Bonaventura; Gómez Melis, Guadalupe (2018-09-01)
    Article
    Restricted access - publisher's policy

  • Identification of interleukin-27 (IL-27)/IL-27 receptor subunit alpha as a critical immune axis for in vivo hiv control 

    Ruiz-Riol, M.; Berdnik, D.; Llano, A.; Mothe, Beatriz; Gálvez, C.; Pérez Alvarez, Susana; Oriol Tordera, B.; Olvera Van der Stoep, Alex; Silva Arrieta, S.; Meulbroek, M.; Salvat Pujol, Francesc; Coll, J.; Martínez Picado, Javier; Ganoza, Carmela; Sánchez, J.; Gómez Melis, Guadalupe; Coray, Wyss; Brander, Christian (2017-08-01)
    Article
    Open Access
    Intact and broad immune cell effector functions and specific individual cytokines have been linked to HIV disease outcome, but their relative contribution to HIV control remains unclear. We asked whether the proteome of ...

  • Interruptions of antiretroviral therapy in human immunodeficiency virus infection: are they detrimental to neurocognitive functioning? 

    Clotet, Bonaventura; Garolera, Maite; Muñoz Moreno, Jose A.; Fumaz, Carmina R.; Prats, Anna; Ferrer, Maria J.; Negredo, Eugènia; Pérez Álvarez, Nuria; Molto, Jose; Gómez Melis, Guadalupe (2010-06)
    Article
    Restricted access - publisher's policy
    Because interruptions of antiretroviral treatment may entail clinical risks for human immunodeficiency virus (HIV)-infected individuals, we investigated their impact on neurocognitive functioning. Cross-sectional study ...

  • Joint modelling of two sequential times to event with longitudinal information 

    Huertas, Jaime-Abel; Gómez Melis, Guadalupe; Serrat Piè, Carles (2011)
    Conference lecture
    Open Access
    In survival analysis, the lifetimes may be observed in some speci¯ed order, where the time to event Tk, cannot be observed until T1; :::; Tk¡1 have been observed. The present work proposes a joint model of two sequential ...