Now showing items 1-20 of 24

    • Bacteria-responsive multilayer coatings comprising polycationic nanospheres for bacteria biofilm prevention on urinary catheters 

      Francesko, Antonio; Macedo Fernandes, Margarida Maria; Ivanova, Kristina Dimitrova; Tzanov, Tzanko (2016-01-21)
      Article
      Open Access
      This work reports on the development of infection-preventive coatings on silicone urinary catheters that contain in their structure and release on demand antibacterial polycationic nanospheres. Polycationic aminocellulose ...
    • Bottom-up layer-by-layer assembling of antibacterial freestanding nanobiocomposite films 

      Francesko, Antonio; Ivanova, Kristina Dimitrova; Hoyo Pérez, Javier; Pérez-Rafael, Silvia; Petkova, Petya; Fernandes Macedo, Margarida Maria; Heinze, Thomas; Mendoza Gómez, Ernesto; Tzanov, Tzanko (2018-07-27)
      Article
      Open Access
      In this study, freestanding nanobiocomposite films were obtained by the sequential deposition of biopolymer-capped silver nanoparticles (AgNPs) and hyaluronic acid (HA). At first, dispersions ofAgNPs decorated with chitosan ...
    • Effect of thiol-functionalisation on chitosan antibacterial activity: interaction with a bacterial membrane model 

      Macedo Fernandes, Margarida Maria; Francesko, Antonio; Torrent Burgués, Juan; Tzanov, Tzanko (2013-01-12)
      Article
      Restricted access - publisher's policy
      The antibacterial activity of chitosan modified with the thiol-containing 2-iminothiolane HCl (TC-IMI) and N-acetyl- L -cysteine (TC-NAC) was studied by Langmuir film balance technique using a dipalmitoylphos- phatidylglycerol ...
    • Enzymatic functionalization of cork surface with antimicrobial hybrid biopolymer/silver nanoparticles 

      Francesko, Antonio; Blandon, Lucas; Vázquez, Mario; Petkova Petkova, Petya Stoyanova; Morató Farreras, Jordi; Pfeifer, Annett; Heinze, Thomas; Mendoza Gómez, Ernesto; Tzanov, Tzanko (2015-05-13)
      Article
      Open Access
      Laccase-assisted assembling of hybrid biopolymer-silver nanoparticles and cork matrices into an antimicrobial material with potential for water remediation is herein described. Amino-functional biopolymers were first used ...
    • Enzyme-assisted formation of hybrid biopolymer hydrogels incorporating active phenolic nanospheres 

      Petkova Petkova, Petya Stoyanova; Francesko, Antonio; Tzanov, Tzanko (2015-02-01)
      Article
      Restricted access - publisher's policy
      This work is about the synthesis of hybrid nanocomposite hydrogels comprising a thiolated chitosan platform that incorporates epigallocatechin gallate nanospheres as active polyphenolic agents for wound healing applications. ...
    • Escherichia coli and pseudomonas aeruginosa eradication by nano-penicillin G 

      Macedo Fernandes, Margarida Maria; Ivanova, Kristina Dimitrova; Francesko, Antonio; Rivera, Diana; Torrent Burgués, Juan; Mendoza Gómez, Ernesto; Tzanov, Tzanko (2016-06-09)
      Article
      Open Access
      The transformation of penicillin G into nano/micro-sized spheres (nanopenicillin) using sonochemical technology was explored as a novel tool for the eradication of Gram-negative bacteria and their biofilms. Known by its ...
    • Functional biopolymer-based matrices for modulation of chronic wound enzyme activities 

      Francesko, Antonio; Soares da Costa, Diana; Reis, Rui L.; Pashkuleva, Iva; Tzanov, Tzanko (2012-10-13)
      Article
      Restricted access - publisher's policy
      Collagen, collagen/hyaluronic acid (HA) and collagen/HA/chitosan (CS) sponges loaded with epigallocatechin gallate (EGCG), catechin (CAT) and gallic acid (GA) were developed and evaluated as active chronic wound dressings. ...
    • GAGs-thiolated chitosan assemblies for chronic wounds treatment: control of enzyme activity and cell attachment 

      Francesko, Antonio; Soares da Costa, Diana; Lisboa, Patricia; Reis, Rui L.; Tzanov, Tzanko; Iva Hristova, Pashkuleva (2012-04-20)
      Article
      Restricted access - publisher's policy
      Multilayered polyelectrolyte coatings comprising thiolated chitosan (TC) and glycosaminoglycans (GAGs), chondroitin sulphate and hyaluronic acid, were built using a layer-by-layer approach. The surface activity of these ...
    • Hybrid chitosan-silver nanoparticles enzymatically-embedded on cork filter material for water disinfection 

      Garcia Peña, Lina Vanesa; Petkova, Petya; Margalef-Marti, Rosanna; Vives, Marc; Aguilar, Lorena; Gallegos, Angel; Francesko, Antonio; Perelshtein, Ilana; Gedanken, Aharon; Mendoza Gómez, Ernesto; Casas-Zapata, Juan Carlos; Morató Farreras, Jordi; Tzanov, Tzanko (2017-04-05)
      Article
      Restricted access - publisher's policy
      Microbial contamination remains a major challenge in supply of drinking water in developing regions, despite the continuous advances being made in water purification processes. The spread and transmission of pathogens due ...
    • Hydrogel dressings for advanced wound management 

      Francesko, Antonio; Petkova, Petya; Tzanov, Tzanko (2018-12)
      Article
      Open Access
      Composed in a large extent of water and due to their non-adhesiveness, hydrogels found their way to the wound dressing market as materials that provide a moisture environment for healing while being comfortable to the ...
    • Immobilization of antimicrobial core-shell nanospheres onto silicone for prevention of Escherichia coli biofilm formation 

      Macedo Fernandes, Margarida Maria; Ivanova, Kristina Dimitrova; Mendoza Gómez, Ernesto; Tzanov, Tzanko; Francesko, Antonio (2016-09-16)
      Article
      Open Access
      Escherichia coli (E. coli) strains are among the most frequently isolated microorganisms in urinary tract infections able to colonize the surface of urinary catheters and form biofilms. These biofilms are highly resistant ...
    • Inhibition of deleterious chronic wound enzymes with plant polyphenols 

      Díaz González, María; Rocasalbas Lozano, Guillem; Francesko, Antonio; Touriño Eirín, Sonia; Torres, Josep Lluis; Tzanov, Tzanko (2012-01-18)
      Article
      Restricted access - publisher's policy
      The chronic wound environment is characterized by high concentrations of reactive oxygen species (ROS) and elevated levels of myeloperoxidase (MPO) and collagenases, together impairing the healing process. Therefore, the ...
    • Laccase-assisted formation of bioactive chitosan/gelatin hydrogel stabilized with plant polyphenols 

      Rocasalbas Lozano, Guillem; Francesko, Antonio; Touriño Eirín, Sonia; Fernández Francos, Xavier; Guebitz, Georg M.; Tzanov, Tzanko (2012-11-02)
      Article
      Restricted access - publisher's policy
      Laccase-assisted simultaneous cross-linking and functionalization of chitosan/gelatin blends with phenolic compounds from Hamamelis virginiana was investigated for the development of bioactive hydrogel dressings. The ...
    • Multifuncional biopolymer-bases materials for modulatig the activites of chromic wound enzymes 

      Francesko, Antonio (Universitat Politècnica de Catalunya, 2012-11-29)
      Doctoral thesis
      Open Access
      This thesis focuses on the development of active multifunctional dressing materials and nanoparticle formulations with suitable exploitation characteristics for chronic wounds treatment. Chronic wounds a growing clinical ...
    • Nanotransformation of vancomycin overcomes the intrinsic resistance of Gram-negative bacteria 

      Ivanova, Kristina Dimitrova; Hoyo Pérez, Javier; Francesko, Antonio; Tzanov, Tzanko; Fernandes, Margarida M.; Pérez Rafael, Silvia (2017-04-10)
      Article
      Open Access
      The increased emergence of antibiotic-resistant bacteria is a growing public health concern, and although new drugs are constantly being sought, the pace of development is slow compared with the evolution and spread of ...
    • One-step sonochemical preparation of redox-responsive nanocapsules for glutathione mediated RNA release 

      Francesko, Antonio; Macedo Fernandes, Margarida Maria; Tzanov, Tzanko; Perelshtein, Illana; Benisvy Aharonovich, Lena; Gedanken, Aharon (Royal Society of Chemistry, 2014-07-09)
      Article
      Restricted access - publisher's policy
      Efficient RNA delivery to targeted cells requires the use of stable interactive carriers that provide RNA protection during the extracellular transit and trigger release once internalised. One strategy to avoid the premature ...
    • Quorum-quenching and matrix-degrading enzymes in multilayer coatings synergistically prevent bacterial biofilm formation on urinary catheters 

      Ivanova, Kristina Dimitrova; Macedo Fernandes, Margarida Maria; Francesko, Antonio; Mendoza Gómez, Ernesto; Tzanov, Tzanko (2015-12-02)
      Article
      Open Access
      Bacteria often colonize in-dwelling medical devices and grow as complex biofilm communities of cells embedded in a self-produced extracellular polymeric matrix, which increases their resistance to antibiotics and the host ...
    • Sensor materials for the detection of human neutrophil elastase and cathepsin G activity in wound ¿uid 

      Wehrschuetz-Sigl, Eva; Guebitz, Georg M.; Van der Palen, Job; Hasmann, Andrea; Gewessler, Ulrike; Hulla, Elisabet; Schneider, Konstantin P.; Binder, Barbara; Francesko, Antonio; Tzanov, Tzanko; Schintler, Michael (2011-04-13)
      Article
      Restricted access - publisher's policy
      Human neutrophil elastase (HNE) and cathepsin G (CatG) are involved in the pathogenesis of a number of inflammatory disorders. These serine proteinases are released by neutrophils and monocytes in case of infection. Wound ...
    • Simultaneous sonochemical-enzymatic coating of medical textiles with antibacterial ZnO nanoparticles 

      Petkova Petkova, Petya Stoyanova; Francesko, Antonio; Perelshtein, Ilana; Gedanken, Aharon; Tzanov, Tzanko (2016-03-01)
      Article
      Open Access
      The antimicrobial finishing is a must for production of medical textiles, aiming at reducing the bioburden in clinical wards and consequently decreasing the risk of hospital-acquired infections. This work reports for the ...
    • Size and aging effects on antimicrobial efficiency of silver nanoparticles coated on polyamide fabrics activated by atmospheric DBD plasma 

      Zille, Andrea; Macedo Fernandes, Margarida Maria; Francesko, Antonio; Tzanov, Tzanko; Fernandes Sousa, Marta; Oliveira, Fernando R.; Almeida Torres, Luís; Amorim Lago, Teresa; Carneiro, Noémia; Esteves, Maria Fernanda; Souto, António Pedro (2015-06-09)
      Article
      Open Access
      This work studies the surface characteristics, antimicrobial activity, and aging effect of plasma-pretreated polyamide 6,6 (PA66) fabrics coated with silver nanoparticles (AgNPs), aiming to identify the optimum size of ...