Browsing by Author "Pérez González, Juan Jesús"
Now showing items 1-20 of 59
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6a Jornada d'Igualtat de la UPC. Una mirada al present
(2019-02-06)
Audiovisual
Open Access -
A computational study of Neuromedin B
(2011-09-15)
Article
Restricted access - publisher's policyA methodological study has been undertaken to assess the conformational profile of Neuromedin B (NMB) using classical molecular dynamics simulations (MD) and replica exchange molecular dynamics (REMD) simulations under ... -
A step forward toward selective activation/inhibition of bak, a pro-apoptotic member of the Bcl-2 protein family: discovery of new prospective allosteric sites using molecular dynamics
(American Chemical Society, 2023-01-01)
Article
Open AccessBak is a pro-apoptotic protein and a member of the Bcl-2 family that plays a key role in apoptosis, a programmed cell death mechanism of multicellular organisms. Its activation under death stimuli triggers the permeabilization ... -
Action potential propagation: ion current or intramembrane electric field?
(2018-01-22)
Article
Open AccessThe established action potential propagation mechanisms do not satisfactorily explain propagation on myelinated axons given the current knowledge of biological channels and membranes. The flow across ion channels presents ... -
Adsorció de l'herbicida Paraquat en Alginat de Calci
(Centre per a la Sostenibilitat, 2009-07-09)
Conference lecture / Conference report
Open AccessLa sostenibilitat de l’ús de l’aigua esta lligada de forma fonamental al seu ús en l’agricultura. L’activitat agrària afecta directament la qualitat de les aigües. Els residus de fertilitzants i de productes fitosanitaris, ... -
Adsorció de l'herbicida paraquat en alginat de calci
(2009)
Conference report
Open AccessLa sostenibilitat de l’ús de l’aigua esta lligada de forma fonamental al seu ús en l’agricultura. L’activitat agrària afecta directament la qualitat de les aigües. Els residus de fertilitzants i de productes fitosanitaris, ... -
Amygdalin analogues inhibit INF-gamma signalling reducing inflammatory response in human keratinocytes (HaCat)
(2013-12-02)
Article
Restricted access - publisher's policyPeptide T (PT), an octapeptide fragment located in the V2 region of the HIV-1 gp120- coating protein, appears to be bene fi cial in the treatment of psoriasis. Our previous investigations suggest that keratinocytes ... -
Anti-inflammatory effect of amygdalin analogs following topical administration on the TPA-induced irritant contact dermatitis model in mice
(2021-01-26)
Article
Open AccessAmygdalin is a cyanogenic glycoside found in seeds of apricots, peaches, almonds, and other rosaceous stone fruits. A few years ago, amygdalin was identified as a peptidomimetic of peptide T, a compound that had been ... -
Assessment of the bound conformation of bombesin to the BB1 and BB2 receptors
(Elsevier, 2024-01-01)
Article
Restricted access - publisher's policyBombesin is an endogenous peptide involved in a wide spectrum of physiological activities ranging from satiety, control of circadian rhythm and thermoregulation in the central nervous system, to stimulation of gastrointestinal ... -
Assessment of the conformational profile of bombesin by computational methods
(2020-07-20)
Article
Open AccessIn the present work, the results of a computational study aimed at assessing the conformational profile of bombesin are reported. The conformational space of the peptide was sampled by means of a 4 µs accelerated molecular ... -
Assessment of the sampling performance of multiple-copy dynamics versus a unique trajectory
(2016-10-01)
Article
Restricted access - publisher's policyThe goal of the present study is to ascertain the differential performance of a long molecular dynamics trajectory versus several shorter ones starting from different points in the phase space and covering the same sampling ... -
Blockade of the interaction of calcineurin with foxo in astrocytes protects against Aß-induced neuronal death
(2016-06-23)
Article
Open AccessAstrocytes actively participate in neuro-inflammatory processes associated to Alzheimer’s disease (AD), and other brain pathologies. We recently showed that an astrocyte-specific intracellular signaling pathway involving ... -
Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-beta-Induced Neuronal Death
(2016-01-01)
Article
Open AccessAstrocytes actively participate in neuro-inflammatory processes associated to Alzheimer's disease (AD), and other brain pathologies. We recently showed that an astrocyte-specific intracellular signaling pathway involving ... -
Computational investigation of the conformational profile of the four stereomers of Ac-L-Pro-c(3)Phe-NHMe (c(3)Phe= 2,3-methanophenylalanine)
(2009)
Article
Restricted access - publisher's policyThe present report regards a computational study aimed at assessing the conformational profile of the four stereoisomers of the peptide Ace-Pro-c3Phe-NMe, previously reported to exhibit b-turn structures in dichloromethane ... -
Computational study of substrates and mediators features of lacasses
(2013-06-10)
Article
Restricted access - publisher's policyLaccases are enzymes of the family multicopper oxidases, being widely used for biotechnological applications (Canas & Camarero, 2010). The enzymes’ catalytic cycle consists of the oxidation of the substrate with the ... -
Computational study of substrates and mediators features of lacasses
(Campus de Terrassa de la UPC, 2013-06-13)
Conference report
Open AccessLaccases are enzymes of the family of the multicopper oxidases, being widely used for biotechnological applications. The enzyme catalytic cycle consists in the oxidation of the substrate with the concomitant reduction of ... -
Computational study of the free energy landscape of the miniprotein CLN025 in explicit and implicit solvent
(2010-02-17)
Article
Restricted access - publisher's policyThe prediction capabilities of atomistic simulations of peptides are hampered by different difficulties, including the reliability of force fields, the treatment of the solvent or the adequate sampling of the conformational ... -
Conformational diversity in contryphans from conus venom: Cis-trans isomerisation and aromatic/proline interactions in the 23-membered ring of a 7-residue peptide disulfide loop
(2013-11-05)
Article
Restricted access - publisher's policyConformational diversity or “shapeshifting” in cyclic peptide natu- ral products can, in principle, confer a single molecular entity with the proper- ty of binding to multiple receptors. Conformational equilibria have ... -
Conformational ensembles of neuromedin C reveal a progressive coil-helix transition within a binding-induced folding mechanism
(2015-01-01)
Article
Open AccessNeuromedin C (NMC) is a peptide that regulates various processes in the central nervous system and gastrointestinal tract through its interaction with the bombesin receptor subtype-2 (BB2R). Hence, BB2R antagonists hold ... -
Dades de recerca
(Universitat Politècnica de Catalunya, 2024-05-30)
Conference lecture
Open Access
