Now showing items 1-9 of 9

    • Crystal structure of a complex of DNA with one AT-hook of HMGA1 

      Fonfria Subirós, Elsa; Acosta Reyes, Francisco Javier; Saperas Plana, Núria; Pous, Joan; Subirana Torrent, Juan A.; Campos López, Josefina de Lourdes (2012-05-16)
      Article
      Open Access
      We present here for the first time the crystal structure of an AT-hook domain. We show the structure of an AT-hook of the ubiquitous nuclear protein HMGA1, combined with the oligonucleotide d(CGAATTAATTCG)2, which has two ...
    • Estudios Estructurales de Oligonucleótidos Ricos en Adeninas y Timinas 

      Acosta Reyes, Francisco Javier (Universitat Politècnica de Catalunya, 2011-02)
      Master thesis
      Restricted access - author's decision
      En este trabajo se llevan a cabo estudios de diferentes oligonucleótidos de secuencias presentes en zonas no codificantes con alto contenido de adeninas y timinas. Uno de los objetivos principales del proyecto era el ...
    • Functional and structural analysis of AT-specific minor groove binders that disrupt DNA-protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast 

      Millán Elías, Cinthia Raquel; Acosta Reyes, Francisco Javier; Lagartera, Laura; Ebiloma, Godwin U.; Lemgruber, Leandro; Nué Martinez, J. Jonathan; Saperas Plana, Núria; Dardonville, Cristophe; De Koning, Harry Pieter; Campos López, Josefina de Lourdes (2017-08-21)
      Article
      Open Access
      Trypanosoma brucei, the causative agent of sleeping sickness (Human African Trypanosomiasis, HAT), contains a kinetoplast with the mitochondrial DNA (kDNA), comprising of >70% AT base pairs. This has prompted studies of ...
    • In and out of the minor groove: Interaction of an AT-rich DNA with the drug CD27 

      Acosta Reyes, Francisco Javier; Dardonville, Cristophe Y.; De Koning, Harry Pieter; Natto, Manal J.; Subirana, Juan Antonio; Campos López, Josefina de Lourdes (2014-06)
      Article
      Open Access
      The DNA of several pathogens is very rich in AT base pairs. Typical examples include the malaria parasite Plasmodium falciparum and the causative agents of trichomoniasis and trypanosomiases. This fact has prompted studies ...
    • New drugs complexed with AT-rich DNA against neglected diseases 

      Millán, Cinthia; Acosta Reyes, Francisco Javier; Lagartera, Laura; Saperas Plana, Núria; Dardonville, Cristophe; De Koning, Harry Pieter; Campos López, Josefina de Lourdes (2019)
      Conference lecture
      Restricted access - publisher's policy
    • Structural studies of AT-rich DNA 

      Acosta Reyes, Francisco Javier (Universitat Politècnica de Catalunya, 2016-05-26)
      Doctoral thesis
      Open Access
      Non-coding DNA is rich in adenines and thymines. Their unique properties, such as high polymorphism, flexibility, transitional states that lead to DNA hairpin formation and the possibility to adopt either Watson-Crick or ...
    • Structure of the DNA duplex d(ATTAAT)(2) with Hoogsteen hydrogen bonds 

      Acosta Reyes, Francisco Javier; Subirana, Juan Antonio; Campos López, Josefina de Lourdes; Alechaga, Elida (2015-03-17)
      Article
      Open Access
      The traditional Watson-Crick base pairs in DNA may occasionally adopt a Hoogsteen conformation, with a different organization of hydrogen bonds. Previous crystal structures have shown that the Hoogsteen conformation is ...
    • The influence of Ni2+ and other ions on the trigonal structure of DNA 

      Acosta Reyes, Francisco Javier; Pagan, Mireia; Fonfría-Subirós, Elsa; Saperas Plana, Núria; Subirana Torrent, Juan A.; Campos López, Josefina de Lourdes (Wiley, 2021-04-13)
      Article
      Open Access
      We present a new structure of a DNA dodecamer obtained in the presence of Ni2+ ions. The DNA forms Ni-guanine cross-links between neighboring molecules. Our results show that an adequate dosage of Ni2+ may help to form ...
    • Two high-mobility group box domains act together to underwind and kink DNA. 

      Sánchez Giraldo, Raquel; Acosta Reyes, Francisco Javier; Malarkey, Christopher S.; Saperas Plana, Núria; Churchill, Mair E. A.; Campos López, Josefina de Lourdes (2015-07-02)
      Article
      Open Access
      High-mobility group protein 1 (HMGB1) is an essential and ubiquitous DNA architectural factor that influences a myriad of cellular processes. HMGB1 contains two DNA-binding domains, box A and box B, which have little ...