Browsing by Author "Rasaeifar, Bahareh"
Rasaeifar, Bahareh (Universitat Politècnica de Catalunya, 2013-11)
Open AccessThere are still many question open to completely understand the structure-activity relationships of G-protein coupled receptors. Issues like the actual mapping of the binding site of different subtypes, as well as the ...
Rasaeifar, Bahareh; Gómez Gutierrez, Patricia; Pérez González, Juan Jesús (2020-09-21)
Open AccessAngiotensin converting enzyme 2 (ACE2) downregulation is a key negative factor for the severity of lung edema and acute lung failure observed in patients infected with SARS-CoV-2. ACE2 downregulation affects the levels of ...
New insights into the stereochemical requirements of the bombesin BB1 receptor antagonists binding Rasaeifar, Bahareh; Gómez Gutiérrez, Patricia; Pérez González, Juan Jesús (2020-08-17)
Open AccessMembers of the family of bombesinlike peptides exert a wide range of biological activities both at the central nervous system and in peripheral tissues through at least three G-Protein Coupled Receptors: BB1, BB2 and BB3. ...
Structure-function studies of bombesin and bradykinin receptors and their ligands for new therapeutic opportunities Rasaeifar, Bahareh (Universitat Politècnica de Catalunya, 2020-12-10)
Open AccessG-protein coupled receptors represents the largest family of membrane protein in eukaryotes cells with more than 800 members. The reason of their importance lies in their function, being responsible for the primary mechanism ...
Lupala, Cecylia Severin; Rasaeifar, Bahareh; Gómez Gutiérrez, Patricia; Pérez González, Juan Jesús (2017-08-13)
Open AccessDespite GPCRs sharing a common seven helix bundle, analysis of the diverse crystallographic structures available reveal specific features that might be relevant for ligand design. Despite the number of crystallographic ...