Exploració per autor "Rasaeifar, Bahareh"
Ara es mostren els items 1-5 de 5
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Effect of the ligand in the Modeling the 3d structure of the m3 muscarinic receptor
Rasaeifar, Bahareh (Universitat Politècnica de Catalunya, 2013-11)
Projecte Final de Màster Oficial
Accés obertThere are still many question open to completely understand the structure-activity relationships of G-protein coupled receptors. Issues like the actual mapping of the binding site of different subtypes, as well as the ... -
Molecular features of non-selective small molecule antagonists of the Bradykinin receptors
Rasaeifar, Bahareh; Gómez Gutierrez, Patricia; Pérez González, Juan Jesús (2020-09-21)
Article
Accés obertAngiotensin converting enzyme 2 (ACE2) downregulation is a key negative factor for the severity of lung edema and acute lung failure observed in patients infected with SARS-CoV-2. ACE2 downregulation affects the levels of ... -
New insights into the stereochemical requirements of the bombesin BB1 receptor antagonists binding
Rasaeifar, Bahareh; Gómez Gutiérrez, Patricia; Pérez González, Juan Jesús (2020-08-17)
Article
Accés obertMembers of the family of bombesinlike peptides exert a wide range of biological activities both at the central nervous system and in peripheral tissues through at least three G-Protein Coupled Receptors: BB1, BB2 and BB3. ... -
Structure-function studies of bombesin and bradykinin receptors and their ligands for new therapeutic opportunities
Rasaeifar, Bahareh (Universitat Politècnica de Catalunya, 2020-12-10)
Tesi
Accés obertG-protein coupled receptors represents the largest family of membrane protein in eukaryotes cells with more than 800 members. The reason of their importance lies in their function, being responsible for the primary mechanism ... -
Using molecular dynamics for the refinement of atomistic models of GPCRs by homology modeling
Lupala, Cecylia Severin; Rasaeifar, Bahareh; Gómez Gutiérrez, Patricia; Pérez González, Juan Jesús (2017-08-13)
Article
Accés obertDespite GPCRs sharing a common seven helix bundle, analysis of the diverse crystallographic structures available reveal specific features that might be relevant for ligand design. Despite the number of crystallographic ...