Rationale: Ca2+ alternans plays an essential role in cardiac alternans that can lead to ventricular fibrillation, but the mechanism underlying Ca2+ alternans remains undefined. Increasing evidence suggests that Ca2+ ...

Cardiac ryanodine receptor (RyR2) gain-of-function mutations cause catecholaminergic polymorphic ventricular tachycardia, a condition characterized by prominent ventricular ectopy in response to catecholamine stress, which ...

Cardiac ryanodine receptors (RyR2s) are Ca2þ release channels clustering in the sarcoplasmic reticulum membrane. These clusters are believed to be the elementary units of Ca2þ release. The distribution of these Ca2þ release ...

The cardiac Ca2+ release channel (ryanodine receptor, RyR2) plays an essential role in excitation-contraction coupling in cardiac muscle cells. Effective and stable excitation-contraction coupling critically depends not ...

This paper introduces a data-based fault diagnosis system that includes an enhanced characterization of faults during transient stages. First, data under abnormal operating conditions (AOC) is projected onto a reference ...

Background A prevailing paradigm of physical rehabilitation following neurologic injury is to "assist-as-needed" in completing desired movements. Several research groups are attempting to automate this principle with ...

Advanced statistics have proved to be a crucial tool for basketball coaches in order to improve training skills. Indeed, the performance of the team can be further optimized by studying the behaviour of players under certain ...

Ganglioside-induced differentiation associated protein 1 (GDAP1) gene encodes a protein of the mitochondrial outer membrane and of the mitochondrial membrane contacts with the endoplasmic reticulum (MAMs) and lysosomes. ...

thought of as a process in which the nervous system learns to anticipate the environmental forces to eliminate kinematic error. Here we show that motor adaptation can more generally be modeled as a process in which the ...