Now showing items 1-20 of 27

    • Ageing is associated with deterioration of calcium homeostasis in isolated human right atrial myocytes 

      Herrainz, Adela; Álvarez-García, Jesus; Llach, A; Molina, Cristina E.; Fernandes, Jacqueline; Ferrero-Gregori, Andreu; Rodríguez, Cristina; Vallmitjana Lees, Alexander; Benítez Iglesias, Raúl; Padró, Josep M.; Martínez-González, José; Cinca Cosculluela, Juan; Hove-Madsen, Leif (2015-02-24)
      Article
      Open Access
      Ageing-related cardiac disorders such as heart failure and atrial fibrillation often present with intracellular calcium homeostasis dysfunction. However, knowledge of the intrinsic effects of ageing on cellular calcium ...
    • Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations 

      Riveras Torres, Jose; Calvo, Conrado J.; Llach, Anna; Gúzman Martínez, Gabriela; Caballero, Ricardo; González Gómez, Cristina; Jiménez Borreguero, Luís J.; Guadix, Juan A.; Osorio, Fernando G.; López Otín, Carlos; Herraiz Martínez, Adela; Cabello, Nuria; Vallmitjana Lees, Alexander; Benítez Iglesias, Raúl; Gordon, Leslie B. (2016-11-15)
      Article
      Open Access
      Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disease caused by defective prelamin A processing, leading to nuclear lamina alterations, severe cardiovascular pathology, and premature death. Prelamin A ...
    • Data-based fault detection in chemical processes: Managing records with operator intervention and uncertain labels 

      Askarian, Mahdieh; Benítez Iglesias, Raúl; Graells Sobré, Moisès; Zarghami, Reza (2016-06-23)
      Article
      Open Access
      Developing data-driven fault detection systems for chemical plants requires managing uncertain data labels and dynamic attributes due to operator-process interactions. Mislabeled data is a known problem in computer science ...
    • Detection of calcium release from individual RyR2 clusters in cardiomyocites 

      Nolla Colomer, Carme; Vallmitjana Lees, Alexander; Hove-Madsen, Leif; Benítez Iglesias, Raúl (2020-02)
      Article
      Restricted access - publisher's policy
      Cardiac ryanodine receptors (RyR2s) are Ca2þ release channels clustering in the sarcoplasmic reticulum membrane. These clusters are believed to be the elementary units of Ca2þ release. The distribution of these Ca2þ release ...
    • Detection, properties, and frequency of local calcium release from the sarcoplasmic reticulum in teleost cardiomyocytes 

      Llach, Anna; Molina, Cristina E.; Álvarez Lacalle, Enrique; Tort, Lluis; Benítez Iglesias, Raúl; Hove-Madsen, Leif (2011-08-29)
      Article
      Open Access
      Calcium release from the sarcoplasmic reticulum (SR) plays a central role in the regulation of cardiac contraction and rhythm in mammals and humans but its role is controversial in teleosts. Since the zebrafish is an ...
    • Distribution and function of cardiac ryanodine receptor clusters in live ventricular myocytes 

      Hiess, Florian; Vallmitjana Lees, Alexander; Wang, Ruiwu; Cheng, Hongqiang; ter Keurs, Henk; Chen, Ju; Hove Madsen, Leif; Benítez Iglesias, Raúl; Chen, S. R. Wayne (2015-08-14)
      Article
      Open Access
      The cardiac Ca2+ release channel (ryanodine receptor, RyR2) plays an essential role in excitation-contraction coupling in cardiac muscle cells. Effective and stable excitation-contraction coupling critically depends not ...
    • Dynamic and irregular distribution of RyR2 clusters in the periphery of live ventricular myocytes 

      Hiess, Florian; Detampel, Pascal; Nolla Colomer, Carme; Vallmitjana Lees, Alexander; Ganguly, Anutosh; Amrein, Matthias; ter Keurs, Henk E.D.J; Benítez Iglesias, Raúl; Hove-Madsen, Leif; Chen, S. R. Wayne (2018-01-23)
      Article
      Open Access
      Cardiac ryanodine receptors (RyR2s) are Ca2+ release channels clustering in the sarcoplasmic reticulum membrane. These clusters are believed to be the elementary units of Ca2+ release. The distribution of these Ca2+ release ...
    • Enhanced plant fault diagnosis based on the characterization of transient stages 

      Monroy, Isaac; Benítez Iglesias, Raúl; Escudero Bakx, Gerard; Graells Sobré, Moisès (Pergamon Press, 2011-12-05)
      Article
      Restricted access - publisher's policy
      This paper introduces a data-based fault diagnosis system that includes an enhanced characterization of faults during transient stages. First, data under abnormal operating conditions (AOC) is projected onto a reference ...
    • How to merge observational and physiological data? A case study of motor skills patterns and heart rate in exercise programs for adult women 

      Castañer Balcells, Marta; Puigarnau, Sílvia; Benítez Iglesias, Raúl; Zurloni, Valentino; Camerino, Oleguer (2017-10-01)
      Article
      Open Access
      The present study analyzes individual and group heart rate responses in exercising adult women. The specific aim was to compare responses during routine workout sessions within a community exercise program with responses ...
    • Human-robot cooperative movement training: learning a novel sensory motor transformation during walking with robotic assistance-as-needed 

      Emken, Jeremy L.; Benítez Iglesias, Raúl; Reinkensmeyer, David J. (BioMed Central Ltd., 2007-03-31)
      Article
      Open Access
      Background A prevailing paradigm of physical rehabilitation following neurologic injury is to "assist-as-needed" in completing desired movements. Several research groups are attempting to automate this principle with ...
    • Identification of intracellular calcium dynamics in stimulated cardiomyocytes 

      Vallmitjana Lees, Alexander; Barriga, Montserrat; Nenadic, Zoran; Llach, Anna; Álvarez Lacalle, Enrique; Hove-Madsen, Leif; Benítez Iglesias, Raúl (IEEE Press. Institute of Electrical and Electronics Engineers, 2010)
      Conference report
      Open Access
      We have developed an automatic method for the analysis and identification of dynamical regimes in intracellular calcium patterns from confocal calcium images. The method allows the identification of different dynamical ...
    • Identifying basketball plays from sensor data; towards a low-cost automatic extraction of advanced statistics 

      Arbués Sangüesa, Adrià; Moeslund, Thomas B.; Bahnsen, Chris H.; Benítez Iglesias, Raúl (Institute of Electrical and Electronics Engineers (IEEE), 2017)
      Conference report
      Restricted access - publisher's policy
      Advanced statistics have proved to be a crucial tool for basketball coaches in order to improve training skills. Indeed, the performance of the team can be further optimized by studying the behaviour of players under certain ...
    • Low density lipoproteins promote unstable calcium handling accompanied by reduced SERCA2 and connexin-40 expression in cardiomyocytes 

      Barriga, Montserrat; Cal, Roi; Cabello, Nuria; Llach, Anna; Vallmitjana Lees, Alexander; Benítez Iglesias, Raúl; Badimón, Lina; Cinca, J.; Llorente-Cortés, Vicenta; Hove-Madsen, Leif (2013-03-13)
      Article
      Open Access
      The damaging effects of high plasma levels of cholesterol in the cardiovascular system are widely known, but little attention has been paid to direct effects on cardiomyocyte function. We therefore aimed at testing the ...
    • Mitochondria–lysosome membrane contacts are defective in GDAP1-related Charcot–Marie–Tooth disease 

      Cantarero, Lara; Juárez Escoto, Elena; Civera Tregón, Azahara; Rodríguez Sanz, María; Roldán, Mónica; Benítez Iglesias, Raúl; Hoenicka, Janet; Palau, Francesc (2020-11-06)
      Article
      Restricted access - publisher's policy
      Mutations in the GDAP1 gene cause Charcot–Marie–Tooth (CMT) neuropathy. GDAP1 is an atypical glutathione S-transferase (GST) of the outer mitochondrial membrane and the mitochondrial membrane contacts with the endoplasmic ...
    • Motor adaptation as a greedy optimization of error and effort 

      Emken, Jeremy L.; Benítez Iglesias, Raúl; Sideris, Athanasios; Bobrow, James E.; Reinkensmeyer, David J. (The American Physiological Society, 2007-03-31)
      Article
      Restricted access - publisher's policy
      thought of as a process in which the nervous system learns to anticipate the environmental forces to eliminate kinematic error. Here we show that motor adaptation can more generally be modeled as a process in which the ...
    • Multilevel analysis of calcium dynamics in stimulated cultures of cardiomyocytes 

      Vallmitjana Lees, Alexander; Hove-Madsen, Leif; Barriga, Montserrat; Benítez Iglesias, Raúl (Institute of Electrical and Electronics Engineers (IEEE), 2013)
      Conference report
      Restricted access - publisher's policy
      We present an automatic method to characterize calcium activity in a culture of cardiac cells from a sequence of microscopy fluorescence images. The approach quantifies both the response of each individual cell in the ...
    • Phase-field models in interfacial pattern formation out of equilibrium 

      González Cinca, Ricardo; Folch, R.; Benítez Iglesias, Raúl; Ramírez de la Piscina Millán, Laureano; Casademunt, Jaume; Hernández-Machado, A. (NOVA, 2004-06)
      Part of book or chapter of book
      Open Access
    • Phase-field study of transient stages and fluctuations in solidification 

      Benítez Iglesias, Raúl (Universitat Politècnica de Catalunya, 2005-01-27)
      Doctoral thesis
      Open Access
      L'estudi de la formació de microstructures en processos de solidificació té importants aplicacions científiques i tecnològiques. L'aparició d'aquestes estructures determina les propietats elèctriques i mecàniques del ...
    • Phospholamban knockout breaks arrhythmogenic Ca2+ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice 

      Bai, Yunlong; Jones, Peter; Guo, Jiqing; Zhong, Xiaowei; Clark, Robert; Zhou, Qiang; Wang, Ruiwu; Vallmitjana Lees, Alexander; Benítez Iglesias, Raúl; Hove-Madsen, Leif; Semeniuk, Lisa; Guo, Ang; Song, Long-Sheng; Duff, Henry J.; Chen, S.R. Wayne (2013-07-15)
      Article
      Restricted access - publisher's policy
      Rationale: Phospholamban (PLN) is an inhibitor of cardiac sarco(endo)plasmic reticulum Ca2+ ATPase. PLN knockout (PLN-KO) enhances sarcoplasmic reticulum Ca2+ load and Ca2+ leak. Conversely, PLN-KO accelerates Ca2+ ...
    • Prevention of adenosine A2A receptor activation diminishes beat-to-beat alternation in human atrial myocytes 

      Llacher Alsina, Anna Pilar; Vallmitjana Lees, Alexander; Benítez Iglesias, Raúl; Montiel Dacosta, José Antonio; Cinca Cusculluela, Juan (2016-01-01)
      Article
      Open Access
      © 2015, Springer-Verlag Berlin Heidelberg. Atrial fibrillation (AF) has been associated with increased spontaneous calcium release from the sarcoplasmic reticulum and linked to increased adenosine A2A receptor (A2AR) ...