Now showing items 1-20 of 50

    • 3D printing with star-shaped strands: a new approach to enhance in vivo bone regeneration 

      Raymond Llorens, Santiago; Lehmann, Cyril; Thorel, Emilie; Benítez Iglesias, Raúl; Riveiro Rodríguez, Antonio; Pou Saracho, Juan María; Manzanares Céspedes, Maria Cristina; Franch Serracanta, Jordi; Canal Barnils, Cristina; Ginebra Molins, Maria Pau (Elsevier, 2022-06-01)
      Article
      Open Access
      Covenantee:   Mimetis Biomaterials / Institut de Recerca Sant Joan de Déu / Universidade de Vigo / Universitat de Barcelona / Universitat Autònoma de Barcelona / Institut de Bioenginyeria de Catalunya
      Concave surfaces have shown to promote bone regeneration in vivo. However, bone scaffolds obtained by direct ink writing, one of the most promising approaches for the fabrication of personalized bone grafts, consist mostly ...
    • Ageing is associated with deterioration of calcium homeostasis in isolated human right atrial myocytes 

      Herrainz, Adela; Álvarez-García, Jesus; Llach, A; Molina, Cristina E.; Fernandes, Jacqueline; Ferrero-Gregori, Andreu; Rodríguez, Cristina; Vallmitjana Lees, Alexander; Benítez Iglesias, Raúl; Padró, Josep M.; Martínez-González, José; Cinca Cosculluela, Juan; Hove-Madsen, Leif (2015-02-24)
      Article
      Open Access
      Ageing-related cardiac disorders such as heart failure and atrial fibrillation often present with intracellular calcium homeostasis dysfunction. However, knowledge of the intrinsic effects of ageing on cellular calcium ...
    • Ante-hoc generation of task-agnostic interpretation maps 

      Guna R. T., Akash; Okkath Krishnanunni, Sikha; Benítez Iglesias, Raúl (Institute of Electrical and Electronics Engineers (IEEE), 2023-06-23)
      Article
      Open Access
      Existing explainability approaches for convolutional neural networks (CNNs) are mainly applied after training (post-hoc) which is generally unreliable. Ante-hoc explainers trained simultaneously with the CNN are more ...
    • Beta-blocker treatment of patients with atrial fibrillation attenuates spontaneous calcium release-induced electrical activity 

      Jiménez Sábado, Verónica; Casabella Ramón, Sergi; Llach, Anna; Gich, Ignasi; Casellas Casanova, Sandra; Ciruela, Francisco; Chen, S.R. Wayne; Guerra Ramos, José Mª; Ginel Iglesias, Antonino; Benítez Iglesias, Raúl; Cinca, Juan; Tarifa Lora, Carmen; Hove-Madsen, Leif (Elsevier, 2023-02-01)
      Article
      Open Access
      Aims Atrial fibrillation (AF) has been associated with excessive spontaneous calcium release, linked to cyclic AMP (cAMP)-dependent phosphorylation of calcium regulatory proteins. Because ß-blockers are expected to ...
    • Ca2+-CaM dependent inactivation of RyR2 underlies Ca2+ alternans in intact heart 

      Guo, Wenting; Benítez Iglesias, Raúl; Hove-Madsen, Leif; Álvarez Lacalle, Enrique; Echebarría Domínguez, Blas (2021-02-19)
      Article
      Open Access
      Rationale: Ca2+ alternans plays an essential role in cardiac alternans that can lead to ventricular fibrillation, but the mechanism underlying Ca2+ alternans remains undefined. Increasing evidence suggests that Ca2+ ...
    • Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations 

      Riveras Torres, Jose; Calvo, Conrado J.; Llach, Anna; Gúzman Martínez, Gabriela; Caballero, Ricardo; González Gómez, Cristina; Jiménez Borreguero, Luís J.; Guadix, Juan A.; Osorio, Fernando G.; López Otín, Carlos; Herraiz Martínez, Adela; Cabello, Nuria; Vallmitjana Lees, Alexander; Benítez Iglesias, Raúl; Gordon, Leslie B. (2016-11-15)
      Article
      Open Access
      Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disease caused by defective prelamin A processing, leading to nuclear lamina alterations, severe cardiovascular pathology, and premature death. Prelamin A ...
    • Cardiac ryanodine receptor calcium release deficiency syndrome 

      Guo, Wenting; Benítez Iglesias, Raúl; Hove-Madsen, Leif (2021-02-03)
      Article
      Open Access
      Cardiac ryanodine receptor (RyR2) gain-of-function mutations cause catecholaminergic polymorphic ventricular tachycardia, a condition characterized by prominent ventricular ectopy in response to catecholamine stress, which ...
    • Ceramic-hydrogel composite as carrier for cold-plasma reactive-species: Safety and osteogenic capacity in vivo 

      Solé Martí, Xavier; Labay, Cédric Pierre; Raymond Llorens, Yago; Franch, Jordi; Benítez Iglesias, Raúl; Ginebra Molins, Maria Pau; Canal Barnils, Cristina (Wiley (John Wiley & Sons), 2022-01-01)
      Article
      Open Access
      Covenantee:   Institut de Recerca Sant Joan de Déu / Mimetis Biomaterials / Universitat Autònoma de Barcelona / Institut de Bioenginyeria de Catalunya
      Plasma-treated hydrogels have been put forward as a potential selective osteosarcoma therapy through the release of reactive species to the diseased site. To allow their translation to the clinics, it is crucial to show ...
    • Consells per afrontar un projecte de recerca i innovació - Finançament 

      Benítez Iglesias, Raúl (2023-02-06)
      Audiovisual
      Open Access
      Segon vídeo de la sèrie 'Consells per afrontar un projecte de recerca i innovació', en què Raúl Benítez, professor del Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial a l’Escola d'Enginyeria de ...
    • Data-based fault detection in chemical processes: Managing records with operator intervention and uncertain labels 

      Askarian, Mahdieh; Benítez Iglesias, Raúl; Graells Sobré, Moisès; Zarghami, Reza (2016-06-23)
      Article
      Open Access
      Developing data-driven fault detection systems for chemical plants requires managing uncertain data labels and dynamic attributes due to operator-process interactions. Mislabeled data is a known problem in computer science ...
    • Detection of abnormal cardiac response patterns in cardiac tissue using deep learning 

      Marimon Serra, Xavier; Benítez Iglesias, Raúl (Multidisciplinary Digital Publishing Institute (MDPI), 2022-08-05)
      Article
      Open Access
      This study reports a method for the detection of mechanical signaling anomalies in cardiac tissue through the use of deep learning and the design of two anomaly detectors. In contrast to anomaly classifiers, anomaly detectors ...
    • Detection of calcium release from individual RyR2 clusters in cardiomyocites 

      Nolla Colomer, Carme; Vallmitjana Lees, Alexander; Hove-Madsen, Leif; Benítez Iglesias, Raúl (2020-02)
      Article
      Restricted access - publisher's policy
      Cardiac ryanodine receptors (RyR2s) are Ca2þ release channels clustering in the sarcoplasmic reticulum membrane. These clusters are believed to be the elementary units of Ca2þ release. The distribution of these Ca2þ release ...
    • Detection, properties, and frequency of local calcium release from the sarcoplasmic reticulum in teleost cardiomyocytes 

      Llach, Anna; Molina, Cristina E.; Álvarez Lacalle, Enrique; Tort, Lluis; Benítez Iglesias, Raúl; Hove-Madsen, Leif (2011-08-29)
      Article
      Open Access
      Calcium release from the sarcoplasmic reticulum (SR) plays a central role in the regulation of cardiac contraction and rhythm in mammals and humans but its role is controversial in teleosts. Since the zebrafish is an ...
    • Distribution and function of cardiac ryanodine receptor clusters in live ventricular myocytes 

      Hiess, Florian; Vallmitjana Lees, Alexander; Wang, Ruiwu; Cheng, Hongqiang; ter Keurs, Henk; Chen, Ju; Hove-Madsen, Leif; Benítez Iglesias, Raúl; Chen, S. R. Wayne (2015-08-14)
      Article
      Open Access
      The cardiac Ca2+ release channel (ryanodine receptor, RyR2) plays an essential role in excitation-contraction coupling in cardiac muscle cells. Effective and stable excitation-contraction coupling critically depends not ...
    • Dynamic and irregular distribution of RyR2 clusters in the periphery of live ventricular myocytes 

      Hiess, Florian; Detampel, Pascal; Nolla Colomer, Carme; Vallmitjana Lees, Alexander; Ganguly, Anutosh; Amrein, Matthias; ter Keurs, Henk E.D.J; Benítez Iglesias, Raúl; Hove-Madsen, Leif; Chen, S. R. Wayne (2018-01-23)
      Article
      Open Access
      Cardiac ryanodine receptors (RyR2s) are Ca2+ release channels clustering in the sarcoplasmic reticulum membrane. These clusters are believed to be the elementary units of Ca2+ release. The distribution of these Ca2+ release ...
    • EEBE International Day. Com sol·licitar una plaça d'estudis de mobilitat? 

      Benítez Iglesias, Raúl (2021-12-01)
      Audiovisual
      Open Access
    • EEBE International Day. Round Table by students 

      Benítez Iglesias, Raúl (2021-12-01)
      Audiovisual
      Open Access
    • Enhanced plant fault diagnosis based on the characterization of transient stages 

      Monroy, Isaac; Benítez Iglesias, Raúl; Escudero Bakx, Gerard; Graells Sobré, Moisès (Pergamon Press, 2011-12-05)
      Article
      Restricted access - publisher's policy
      This paper introduces a data-based fault diagnosis system that includes an enhanced characterization of faults during transient stages. First, data under abnormal operating conditions (AOC) is projected onto a reference ...
    • How to merge observational and physiological data? A case study of motor skills patterns and heart rate in exercise programs for adult women 

      Castañer Balcells, Marta; Puigarnau, Sílvia; Benítez Iglesias, Raúl; Zurloni, Valentino; Camerino, Oleguer (2017-10-01)
      Article
      Open Access
      The present study analyzes individual and group heart rate responses in exercising adult women. The specific aim was to compare responses during routine workout sessions within a community exercise program with responses ...
    • Human-robot cooperative movement training: learning a novel sensory motor transformation during walking with robotic assistance-as-needed 

      Emken, Jeremy L.; Benítez Iglesias, Raúl; Reinkensmeyer, David J. (BioMed Central Ltd., 2007-03-31)
      Article
      Open Access
      Background A prevailing paradigm of physical rehabilitation following neurologic injury is to "assist-as-needed" in completing desired movements. Several research groups are attempting to automate this principle with ...