Now showing items 1-7 of 7

    • Cis and trans effects differentially contribute to the evolution of promoters and enhancers 

      Mattioli, Kaia; Oliveros, Winona; Gerhardinger, Chiara; Andergassen, Daniel; Maass, Philipp G.; Rinn, John L.; Melé, Marta (Springer Nature, 2020-08-20)
      Article
      Open Access
      Background Gene expression differences between species are driven by both cis and trans effects. Whereas cis effects are caused by genetic variants located on the same DNA molecule as the target gene, trans effects are ...
    • Epigenetic characterization of cholangiocarcinomas 

      Oliveros, Winona; Peiró, Sandra; Melé, Marta (Barcelona Supercomputing Center, 2021-05)
      Conference report
      Open Access
      Cholangiocarcinoma (CCA) is a rare type of cancer and accounts for 10-20% of primary liver diagnosed cancers, being the second most common hepatobiliary malignancy.The only prospect of a long-term cure for these malignancies ...
    • Genetic, parental and lifestyle factors influence telomere length 

      Andreu Sánchez, Sergio; Aubert, Geraldine; Ripoll Cladellas, Aida; Henkelman, Sandra; Zhernakova, Daria V.; Melé, Marta (Nature Research, 2022)
      Article
      Open Access
      The average length of telomere repeats (TL) declines with age and is considered to be a marker of biological ageing. Here, we measured TL in six blood cell types from 1046 individuals using the clinically validated Flow-FISH ...
    • Predicting Gastric Cancer Molecular Subtypes from Gene Expression Data 

      Moreno, Marta; Sousa, Abel; Melé, Marta; Oliveira, Rui; Ferreira, Pedro G. (MDPI, 2020)
      Article
      Open Access
      Stomach cancer is a complex disease and one of the leading causes of cancer mortality in the world. With the view to improve patient diagnosis and prognosis, it has been stratified into four molecular subtypes. In this ...
    • Single-cell profiling of Ebola virus disease In Vivo reveals viral and host dynamics 

      Kotliar, Dylan; Lin, Aaron E; Logue, James; Hughes, Travis K; Khoury, Nadine M; Melé, Marta (Elsevier, 2020-11)
      Article
      Open Access
      Ebola virus (EBOV) causes epidemics with high mortality yet remains understudied due to the challenge of experimentation in high-containment and outbreak settings. Here, we used single-cell transcriptomics and CyTOF-based ...
    • Unveiling the transcriptional and cellular landscape of age across human tissues 

      Ripoll-Cladellas, Aida; G.P. van der Wijst, Monique; Melé, Marta (Barcelona Supercomputing Center, 2021-05)
      Conference report
      Open Access
      As the aging population grows progressively around the globe, the need to research and develop strategies to healthy aging is ever more critical and takes on new urgency1. Primary hallmarks of aging include cell autonomous ...
    • Whole genome sequencing delineates regulatory, copy number, and cryptic splice variants in early onset cardiomyopathy 

      Lesurf, Robert; Said, Abdelrahman; Akinrinade, Oyediran; Breckpot, Jeroen; Delfosse, Kathleen; Oliveros, Winona; Melé, Marta (Nature Research, 2022-03)
      Article
      Open Access
      Cardiomyopathy (CMP) is a heritable disorder. Over 50% of cases are gene-elusive on clinical gene panel testing. The contribution of variants in non-coding DNA elements that result in cryptic splicing and regulate gene ...