Now showing items 1-5 of 5

  • Beyond spectral tuning: human cone visual pigments adopt different transient conformations for chromophore regeneration 

    Srinivasan, Sundaramoorthy; Cordomí, Arnau; Ramon Portés, Eva; Garriga Solé, Pere (2016-03)
    Article
    Open Access
    Human red and green visual pigments are seven transmembrane receptors of cone photoreceptor cells of the retina that mediate color vision. These pigments share a very high degree of homology and have been assumed to feature ...
  • Human blue cone opsin regeneration involves secondary retinal binding with analog specificity 

    Srinivasan, Sundaramoorthy; Fernández Sampedro, Miguel Ángel; Morillo Cazorla, Margarita; Ramon Portés, Eva; Jiménez Rosés, Mireia; Cordomi, Arnau; Garriga Solé, Pere (2018-03-27)
    Article
    Open Access
    Human color vision is mediated by the red, green, and blue cone visual pigments. Cone opsins are G-protein-coupled receptors consisting of an opsin apoprotein covalently linked to the 11-cis-retinal chromophore. All visual ...
  • Ligand binding mechanisms in human cone visual pigments 

    Srinivasan, Sundaramoorthy; Guixà González, Ramon; Cordomí, Arnau; Garriga Solé, Pere (2019-03-07)
    Article
    Restricted access - publisher's policy
    Vertebrate vision starts with light absorption by visual pigments in rod and cone photoreceptor cells of the retina. Rhodopsin, in rod cells, responds to dim light, whereas three types of cone opsins (red, green, and blue) ...
  • Stability and ligand binding properties of human cone visual pigments 

    Srinivasan, Sundaramoorthy (Universitat Politècnica de Catalunya, 2015-10-02)
    Doctoral thesis
    Open Access
    Human color perception is mediated by cone photoreceptor cells which mainly locate on the fovea of the eye. Bright light activates the photosensitive opsin pigments which are embedded in the outer segment membrane discs ...
  • Structural and functional alterations associated with deutan N94K and R330Q mutations of green cone opsin 

    Srinivasan, Sundaramoorthy; Fernández Sampedro, Miguel Antonio; Ramon Portés, Eva; Garriga Solé, Pere (2017-07-01)
    Article
    Restricted access - publisher's policy
    Deuteranopia is an X-linked congenital dichromatic condition in which single point mutations in green cone opsin lead to defective non-functional cone photoreceptor cells. Green cone opsin belongs to the G protein-coupled ...