Now showing items 1-17 of 17

    • 3D-printed porous Ti6Al4V alloys with silver coating combine osteocompatibility and antimicrobial properties 

      Díez Escudero, Anna; Andersson, Brittmarie; Carlsson, Elin; Recker, Benjamin; Link, Helmut; Järhult, Josef D.; Hailer, Nils P. (Elsevier, 2021-12-29)
      Article
      Open Access
      Additive manufacturing allows for the production of porous metallic implants for use in orthopaedics, providing excellent mechanical stability and osseointegration. However, the increased surface area of such porous implants ...
    • A microfluidic-based approach to investigate the inflammatory response of macrophages to pristine and drug-loaded nanostructured hydroxyapatite 

      Carter, Sarah-Sophia D.; Atif, Abdul-Raouf; Díez Escudero, Anna; Grape, Maja; Ginebra Molins, Maria Pau; Tenje, Maria; Mestres, Gemma (Elsevier, 2022-12-01)
      Article
      Open Access
      Covenantee:   Uppsala universitet / Institut de Bioenginyeria de Catalunya
      The in vitro biological characterization of biomaterials is largely based on static cell cultures. However, for highly reactive biomaterials such as calcium-deficient hydroxyapatite (CDHA), this static environment has ...
    • Effect of calcium phosphate heparinization on the in vitro inflammatory response and osteoclastogenesis of human blood precursor cells 

      Díez Escudero, Anna; Torreggiani, E.; Pompo, Gemma di; Español Pons, Montserrat; Persson, Cecilia; Ciapetti, Gabriela; Baldini, Nicola; Ginebra Molins, Maria Pau (2019-01-01)
      Article
      Open Access
      Covenantee:   Istituto Ortopedico Rizzoli / Uppsala universitet / Università di Bologna / Institut de Bioenginyeria de Catalunya
      The immobilization of natural molecules on synthetic bone grafts stands as a strategy to enhance their biological interactions. During the early stages of healing, immune cells and osteoclasts (OC) modulate the inflammatory ...
    • Focus ion beam/scanning electron microscopy characterization of osteoclastic resorption of calcium phosphate substrates 

      Díez Escudero, Anna; Español Pons, Montserrat; Montufar Jiménez, Edgar Benjamin; Pompo, Gemma di; Ciapetti, Gabriela; Baldini, Nicola; Ginebra Molins, Maria Pau (2017-02-01)
      Article
      Open Access
      Covenantee:   Istituto Ortopedico Rizzoli
      This article presents the application of dual focused ion beam/scanning electron microscopy (FIB-SEM) imaging for preclinical testing of calcium phosphates with osteoclast precursor cells and how this high-resolution imaging ...
    • Functionalized silk promotes cell migration into calcium phosphate cements by providing macropores and cell adhesion motifs 

      Widhe, Mona; Díez Escudero, Anna; Ginebra Molins, Maria Pau; Persson, Cecilia; Hedhammar, My; Mestres, Gemma; Yuling, Liu; Ringström, Nathalie (2022-11-01)
      Article
      Open Access
      Covenantee:   Kungliga Tekniska högskolan / Uppsala universitet / Institut de Bioenginyeria de Catalunya
      Calcium phosphate cements (CPCs) are attractive synthetic bone grafts as they possess osteoconductive and osteoinductive properties. Their biomimetic synthesis grants them an intrinsic nano- and microporosity that resembles ...
    • Heparinization of beta tricalcium phosphate: osteo-immunomodulatory effects 

      Díez Escudero, Anna; Español Pons, Montserrat; Bonany Mariñosa, Mar; Persson, Cecilia; Ginebra Molins, Maria Pau (2018-03-07)
      Article
      Open Access
      Immune cells play a vital role in regulating bone dynamics. This has boosted the interest in developing biomaterials that can modulate both the immune and skeletal systems. In this study, calcium phosphates discs (i.e., ...
    • High-aspect-ratio nanostructured hydroxyapatite: towards new functionalities for a classical material 

      Díez Escudero, Anna; Español Pons, Montserrat; Ginebra Molins, Maria Pau (Royal Society of Chemistry (RSC), 2024)
      Article
      Open Access
      Hydroxyapatite-based materials have been widely used in countless applications, such as bone regeneration, catalysis, air and water purification or protein separation. Recently, much interest has been given to controlling ...
    • Impact of biomimicry in the design of osteoinductive bone substitutes: nanoscale matters 

      Barba Serrahima, Albert; Díez Escudero, Anna; Español Pons, Montserrat; Bonany Mariñosa, Mar; Sadowska, Joanna Maria; Guillem Martí, Jordi; Ohman, Caroline; Persson, Cecilia; Manzanares, Maria Cristina; Franch, Jordi; Ginebra Molins, Maria Pau (2019-01-01)
      Article
      Open Access
      Covenantee:   Universitat Autònoma de Barcelona / Uppsala universitet / Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental / Institut de Bioenginyeria de Catalunya
      Bone apatite consists of carbonated calcium-deficient hydroxyapatite (CDHA) nanocrystals. Biomimetic routes allow fabricating synthetic bone grafts that mimic biological apatite. In this work, we explored the role of two ...
    • In vitro degradation of calcium phosphates: Effect of multiscale porosity, textural properties and composition 

      Díez Escudero, Anna; Español Pons, Montserrat; Beats, Sean; Ginebra Molins, Maria Pau (2017-09-15)
      Article
      Open Access
      The capacity of calcium phosphates to be replaced by bone is tightly linked to their resorbability. However, the relative importance of some textural parameters on their degradation behavior is still unclear. The present ...
    • Ion-doping as a strategy to modulate hydroxyapatite nanoparticle internalization 

      Zhao, Zhitong; Español Pons, Montserrat; Guillem Martí, Jordi; Kempf, Doreen; Díez Escudero, Anna; Ginebra Molins, Maria Pau (2016)
      Article
      Open Access
      Although it is widely acknowledged that ionic substitutions on bulk hydroxyapatite substrates have a strong impact on their biological performance, little is known of their effect on nanoparticles (NPs) especially when ...
    • Osteoclast differentiation from human blood precursors on biomimetic calcium-phosphate substrates 

      Ciapetti, Gabriela; Pompo, Gemma di; Avnet, Sofia; Martini, Desirée; Díez Escudero, Anna; Montufar Jiménez, Edgar Benjamin; Ginebra Molins, Maria Pau; Baldini, Nicola (2017-03-01)
      Article
      Open Access
      Covenantee:   Istituto Ortopedico Rizzoli
      The design of synthetic bone grafts to foster bone formation is a challenge in regenerative medicine. Understanding the interaction of bone substitutes with osteoclasts is essential, since osteoclasts not only drive a ...
    • Osteogenesis by foamed and 3D-printed nanostructured calcium phosphate scaffolds: Effect of pore architecture 

      Barba, Albert; Maazouz, Yassine; Díez Escudero, Anna; Español Pons, Montserrat; Montufar Jiménez, Edgar Benjamin; Ginebra Molins, Maria Pau (Elsevier, 2018-10-01)
      Article
      Open Access
      There is an urgent need of synthetic bone grafts with enhanced osteogenic capacity. This can be achieved by combining biomaterials with exogenous growth factors, which however can have numerous undesired side effects, but ...
    • Osteoinduction by foamed and 3D-printed calcium phosphate scaffolds: effect of nanostructure and pore architecture 

      Barba Serrahima, Albert; Díez Escudero, Anna; Maazouz, Yassine; Rappe, K.; Español Pons, Montserrat; Montufar Jiménez, Edgar Benjamin; Bonany Mariñosa, Mar; Sadowska, Joanna Maria; Guillem Martí, Jordi; Ohman, Caroline; Persson, Cecilia; Manzanares, Maria Cristina; Franch Serracanta, Jordi; Ginebra Molins, Maria Pau (2017-12-06)
      Article
      Open Access
      Covenantee:   Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animal / Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental
      Some biomaterials are osteoinductive, that is, they are able to trigger the osteogenic process by inducing the differentiation of mesenchymal stem cells to the osteogenic lineage. Although the underlying mechanism is still ...
    • Production, characterization and dispersion of nanohydroxyapatite 

      Díez Escudero, Anna (Universitat Politècnica de Catalunya, 2012-06)
      Master thesis
      Restricted access - author's decision
      Over the past few decades, various investigations have highlighted the importance of mimicking bone for tissue engineering and bone replacement applications. The hierarchy, chemistry and morphology existing in bone are ...
    • The effect of PCL addition on 3D-printable PLA/HA composite filaments for the treatment of bone defects. 

      Akerlund, Elin; Díez Escudero, Anna; Grzeszczak, Ana; Persson, Cecilia (Multidisciplinary Digital Publishing Institute (MDPI), 2022-08-13)
      Article
      Open Access
      The still-growing field of additive manufacturing (AM), which includes 3D printing, has enabled manufacturing of patient-specific medical devices with high geometrical accuracy in a relatively quick manner. However, the ...
    • Trabecular titanium for orthopedic applications: balancing antimicrobial with osteoconductive properties by varying silver contents 

      Díez Escudero, Anna; Carlsson, Elin; Andersson, Brittmarie; Järhult, Josef D.; Hailer, Nils P. (2022-08-25)
      Article
      Open Access
      Covenantee:   Uppsala universitet
      Periprosthetic joint infection (PJI) and implant loosening are the most common complications after joint replacement surgery. Due to their increased surface area, additively manufactured porous metallic implants provide ...
    • Tuning the biological performance of calcium phosphates through microstructural and chemical modifications 

      Díez Escudero, Anna (Universitat Politècnica de Catalunya, 2017-11-13)
      Doctoral thesis
      Open Access
      Bone is the most transplanted tissue after blood. As pointed out by the World Health Organization, musculoskeletal diseases can potentially rise as the fourth largest cause of disability within the next years. Unfortunately, ...