Now showing items 1-9 of 9

  • Focus ion beam/scanning electron microscopy characterization of osteoclastic resorption of calcium phosphate substrates 

    Díez Escudero, Anna; Español Pons, Montserrat; Montufar Jiménez, Edgar Benjamin; Pompo, Gemma di; Ciapetti, Gabriela; Baldini, Nicola; Ginebra Molins, Maria Pau (2017-02-01)
    Article
    Open Access
    Covenantee:  Istituto Ortopedico Rizzoli
    This article presents the application of dual focused ion beam/scanning electron microscopy (FIB-SEM) imaging for preclinical testing of calcium phosphates with osteoclast precursor cells and how this high-resolution imaging ...
  • Heparinization of beta tricalcium phosphate: osteo-immunomodulatory effects 

    Díez Escudero, Anna; Español Pons, Montserrat; Bonany Mariñosa, Mar; Persson, Cecilia; Ginebra Molins, Maria Pau (2018-03-07)
    Article
    Open Access
    Immune cells play a vital role in regulating bone dynamics. This has boosted the interest in developing biomaterials that can modulate both the immune and skeletal systems. In this study, calcium phosphates discs (i.e., ...
  • In vitro degradation of calcium phosphates: Effect of multiscale porosity, textural properties and composition 

    Díez Escudero, Anna; Español Pons, Montserrat; Beats, Sean; Ginebra Molins, Maria Pau (2017-09-15)
    Article
    Open Access
    The capacity of calcium phosphates to be replaced by bone is tightly linked to their resorbability. However, the relative importance of some textural parameters on their degradation behavior is still unclear. The present ...
  • Ion-doping as a strategy to modulate hydroxyapatite nanoparticle internalization 

    Zhao, Zhitong; Español Pons, Montserrat; Guillem Martí, Jordi; Kempf, Doreen; Díez Escudero, Anna; Ginebra Molins, Maria Pau (2016)
    Article
    Open Access
    Although it is widely acknowledged that ionic substitutions on bulk hydroxyapatite substrates have a strong impact on their biological performance, little is known of their effect on nanoparticles (NPs) especially when ...
  • Osteoclast differentiation from human blood precursors on biomimetic calcium-phosphate substrates 

    Ciapetti, Gabriela; Pompo, Gemma di; Avnet, Sofia; Martini, Desirée; Díez Escudero, Anna; Montufar Jiménez, Edgar Benjamin; Ginebra Molins, Maria Pau; Baldini, Nicola (2017-03-01)
    Article
    Open Access
    Covenantee:  Istituto Ortopedico Rizzoli
    The design of synthetic bone grafts to foster bone formation is a challenge in regenerative medicine. Understanding the interaction of bone substitutes with osteoclasts is essential, since osteoclasts not only drive a ...
  • Osteogenesis by foamed and 3D-printed nanostructured calcium phosphate scaffolds: Effect of pore architecture 

    Barba, Albert; Maazouz, Yassine; Díez Escudero, Anna; Español Pons, Montserrat; Montufar Jiménez, Edgar Benjamin; Ginebra Molins, Maria Pau (Elsevier, 2018-10-01)
    Article
    Restricted access - publisher's policy
    There is an urgent need of synthetic bone grafts with enhanced osteogenic capacity. This can be achieved by combining biomaterials with exogenous growth factors, which however can have numerous undesired side effects, but ...
  • Osteoinduction by foamed and 3D-printed calcium phosphate scaffolds: effect of nanostructure and pore architecture 

    Barba Serrahima, Albert; Díez Escudero, Anna; Maazouz, Yassine; Rappe, K.; Español Pons, Montserrat; Montufar Jiménez, Edgar Benjamin; Bonany Mariñosa, Mar; Sadowska, Joanna Maria; Guillem Martí, Jordi; Ohman, Caroline; Persson, Cecilia; Manzanares, Maria Cristina; Franch Serracanta, Jordi; Ginebra Molins, Maria Pau (2017-12-06)
    Article
    Open Access
    Covenantee:  Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animal / Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental
    Some biomaterials are osteoinductive, that is, they are able to trigger the osteogenic process by inducing the differentiation of mesenchymal stem cells to the osteogenic lineage. Although the underlying mechanism is still ...
  • Production, characterization and dispersion of nanohydroxyapatite 

    Díez Escudero, Anna (Universitat Politècnica de Catalunya, 2012-06)
    Master thesis
    Restricted access - author's decision
    Over the past few decades, various investigations have highlighted the importance of mimicking bone for tissue engineering and bone replacement applications. The hierarchy, chemistry and morphology existing in bone are ...
  • Tuning the biological performance of calcium phosphates through microstructural and chemical modifications 

    Díez Escudero, Anna (Universitat Politècnica de Catalunya, 2017-11-13)
    Doctoral thesis
    Open Access
    Bone is the most transplanted tissue after blood. As pointed out by the World Health Organization, musculoskeletal diseases can potentially rise as the fourth largest cause of disability within the next years. Unfortunately, ...