Now showing items 1-4 of 4

    • Genuine antiplasticizing effect of water on a glass-former drug 

      Ruiz Tabbia, Guadalupe Natalia; Romanini, Michela; Hauptmann, Astrid; Loerting, Thomas; Shalaev, Evgenyi; Tamarit Mur, José Luis; Pardo Soto, Luis Carlos; Macovez, Roberto (Macmillan Publishers, 2017-08-07)
      Article
      Open Access
      Water is the most important plasticizer of biological and organic hydrophilic materials, which generally exhibit enhanced mechanical softness and molecular mobility upon hydration. The enhancement of the molecular dynamics ...
    • On the structure of prilocaine in aqueous and amphiphilic solutions 

      Silva-Santisteban López, Alvaro; Steinke, Nicola; Johnston, Andrew J; Ruiz Tabbia, Guadalupe Natalia; Pardo Soto, Luis Carlos; McLain, Sylvia E. (2017-05-28)
      Article
      Open Access
      The solvation of prilocaine has been investigated in pure water and in an amphiphilic methanol/water solution using a combination of neutron diffraction with isotopic substitution augmented by Empirical Potential Structure ...
    • Relaxation dynamics and crystallization kinetics of glass-forming drugs 

      Ruiz Tabbia, Guadalupe Natalia (Universitat Politècnica de Catalunya, 2018-09-14)
      Doctoral thesis
      Open Access
      Glassy phases play an important role in our daily life and in many industries such as the food, pharmaceutical, and construction and are responsible for certain vital mechanisms in living species. Whereas crystals are solid ...
    • Tuning molecular dynamics by hydration and confinement: Antiplasticizing effect of water in hydrated prilocaine nanoclusters 

      Ruiz Tabbia, Guadalupe Natalia; Combarro Palacios, Izaskun; McLain, Sylvia E.; Schwartz, Gustavo Ariel; Pardo Soto, Luis Carlos; Cerveny Murcia, Silvina; Macovez, Roberto (Royal Society of Chemistry (RSC), 2019-01-01)
      Article
      Open Access
      In glass-forming substances, the addition of water tends to produce the effect of lowering the glass transition temperature, Tg. In a previous work by some of us (Ruiz et al., Sci. Rep., 2017, 7, 7470) we reported on a ...