Now showing items 1-3 of 3

  • A new approach for sizing trials with composite binary endpoints using anticipated marginal values and accounting for the correlation between components 

    Bofill Roig, Marta; Gómez Melis, Guadalupe (2019-05-20)
    Article
    Restricted access - publisher's policy
    Composite binary endpoints are increasingly used as primary endpoints in clinical trials. When designing a trial, it is crucial to determine the appropriate sample size for testing the statistical differences between ...
  • Relative efficiency between two tests 

    Bofill Roig, Marta (Universitat Politècnica de Catalunya / Universitat de Barcelona, 2016-06)
    Master thesis
    Restricted access - author's decision
    The choice of the primary endpoint is an important issue when designing a clinical trial. The motivation of this Master thesis is to develop a methodology based on the Asymptotic Relative Efficiency (ARE) that discerns ...
  • Selection of composite binary endpoints in clinical trials 

    Bofill Roig, Marta; Gómez Melis, Guadalupe (2017-10-12)
    Article
    Open Access
    The choice of a primary endpoint is an important issue when designing a clinical trial. It is common to use composite endpoints as a primary endpoint because it increases the number of observed events, captures more ...