A new approach for sizing trials with composite binary endpoints using anticipated marginal values and accounting for the correlation between components Bofill Roig, Marta; Gómez Melis, Guadalupe (2019-05-20)
Restricted access - publisher's policyComposite binary endpoints are increasingly used as primary endpoints in clinical trials. When designing a trial, it is crucial to determine the appropriate sample size for testing the statistical differences between ...
Bofill Roig, Marta (Universitat Politècnica de Catalunya / Universitat de Barcelona, 2016-06)
Restricted access - author's decisionThe choice of the primary endpoint is an important issue when designing a clinical trial. The motivation of this Master thesis is to develop a methodology based on the Asymptotic Relative Efficiency (ARE) that discerns ...
Bofill Roig, Marta; Gómez Melis, Guadalupe (2017-10-12)
Open AccessThe choice of a primary endpoint is an important issue when designing a clinical trial. It is common to use composite endpoints as a primary endpoint because it increases the number of observed events, captures more ...