A new approach for sizing trials with composite binary endpoints using anticipated marginal values and accounting for the correlation between components Bofill Roig, Marta; Gómez Melis, Guadalupe (2019-05-20)
Open AccessComposite binary endpoints are increasingly used as primary endpoints in clinical trials. When designing a trial, it is crucial to determine the appropriate sample size for testing the statistical differences between ...
Bofill Roig, Marta; Cortés Martínez, Jordi; Gómez Melis, Guadalupe (2020-01-10)
Open AccessThis article considers the combination of two binary or two time-to-event endpoints to form the primary composite endpoint for leading a trial. • It discusses the relative efficiency of choosing a composite endpoint over ...
Bofill Roig, Marta (Universitat Politècnica de Catalunya / Universitat de Barcelona, 2016-06)
Restricted access - author's decisionThe choice of the primary endpoint is an important issue when designing a clinical trial. The motivation of this Master thesis is to develop a methodology based on the Asymptotic Relative Efficiency (ARE) that discerns ...
Bofill Roig, Marta; Gómez Melis, Guadalupe (2017-10-12)
Open AccessThe choice of a primary endpoint is an important issue when designing a clinical trial. It is common to use composite endpoints as a primary endpoint because it increases the number of observed events, captures more ...
Statistical methods and software for clinical trials with binary and survival endpoints : efficiency, sample size and two-sample comparison Bofill Roig, Marta (Universitat Politècnica de Catalunya, 2020-12-22)
Open AccessDefining the scientific question is the starting point for any clinical study. However, even though the main objective is generally clear, how this is addressed is not usually straightforward. Clinical studies very often ...