Now showing items 1-20 of 69

    • 3D silicon doped hydroxyapatite scaffolds decorated with Elastin-like Recombinamers for bone regenerative medicine 

      Vila, Mercedes; García, Ana; Girotti, Alessandra; Alonso, Matilde; Rodriguez Cabello, Jose Carlos; Gonzalez Vazquez, Arlyng; Planell Estany, Josep Anton; Engel López, Elisabeth; Buján, Julia; García Honduvilla, Natalio; Vallet Regi, Maria (2016-11-01)
      Article
      Open Access
      The current study reports on the manufacturing by rapid prototyping technique of three-dimensional (3D) scaffolds based on silicon substituted hydroxyapatite with Elastin-like Recombinamers (ELRs) functionalized surfaces. ...
    • A bioactive elastin-like recombinamer reduces unspecific protein adsorption and enhances cell response on titanium surfaces. 

      Salvagni, Emiliano; Berguig, Geoffrey; Engel López, Elisabeth; Rodriguez Cabello, Jose Carlos; Coullerez, Geraldine; Textor, Marcus; Planell Estany, Josep Anton; Gil Mur, Francisco Javier; Aparicio Bádenas, Conrado José (2013-10-17)
      Article
      Restricted access - publisher's policy
      Covenantee:   University of Minnesota School of Dentistry / Universidad de Valladolid
      We present the immobilization on synthetic substrates of elastin-like recombinamers (ELR) that combine a bioactive motif for cell adhesion with protein antifouling properties. Physical adsorption of the recombinamers and ...
    • A novel hybrid nanofibrous strategy to target progenitor cells for cost-effective in situ angiogenesis 

      Sachot, Nadège; Castaño Linares, Óscar; Oliveira, Hugo; Martí Muñoz, Joan; Roguska, Agata; Amedee, Joelle; Lewandowska, Malgorzata; Planell Estany, Josep Anton; Engel López, Elisabeth (Royal Society of Chemistry, 2016-11-02)
      Article
      Open Access
      Although the impact of composites based on Ti-doped calcium phosphate glasses is low compared with that of bioglass, they have been already shown to possess great potential for bone tissue engineering. Composites made of ...
    • A novel hybrid nanofibrous strategy to target progenitor cells for cost-effective: In situ angiogenesis 

      Sachot, Nadege; Castaño Linares, Óscar; Oliveira, Hugo; Martí Muñoz, Joan; Roguska, Agata; Amedee, Joelle; Lewandowska, Malgorzata; Planell Estany, Josep Anton; Engel López, Elisabeth (Royal Society of Chemistry, 2016-09-22)
      Article
      Open Access
      Although the impact of composites based on Ti-doped calcium phosphate glasses is low compared with that of bioglass, they have been already shown to possess great potential for bone tissue engineering. Composites made of ...
    • Alendronate and etidronate do not regulate interleukin 6 and 11 synthesis in normal human osteoblasts in culture 

      Engel López, Elisabeth; Serrano, Sergi; Mariñoso, Maria Lluïsa; Lloreta, Josep; Ulloa, Fausto; Nogués, Xavier; Díez-Pérez, Adolfo; Carbonell, Jordi (2003)
      Article
      Open Access
      Bisphosphonates exert a potent inhibitory effect on bone resorption. Several studies have been performed, with contradictory results, to ascertain whether the effect of bisphosphonates on osteoclasts could be produced, ...
    • An efficient and reproducible method to culture Bergmann and cortical radial glia using textured PMMA 

      Álvarez Pinto, Zaída; Sena, Elena; Mattotti, Marta; Engel López, Elisabeth; Alcantara, Soledad (2014-07-30)
      Article
      Restricted access - publisher's policy
      Radial glia cells comprise the principal population of neural stem cells (NSC) during development. Attempts to develop reproducible radial glia and NSC culture methods have met with variable results, yielding non-adherent ...
    • Angiogenesis in bone regeneration: tailored calcium release in hybrid fibrous scaffolds 

      Castaño Linares, Óscar; Sachot, Nadège; Xuriguera Martin, Elena; Engel López, Elisabeth; Planell Estany, Josep Anton; Park, Jaegyun; Jin, Guang-Zhen; Kim, Tae-Hyun; Kim, Joong-Hyun; Kim, Hae-Won (2014-05-28)
      Article
      Restricted access - publisher's policy
      Covenantee:   Tan'guk Taehakkyo
      In bone regeneration, silicon-based calcium phosphate glasses (Bioglasses) have been widely used since the 1970s. However, they dissolve very slowly because of their high amount of Si (SiO2 > 45%). Recently, our group has ...
    • Biomimetic treatments on dental implants for immediate loading applications 

      Gil Mur, Francisco Javier; Aparicio Bádenas, Conrado José; Salvagni, Emiliano; Werner, Michael; Engel López, Elisabeth; Pegueroles Neyra, Marta; Rodriguez-Cabello, C.; Munoz, F; Planell Estany, Josep Anton (2009-06)
      Article
      Restricted access - publisher's policy
      Covenantee:   Universidad de Valladolid
      Commercially pure titanium (cp Ti) dental implants have been widely and successfully used with high rates of clinical success in normal situations. However, there is still a lack of reliable synthetic materials to be used ...
    • Chitosan/PEGDA based scaffolds as bioinspired materials to control in vitro angiogenesis 

      Soriente, Alessandra; Pérez Amodio, Soledad Graciela; Fasolino, Ines; Raucci, Maria Grazia; Demitri, Christian; Engel López, Elisabeth; Ambrosio, Luigi (Elsevier, 2021-01-01)
      Article
      Restricted access - publisher's policy
      In the current work, our purpose was based on the assessment of bioactive chitosan (CS)/Poly(ethylene glycol) diacrylate (PEGDA) based scaffolds ability to stimulate in vitro angiogenesis process. The bioactivation of the ...
    • Chondroinductive alginate-based hydrogels having graphene oxide for 3D printed scaffold fabrication 

      Olate Moya, Felipe; Mateos Timoneda, Miguel Ángel; Engel López, Elisabeth; Arens, Lukas; Wilhelm, Manfred; Palza, Humberto (2020-01-07)
      Article
      Open Access
      Scaffolds based on bioconjugated hydrogels are attractive for tissue engineering because they can partly mimic human tissue characteristics. For example, they can further increase their bioactivity with cells. However, ...
    • Co-assembled and microfabricated bioactive membranes 

      Mendes, Ana C.; Smith, Katherine H.; Tejeda Montes, Esther; Engel López, Elisabeth; Reis, Rui L.; Azevedo, Elena S.; Mata, Álvaro (2012-09-03)
      Article
      Restricted access - publisher's policy
      The fabrication of hierarchical and bioactive self-supporting membranes, which integrate physical and biomolecular elements, using a single-step process that combines molecular self-assembly with soft lithography ...
    • Control of microenvironmental cues with a smart biomaterial composite promotes endothelial progenitor cell angiogenesis 

      Aguirre, Adrián; Gonzalez, Arlyng; Navarro, Melba; Castaño Linares, Óscar; Planell Estany, Josep Anton; Engel López, Elisabeth (2012-09)
      Article
      Open Access
      Smart biomaterials play a key role when aiming at successful tissue repair by means of regenerative medicine approaches, and are expected to contain chemical as well as mechanical cues that will guide the regenerative ...
    • Development and angiogenic potential of cell-derived microtissues using microcarrier-template 

      Rubi Sans, Gerard; Cano Garcia, Irene; Pérez Amodio, Soledad Graciela; Blanco, Bárbara; Mateos Timoneda, Miguel Ángel; Engel López, Elisabeth (2021-02-25)
      Article
      Open Access
      Tissue engineering and regenerative medicine approaches use biomaterials in combination with cells to regenerate lost functions of tissues and organs to prevent organ transplantation. However, most of the current strategies ...
    • Development of a novel automatable fabrication method based on electrospinning co electrospraying for rotator cuff augmentation patches 

      Rey Viñoles, Sergi; Castaño Linares, Óscar; Ruiz Macarrilla, Leonardo; Llorens, Xavier; Mora Guix, José M.; Engel López, Elisabeth; Mateos Timoneda, Miguel Ángel (Public Library of Science (PLOS), 2019-01-01)
      Article
      Open Access
      Rotator cuff tear is one of the most common shoulder diseases. Rotator cuff augmentation (RCA) is trying to solve the high retear failure percentage after the surgery procedures (20–90%). The ideal augmentation patch must ...
    • Development of a self-assembled peptide/methylcellulose-based bioink for 3D bioprinting 

      Cofiño, Carla; Pérez Amodio, Soledad Graciela; Semino, Carlos; Engel López, Elisabeth; Mateos Timoneda, Miguel Ángel (2019-11-13)
      Article
      Open Access
      The introduction of 3D bioprinting to fabricate living constructs with tailored architecture has provided a new paradigm for biofabrication, with the potential to overcome several drawbacks of conventional scaffold-based ...
    • Development of a three-dimensional bioengineered platform for articular cartilage regeneration 

      Rubi Sans, Gerard; Recha Sancho, Lourdes; Pérez Amodio, Soledad Graciela; Mateos Timoneda, Miguel Ángel; Semino Margrett, Carlos Eduardo; Engel López, Elisabeth (2020-01-01)
      Article
      Open Access
      Degenerative cartilage pathologies are nowadays a major problem for the world population. Factors such as age, genetics or obesity can predispose people to suffer from articular cartilage degeneration, which involves severe ...
    • Development of tailored and self-mineralizing citric acid-crosslinked hydrogels for in situ bone regeneration 

      Sanchez Ferrero, Aitor; Mata, Álvaro; Mateos Timoneda, Miguel Ángel; Rodriguez Cabello, Jose Carlos; Alonso, Matilde; Planell Estany, Josep Anton; Engel López, Elisabeth (2015-11-01)
      Article
      Open Access
      Covenantee:   Universidad de Valladolid
      Bone tissue engineering demands alternatives overcoming the limitations of traditional approaches in the context of a constantly aging global population. In the present study, elastin-like recombinamers hydrogels were ...
    • Differential neuronal and glial behavior on flat and micro patterned chitosan films 

      Mattotti, Marta; Álvarez Pinto, Zaída; Delgado Muñoz, Luis; Mateos Timoneda, Miguel Ángel; Aparicio, Conrado; Planell Estany, Josep Anton; Alcántara Horrillo, Soledad; Engel López, Elisabeth (2017-10-01)
      Article
      Open Access
      Chitosan is a biodegradable natural polysaccharide that has been widely studied for regenerative purposes in the central nervous system. In this study we assessed the in vitro glial and neuronal cells response to chitosan ...
    • Directional alignment of MG63 cells on polymer surfaces containing point microstructures 

      Christopher, A Mills; Fernandez, Javier G; Martinez, Elena; Miriam, Funes; Engel López, Elisabeth; Abdelhamid, Errachid; Planell Estany, Josep Anton; Samitier Martí, Josep (2007-05)
      Article
      Open Access
      MG63 cells cultured on regular arrays of point microstructures (posts and holes) are shown to preferentially align at certain angles to the pattern of the structures, at 08, 308, and 458 in particular. The effect is found ...
    • Disassembling bacterial extracellular matrix with DNase-coated nanoparticles to enhance antibiotic delivery in biofilm infections 

      Baelo, Aida; Levato, Riccardo; Julian, Esther; Crespo, A.; Astola, Jose; Gavalda, Joan; Engel López, Elisabeth; Mateos Timoneda, Miguel Ángel; Torrents, Eduard (2015-07-10)
      Article
      Open Access
      Covenantee:   Hospital Universitari Vall d'Hebron
      Infections caused by biofilm-forming bacteria are a major threat to hospitalized patients and the main cause of chronic obstructive pulmonary disease and cystic fibrosis. There is an urgent necessity for novel therapeutic ...