Browsing by Author "Barrio Casado, María del"
Now showing items 1-20 of 96
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[60]Fullerene for medicinal purposes, a purity criterion towards regulatory considerations
(Multidisciplinary Digital Publishing Institute (MDPI), 2019-08-01)
Article
Open AccessSince the early nineties countless publications have reported promising medicinal applications for [60]fullerene (C60) related to its unparalleled affinity towards free radicals. Yet, until now no officially approved ... -
A facile approach to hydrophilic oxidized fullerenes and their derivatives as cytotoxic agents and supports for nanobiocatalytic systems
(Nature, 2020-12-01)
Article
Open AccessA facile, environment-friendly, versatile and reproducible approach to the successful oxidation of fullerenes (oxC60) and the formation of highly hydrophilic fullerene derivatives is introduced. This synthesis relies on ... -
A new intermediate polymorph of 1-fluoro-adamantane and its second-order-like transition toward the low temperature phase
(2017-06-07)
Article
Open AccessPhase transitions of 1-fluoro-adamantane have been thoroughly investigated by temperature-resolved second harmonic generation (TR-SHG) and X-ray powder diffraction (XRPD). A new polymorph - an intermediate centrosymmetric ... -
A thermodynamically consistent phase diagram of a trimorphic pharmaceutical, L-tyrosine ethyl ester, based on limited experimental data
(Royal Society of Chemistry (RSC), 2018-08-29)
Article
Open Access -
An integrated view of theiInfluence of temperature, pressure, and humidity on the stability of trimorphic cysteamine hydrochloride
(2015-07-01)
Article
Open AccessUnderstanding the phase behavior of pharmaceuticals is important for dosage form development and regulatory requirements, in particular after the incident with ritonavir. In the present paper, a comprehensive study of the ... -
An order-disorder phase transition in the van der Waals based solvate of C60 and CClBrH2
(2018-04-04)
Article
Open AccessThe co-crystal of C60·2CBrClH2 possesses a monoclinic (C2/m) structure at room temperature with both molecular entities, C60 and CBrClH2, orientationally ordered. At 322 K, it transforms reversibly into a hexagonal (P6/mmm) ... -
Barocaloric and magnetocaloric effects in (MnNiSi)1-x(FeCoGe)x
(2018-01-11)
Article
Open Access -
Barocaloric and magnetocaloric effects in Fe49Rh51
(2014-06-06)
Article
Restricted access - publisher's policyWe report on calorimetry under applied hydrostatic pressure and magnetic field at the antiferromagnetic-ferromagnetic (AFM/FM) transition of Fe49Rh51. Results demonstrate the existence of a giant barocaloric effect in this ... -
Benzocaine polymorphism: Pressure-temperature phase diagram involving forms II and III
(2013-11-18)
Article
Restricted access - publisher's policytUnderstanding the phase behavior of an active pharmaceutical ingredient in a drug formulation isrequired to avoid the occurrence of sudden phase changes resulting in decrease of bioavailability in amarketed product. ... -
C60 solvate with (1,1,2)-trichloroethane: dynamic statistical disorder and mixed conformation
(2016-05-27)
Article
Open AccessWe present a full characterization of the orientationally disordered cocrystal of C-60 with (1,1,2)-triChloroethane (C2H3Cl3), by means of X-ray diffraction, Raman spectroscopy, and broadband dielectric spectroscopy. Our ... -
Colossal barocaloric effects near room temperature in plastic crystals of neopentylglycol
(2019-04-18)
Article
Open AccessThere is currently great interest in replacing the harmful volatile hydrofluorocarbon fluids used in refrigeration and air-conditioning with solid materials that display magnetocaloric, electrocaloric or mechanocaloric ... -
Colossal reversible barocaloric effects in layered hybrid perovskite (C10H21NH3)2MnCl4 under low pressure near room temperature
(2021-11-10)
Article
Open AccessBarocaloric effects in a layered hybrid organic–inorganic compound, (C10H21NH3)2MnCl4, that are reversible and colossal under pressure changes below 0.1 GPa are reported. This barocaloric performance originates in a phase ... -
Comparative physical study of three pharmaceutically active benzodiazepine derivatives: crystalline versus amorphous state and crystallization tendency
(American Chemical Society, 2021-01-01)
Article
Restricted access - publisher's policyChemical derivatization and amorphization are two possible strategies to improve the solubility and bioavailability of drugs, which is a key issue for the pharmaceutical industry. In this contribution, we explore whether ... -
Conformational polymorphism: The missing phase of 1,1,2,2-tetrachloroethane (Cl2HC-CHCl2)
(2013-05)
Article
Restricted access - publisher's policyHalogenoethane derivatives are known to exhibit different polymorphs involving a different translational, orientational, and conformational order. The 1,1,2,2- tetrachloroethane (Cl2HC−CHCl2) exhibits a normal pressure ... -
Crystal structure and solid-state properties of 3,4-diaminopyridine dihydrogen phosphate and their comparison with other diaminopyridine salts
(2013-02)
Article
Restricted access - publisher's policy3,4-Diaminopyridine is an active pharmaceutical ingredient for the treatment of Lambert−Eaton myasthenic syndrome (LEMS). It is 3,4-diaminopyridine dihydrogen phosphate that has become the active ingredient of choice. As ... -
Crystal structure and solid-state studies of aged samples of tienoxolol, an API designed against hypertension
(2012)
Article
Restricted access - publisher's policyAging of drug molecules is generally studied following regulatory procedures, i.e. under forced conditions and for relatively limited storage time; therefore naturally aged samples are rare and provide scientific reference ... -
Crystal structure of polymorph II and the pressure-temperature phase diagram of the dimorphic anesthetic butamben
(American Chemical Society, 2021-11-18)
Article
Restricted access - publisher's policyThe crystal structure of the low-temperature form II of butamben has been solved in a P21/c space group very similar to that of form I. Form II possesses virtually the same packing as that of the high-temperature form I, ... -
Crystal structures and phase relationships of 2 polymorphs of 1,4-Diazabicyclo[3.2.2]nonane-4-Carboxylic Acid 4-Bromophenyl Ester Fumarate, A selective a-7 nicotinic receptor partial agonist
(2016-01)
Article
Open AccessTwo polymorphs of the 1:1 fumarate salt of 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester, developed for the treatment of cognitive symptoms of schizophrenia and Alzheimer disease, have been characterized. ... -
Crystalline tetrazepam as a case study on the volume change on melting of molecular organic compounds
(2021-01-25)
Article
Open AccessThe volume change on melting is a rarely studied quantity and it is not well understood even if it must reflect the changes in interaction between the solid and the liquid state. It is part of the solid-state information ... -
Disentangling the secondary relaxations in the orientationally disordered mixed crystals: cycloheptanol + cyclooctanol two-component system
(2010-04-20)
Article
Restricted access - publisher's policyThe dynamics of the pure compounds and mixed crystals formed between cycloheptanol (cC7-ol) and cyclooctanol (cC8-ol) has been studied by means of broadband dielectric spectroscopy at temperatures near and above the ...
