Browsing by Author "Barrio Casado, María del"
Now showing items 1-20 of 70
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A new intermediate polymorph of 1-fluoro-adamantane and its second-order-like transition toward the low temperature phase
(2017-06-07)
Article
Open AccessPhase transitions of 1-fluoro-adamantane have been thoroughly investigated by temperature-resolved second harmonic generation (TR-SHG) and X-ray powder diffraction (XRPD). A new polymorph - an intermediate centrosymmetric ... -
An integrated view of theiInfluence of temperature, pressure, and humidity on the stability of trimorphic cysteamine hydrochloride
(2015-07-01)
Article
Open AccessUnderstanding the phase behavior of pharmaceuticals is important for dosage form development and regulatory requirements, in particular after the incident with ritonavir. In the present paper, a comprehensive study of the ... -
An order-disorder phase transition in the van der Waals based solvate of C60 and CClBrH2
(2018-04-04)
Article
Open AccessThe co-crystal of C60·2CBrClH2 possesses a monoclinic (C2/m) structure at room temperature with both molecular entities, C60 and CBrClH2, orientationally ordered. At 322 K, it transforms reversibly into a hexagonal (P6/mmm) ... -
A thermodynamically consistent phase diagram of a trimorphic pharmaceutical, L-tyrosine ethyl ester, based on limited experimental data
(Royal Society of Chemistry (RSC), 2018-08-29)
Article
Restricted access - publisher's policy -
Barocaloric and magnetocaloric effects in Fe49Rh51
(2014-06-06)
Article
Restricted access - publisher's policyWe report on calorimetry under applied hydrostatic pressure and magnetic field at the antiferromagnetic-ferromagnetic (AFM/FM) transition of Fe49Rh51. Results demonstrate the existence of a giant barocaloric effect in this ... -
Barocaloric and magnetocaloric effects in (MnNiSi)1-x(FeCoGe)x
(2018-01-11)
Article
Open Access -
Benzocaine polymorphism: Pressure-temperature phase diagram involving forms II and III
(2013-11-18)
Article
Restricted access - publisher's policytUnderstanding the phase behavior of an active pharmaceutical ingredient in a drug formulation isrequired to avoid the occurrence of sudden phase changes resulting in decrease of bioavailability in amarketed product. ... -
C60 solvate with (1,1,2)-trichloroethane: dynamic statistical disorder and mixed conformation
(2016-05-27)
Article
Open AccessWe present a full characterization of the orientationally disordered cocrystal of C-60 with (1,1,2)-triChloroethane (C2H3Cl3), by means of X-ray diffraction, Raman spectroscopy, and broadband dielectric spectroscopy. Our ... -
Conformational polymorphism: The missing phase of 1,1,2,2-tetrachloroethane (Cl2HC-CHCl2)
(2013-05)
Article
Restricted access - publisher's policyHalogenoethane derivatives are known to exhibit different polymorphs involving a different translational, orientational, and conformational order. The 1,1,2,2- tetrachloroethane (Cl2HC−CHCl2) exhibits a normal pressure ... -
Crystal structure and solid-state properties of 3,4-diaminopyridine dihydrogen phosphate and their comparison with other diaminopyridine salts
(2013-02)
Article
Restricted access - publisher's policy3,4-Diaminopyridine is an active pharmaceutical ingredient for the treatment of Lambert−Eaton myasthenic syndrome (LEMS). It is 3,4-diaminopyridine dihydrogen phosphate that has become the active ingredient of choice. As ... -
Crystal structure and solid-state studies of aged samples of tienoxolol, an API designed against hypertension
(2012)
Article
Restricted access - publisher's policyAging of drug molecules is generally studied following regulatory procedures, i.e. under forced conditions and for relatively limited storage time; therefore naturally aged samples are rare and provide scientific reference ... -
Crystal structures and phase relationships of 2 polymorphs of 1,4-Diazabicyclo[3.2.2]nonane-4-Carboxylic Acid 4-Bromophenyl Ester Fumarate, A selective a-7 nicotinic receptor partial agonist
(2016-01)
Article
Open AccessTwo polymorphs of the 1:1 fumarate salt of 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester, developed for the treatment of cognitive symptoms of schizophrenia and Alzheimer disease, have been characterized. ... -
Disentangling the secondary relaxations in the orientationally disordered mixed crystals: cycloheptanol + cyclooctanol two-component system
(2010-04-20)
Article
Restricted access - publisher's policyThe dynamics of the pure compounds and mixed crystals formed between cycloheptanol (cC7-ol) and cyclooctanol (cC8-ol) has been studied by means of broadband dielectric spectroscopy at temperatures near and above the ... -
Double primary relaxation in a highly anisotropic orientational glass-former with low-dimensional disorder
(2016-04-26)
Article
Open AccessThe freezing of the cooperative reorientational motions in orientationally disordered (OD) molecular crystals marks the so-called \glassy" transition, which may be considered a lower-dimensional version of the structural ... -
Dynamics of orientationally disordered mixed crystal sharing Cl-adamantane and CN-adamantane
(2010-01-27)
Article
Restricted access - publisher's policyOrientationally disordered (OD) mixed crystals formed between cyanoadamantane (CN-A) and chloroadamantane (Cl-A) have been thermodynamically characterized by means of thermal analysis and X-ray diffraction. The dynamics ... -
Emergence of glassy-like dynamics in an orientationally ordered phase
(2012-04-04)
Article
Open AccessThe dynamics of a simple rigid pseudoglobular molecule (2-adamantanone) has been studied by means of dielectric spectroscopy and examined under the constraints imposed by the space group of the crystal structure determined ... -
Enantiomer resolution by pressure increase: inferences from experimental and topological results for the binary enantiomer system (R)- and (S)-mandelic acid
(2011-11-02)
Article
Restricted access - publisher's policyIn pharmacy, racemic compounds are often problematic, because generally only one of the enantiomers possesses therapeutic activity and it is often difficult to separate them. Even though this problem is likely as old ... -
Experimental and topological determination of the pressure-temperature phase diagram of morniflumate, a pharmaceutical ingredient with anti-inflammatory properties
(2017-09-01)
Article
Open AccessThe pressure-temperature phase diagram of morniflumate (niflumic acid ß-morpholinoethyl ester) has been obtained by high-pressure thermal analysis. In addition, calorimetric melting data (TI¿L = (348.1 ± 0.4) K and ¿HI¿L ... -
From figh-temperature orientationally disordered mixed crystals to low-temperature complex formation in the two-component system (CH3)3CBr + Cl3CBr
(2011-02-02)
Article
Restricted access - publisher's policyThe phase diagram of the two-component systems (CH(3))(3)CBr + Cl(3)CBr has been experimentally determined by means of differential scanning calorimetry and X-ray powder diffraction techniques from the low-temperature ... -
Giant barocaloric effects at low pressure in ferrielectric ammonium sulphate
(2015-11-01)
Article
Open AccessCaloric effects are currently under intense study due to the prospect of environment-friendly cooling applications. Most of the research is centred on large magnetocaloric effects and large electrocaloric effects, but the ...
