Browsing by Author "Campos López, Josefina de Lourdes"Més informacióMés informació

Now showing items 1-11 of 11

    • Coiled-coil conformation of a pentamidine-DNA complex 

      Moreno Chicano, Tadeo; Pous, Joan; Subirana Torrent, Juan A.; Campos López, Josefina de Lourdes (2010-03)
      Article
      Restricted access - publisher's policy
      The coiled-coil structure formed by the complex of the DNA duplex d(ATATATATAT)2 with pentamidine is presented. The duplex was found to have a mixed structure containing Watson-Crick and Hoogsteen base pairs. The drug ...

    • Crystal structure of a complex of DNA with one AT-hook of HMGA1 

      Fonfria Subirós, Elsa; Acosta Reyes, Francisco Javier; Saperas Plana, Núria; Pous, Joan; Subirana Torrent, Juan A.; Campos López, Josefina de Lourdes (2012-05-16)
      Article
      Open Access
      We present here for the first time the crystal structure of an AT-hook domain. We show the structure of an AT-hook of the ubiquitous nuclear protein HMGA1, combined with the oligonucleotide d(CGAATTAATTCG)2, which has two ...

    • DNA coiled coil superstructures in oligonucleotide crystals 

      Luchi, Daniela de; Urpí Garriga, Lourdes; Subirana Torrent, Juan A.; Campos López, Josefina de Lourdes (American Chemical Society (ACS), 2011-05-04)
      Article
      Restricted access - publisher's policy
      We present the structure of coiled coils found in two oligonucleotide DNA crystals. The sequences d-(ATATATATAT) and d(CGATATATAT) are used. In the first case several coiled coils with different structures are found. In ...

    • Effect of solvent choice on the self-assembly properties of a diphenylalanine amphiphile stabilized by an ion pair 

      Mayans Tayadella, Enric; Ballano Ballano, María Gema; Sendros, Javier; Font Bardia, Mercè; Campos López, Josefina de Lourdes; Puiggalí Bellalta, Jordi; Cativiela, Carlos; Alemán Llansó, Carlos (2017-07-19)
      Article
      Restricted access - publisher's policy
      A diphenylalanine (FF) amphiphile blocked at the C terminus with a benzyl ester (OBzl) and stabilized at the N terminus with a trifluoroacetate (TFA) anion was synthetized and characterized. Aggregation of peptide molecules ...

    • Functional and structural analysis of AT-specific minor groove binders that disrupt DNA-protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast 

      Millán Elías, Cinthia Raquel; Acosta Reyes, Francisco Javier; Lagartera, Laura; Ebiloma, Godwin U.; Lemgruber, Leandro; Nué Martinez, J. Jonathan; Saperas Plana, Núria; Dardonville, Cristophe; De Koning, Harry Pieter; Campos López, Josefina de Lourdes (2017-08-21)
      Article
      Open Access
      Trypanosoma brucei, the causative agent of sleeping sickness (Human African Trypanosomiasis, HAT), contains a kinetoplast with the mitochondrial DNA (kDNA), comprising of >70% AT base pairs. This has prompted studies of ...

    • In and out of the minor groove: Interaction of an AT-rich DNA with the drug CD27 

      Acosta Reyes, Francisco Javier; Dardonville, Cristophe Y.; De Koning, Harry Pieter; Natto, Manal J.; Subirana, Juan Antonio; Campos López, Josefina de Lourdes (2014-06)
      Article
      Open Access
      The DNA of several pathogens is very rich in AT base pairs. Typical examples include the malaria parasite Plasmodium falciparum and the causative agents of trichomoniasis and trypanosomiases. This fact has prompted studies ...

    • Journal of Materials Chemistry C 

      El-Hachemi, Zoubir; Escudero, Carlos; Acosta-Reyes, Francisco; Casas Becerra, María Teresa; Aloni, Shaul; Oncins, Gerard; Sorrenti, Alessandro; Crusats, Joaquim; Ribó Trujillo, Josep M.; Campos López, Josefina de Lourdes (Royal Society of Chemistry, 2013-03-28)
      Article
      Open Access
      The structure of the meso-tetrakis(4-sulfonatophenyl)porphyrin (TPPS4) J-aggregates could be determined by X-ray and electron diffraction methods. A sheet-like architecture reveals the relationship between structure and ...

    • New drugs complexed with AT-rich DNA against neglected diseases 

      Millán, Cinthia; Acosta Reyes, Francisco Javier; Lagartera, Laura; Saperas Plana, Núria; Dardonville, Cristophe; De Koning, Harry Pieter; Campos López, Josefina de Lourdes (2019)
      Conference lecture
      Restricted access - publisher's policy

    • Structure of the DNA duplex d(ATTAAT)(2) with Hoogsteen hydrogen bonds 

      Acosta Reyes, Francisco Javier; Subirana, Juan Antonio; Campos López, Josefina de Lourdes; Alechaga, Elida (2015-03-17)
      Article
      Open Access
      The traditional Watson-Crick base pairs in DNA may occasionally adopt a Hoogsteen conformation, with a different organization of hydrogen bonds. Previous crystal structures have shown that the Hoogsteen conformation is ...

    • The influence of Ni2+ and other ions on the trigonal structure of DNA 

      Acosta Reyes, Francisco Javier; Pagan, Mireia; Fonfría-Subirós, Elsa; Saperas Plana, Núria; Subirana Torrent, Juan A.; Campos López, Josefina de Lourdes (Wiley, 2021-04-13)
      Article
      Open Access
      We present a new structure of a DNA dodecamer obtained in the presence of Ni2+ ions. The DNA forms Ni-guanine cross-links between neighboring molecules. Our results show that an adequate dosage of Ni2+ may help to form ...

    • Two high-mobility group box domains act together to underwind and kink DNA. 

      Sánchez Giraldo, Raquel; Acosta Reyes, Francisco Javier; Malarkey, Christopher S.; Saperas Plana, Núria; Churchill, Mair E. A.; Campos López, Josefina de Lourdes (2015-07-02)
      Article
      Open Access
      High-mobility group protein 1 (HMGB1) is an essential and ubiquitous DNA architectural factor that influences a myriad of cellular processes. HMGB1 contains two DNA-binding domains, box A and box B, which have little ...