Browsing by Author "Langohr, Klaus"
Now showing items 1-20 of 35
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5-HTTLPR polymorphism, mood disorders and MDMA use in a 3-year follow-up study
(2010-01)
Article
Restricted access - publisher's policyA 3-year longitudinal prospective study was conducted to compare the incidence of substance use disorders (SUD) and non-substance use disorders (NSUD) among ecstasy users and two control groups: one of cannabis users and ... -
A lower olfactory capacity Is related to higher circulating concentrations of endocannabinoid 2-arachidonoylglycerol and higher body mass index in women
(2016)
Article
Open AccessThe endocannabinoid (eCB) system can promote food intake by increasing odor detection in mice. The eCB system is over-active in human obesity. Our aim is to measure circulating eCB concentrations and olfactory capacity in ... -
A new cognitive evaluation battery for Down syndrome and its relevance for clinical trials
(2015-06-04)
Article
Open AccessThe recent prospect of pharmaceutical interventions for cognitive impairment of Down syndrome (DS) has boosted a number of clinical trials in this population. However, running the trials has raised some methodological ... -
Clinical Pharmacology of 3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy''): the influence of gender and genetics (CYP2D6, COMT, 5-HTT)
(2012-10-24)
Article
Open AccessThe synthetic psychostimulant MDMA (63,4-methylenedioxymethamphetamine, ecstasy) acts as an indirect serotonin, dopamine, and norepinephrine agonist and as a mechanism-based inhibitor of the cytochrome P-450 2D6 (CYP2D6). ... -
Combined treatment with environmental enrichment and (-)-epigallocatechin-3-gallate ameliorates learning deficits and hippocampal alterations in a mouse model of Down Syndrome
(2016-11-08)
Article
Open AccessIntellectual disability in Down syndrome (DS) is accompanied by altered neuro-architecture, deficient synaptic plasticity, and excitation-inhibition imbalance in critical brain regions for learning and memory. Recently, ... -
Deep sclerectomy with supraciliary hema implant (Esnoper (R) V-2000): results and complications
(2015-10-01)
Article
Open AccessThe aim was to report the results of deep sclerectomy (DS) with supraciliary hema implant and the influence of the surgical complications on intraocular pressure (IOP). Forty-eight eyes of 41 patients with open angle ... -
Effect of physical fitness and endurance exercise on indirect biomarkers of growth hormone and insulin misuse: immunoassay-based measurement in urine samples
(2010)
Article
Restricted access - publisher's policyIndirect biomarkers of recombinant human growth hormone (rhGH), insulin-like growth factor-I (IGF-I), insulin-like growth factor-II (IGF-II), insulin-like growth factor binding proteins (IGFBP-2 and IGFBP-3) and insulin ... -
Ethanol induces hydroxytyrosol formation in humans
(2015)
Article
Open AccessPrevious studies in animals have shown an increase of hydroxytyrosol (OHTyr), a potent phenolic antioxidant and a minor metabolite of dopamine (also called 3,4-dihydroxyphenylethanol or DOPET), after ethanol intake. The ... -
Factors associated with discharge against medical advice from an alcohol and drug inpatient detoxifcation unit in Barcelona between 1993 and 2006
(2012)
Article
Open AccessRecords from 1,228 consecutively admitted patients (74.5% male) to an inpatient detoxification unit in Barcelona between 1993 and 2006 were examined to determine factors associated with discharge against medical advice ... -
FHtest: an R package for the comparison of survival curves with censored data
(2017-11)
Article
Open AccessThe Fleming-Harrington class for right-censored data was first introduced by Harrington and Fleming (1982). This class is widely used in survival analysis studies and it is a subset of the so-called weighted logrank test ... -
Glucocorticoid receptors, brain-derived neurotrophic factor, serotonin and dopamine neurotransmission are associated with interferon-induced depression
(2016-12-30)
Article
Open AccessBackground: The role of inflammation in mood disorders has received increased attention. There is substantial evidence that cytokine therapies, such as interferon alpha (IFN-alpha), can induce depressive symptoms. Indeed, ... -
High risk and probability of progression to osteoporosis at 10 years in HIV-infected individuals: the role of PIs
(2018-09-01)
Article
Restricted access - publisher's policy -
Importancia de la potencia y la hipótesis en el valor p
(Elsevier, 2015-12-09)
Article
Open AccessLos lectores de Medicina Clínica conocen bien la importancia de definir bien el denominador de una proporción para estimar una probabilidad: “No es lo mismo la probabilidad de que un católico sea Papa que la de que un Papa ... -
Incidence of infectious diseases and survival among the Roma population: a longitudinal cohort study
(Oxford University Press, 2011-01-07)
Article
Open AccessBackground: Roma ethnicity is greatly affected by tuberculosis (TB), AIDS, injecting drugs use (IDU) and imprisonment. Methods: We assessed the incidence of several health problems by means of a retrospective cohort study ... -
Incidence of injuries in competition of Leonese wrestling and associated factors (2005–2015) Incidencia de lesiones en la competición de Lucha Leonesa y Factores Asociados (2005-2015)
(2018-09)
Article
Restricted access - publisher's policyIntroducción: La lucha tradicional es considerada un patrimonio cultural de la humanidad que debe protegerse. El estudio de las lesiones y sus factores asociados puede favorecer la protección de este patrimonio. El presente ... -
Lesiones en la lucha tradicional: el caso de la lucha leonesa (2005-2015)
(2018-12-01)
Article
Open AccessEl objetivo de este estudio fue describir la localización anatómica, el tipo y la gravedad de las lesiones ocurridas en las competiciones oficiales de las ligas de verano masculinas (2005-2015) de Lucha Leonesa. Al objeto ... -
Multiple imputation approach for interval-censored time to HIV RNA viral rebound within a mixed effects Cox model
(2018-01-01)
Article
Open AccessWe present a method to fit a mixed effects Cox model with interval-censored data. Our proposal is based on a multiple imputation approach that uses the truncated Weibull distribution to replace the interval-censored data ... -
Non-linear formation of EtG and FAEEs after controlled administration of low to moderate doses of ethanol
(2017-09-01)
Article
Open AccessAims Ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEEs) are non-oxidative metabolites of alcohol that can be detected in conventional and non-conventional biological matrices for longer periods than alcohol. The ... -
Parameter estimation of Poisson generalized linear mixed models based on three different statistical principles: a simulation study
(Institut d'Estadística de Catalunya, 2015-12)
Article
Open AccessGeneralized linear mixed models are flexible tools for modeling non-normal data and are useful for accommodating overdispersion in Poisson regression models with random effects. Their main difficulty resides in the parameter ... -
Parameter estimation of Poisson generalized linear mixed models based on three different statistical principles: a simulation study
(Institut d'Estadística de Catalunya, 2015-12)
Article
Open AccessGeneralized linear mixed models are flexible tools for modeling non-normal data and are usefulfor accommodating overdispersion in Poisson regression models with random effects. Theirmain difficulty resides in the parameter ...
