Browsing by Author "Castaño Linares, Óscar"
Now showing items 1-19 of 19
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A novel hybrid nanofibrous strategy to target progenitor cells for cost-effective in situ angiogenesis
Sachot, Nadège; Castaño Linares, Óscar; Oliveira, Hugo; Martí Muñoz, Joan; Roguska, Agata; Amedee, Joelle; Lewandowska, Malgorzata; Planell Estany, Josep Anton; Engel López, Elisabeth (Royal Society of Chemistry, 2016-11-02)
Article
Open AccessAlthough the impact of composites based on Ti-doped calcium phosphate glasses is low compared with that of bioglass, they have been already shown to possess great potential for bone tissue engineering. Composites made of ... -
A novel hybrid nanofibrous strategy to target progenitor cells for cost-effective: In situ angiogenesis
Sachot, Nadege; Castaño Linares, Óscar; Oliveira, Hugo; Martí Muñoz, Joan; Roguska, Agata; Amedee, Joelle; Lewandowska, Malgorzata; Planell Estany, Josep Anton; Engel López, Elisabeth (Royal Society of Chemistry, 2016-09-22)
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Open AccessAlthough the impact of composites based on Ti-doped calcium phosphate glasses is low compared with that of bioglass, they have been already shown to possess great potential for bone tissue engineering. Composites made of ... -
Angiogenesis in bone regeneration: tailored calcium release in hybrid fibrous scaffolds
Castaño Linares, Óscar; Sachot, Nadège; Xuriguera Martin, Elena; Engel López, Elisabeth; Planell Estany, Josep Anton; Park, Jaegyun; Jin, Guang-Zhen; Kim, Tae-Hyun; Kim, Joong-Hyun; Kim, Hae-Won (2014-05-28)
Article
Restricted access - publisher's policy
Covenantee: Tan'guk TaehakkyoIn bone regeneration, silicon-based calcium phosphate glasses (Bioglasses) have been widely used since the 1970s. However, they dissolve very slowly because of their high amount of Si (SiO2 > 45%). Recently, our group has ... -
Control of microenvironmental cues with a smart biomaterial composite promotes endothelial progenitor cell angiogenesis
Aguirre, Adrián; Gonzalez, Arlyng; Navarro, Melba; Castaño Linares, Óscar; Planell Estany, Josep Anton; Engel López, Elisabeth (2012-09)
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Open AccessSmart biomaterials play a key role when aiming at successful tissue repair by means of regenerative medicine approaches, and are expected to contain chemical as well as mechanical cues that will guide the regenerative ... -
Development of a novel automatable fabrication method based on electrospinning co electrospraying for rotator cuff augmentation patches
Rey Viñoles, Sergi; Castaño Linares, Óscar; Ruiz Macarrilla, Leonardo; Llorens, Xavier; Mora Guix, José M.; Engel López, Elisabeth; Mateos Timoneda, Miguel Ángel (Public Library of Science (PLOS), 2019-01-01)
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Open AccessRotator cuff tear is one of the most common shoulder diseases. Rotator cuff augmentation (RCA) is trying to solve the high retear failure percentage after the surgery procedures (20–90%). The ideal augmentation patch must ... -
Effect of structure, topography and chemistry on fibroblast adhesion and morphology
Mateos Timoneda, Miguel Ángel; Castaño Linares, Óscar; Planell Estany, Josep Anton; Engel López, Elisabeth (2014-07)
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Restricted access - publisher's policySurface biofunctionalisation of many biodegradable polymers is one of the used strategies to improve the biological activity of such materials. In this work, the introduction of collagen type I over the surface of a ... -
Electrospun gelatin/poly(epsilon-caprolactone) fibrous scaffold modified with calcium phosphate for bone tissue engineering
Rajzer, Izabella; Menaszek, Elzbieta; Kwiatkowski, Ryszard; Castaño Linares, Óscar; Planell Estany, Josep Anton (2014-11-01)
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Restricted access - publisher's policyIn this study gelatin (Gel) modified with calcium phosphate nanoparticles (SG5) and polycaprolactone (PCL) were used to prepare a 3D bi-layer scaffold by collecting electrospun PCL and gelatin/SG5 fibers separately in the ... -
Fast-degrading PLA/ORMOGLASS fibrous composite scaffold leads to a calcium-rich angiogenic environment
Sachot, Nadège; Roguska, Agata; Planell Estany, Josep Anton; Lewandowska, Malgorzata; Engel López, Elisabeth; Castaño Linares, Óscar (2017-01-01)
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Open AccessThe success of scaffold implantation in acellular tissue engineering approaches relies on the ability of the material to interact properly with the biological environment. This behavior mainly depends on the design of the ... -
Feasible and pure P2O5-CaO nanoglasses: An in-depth NMR study of synthesis for the modulation of the bioactive ion release
Martí Muñoz, Joan; Xuriguera Martin, Elena; Layton, John W.; Planell Estany, Josep Anton; Rankin, Stephen E.; Engel López, Elisabeth; Castaño Linares, Óscar (Elsevier, 2019-01-01)
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Restricted access - publisher's policyThe use of bioactive glasses (e.g. silicates, phosphates, borates) has demonstrated to be an effective therapy for the restoration of bone fractures, wound healing and vascularization. Their partial dissolution towards the ... -
Hierarchically engineered fibrous scaffolds for bone regeneration
Sachot, Nadège; Castaño Linares, Óscar; Mateos Timoneda, Miguel Ángel; Engel López, Elisabeth; Planell Estany, Josep Anton (2013-08-28)
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Open AccessSurface properties of biomaterials play a major role in the governing of cell functionalities. It is well known that mechanical, chemical and nanotopo- graphic cues, for example, influence cell proliferation and ... -
Injectable and fast resorbable calcium phosphate cement for body-setting bone grafts
Rajzer, I.; Castaño Linares, Óscar; Engel López, Elisabeth; Planell Estany, Josep Anton (2010)
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Restricted access - publisher's policy -
Modular bioink for 3D printing of biocompatible hydrogels: sol-gel polymerization of hybrid peptides and polymers
Echalier, Cecile; Levato, Riccardo; Mateos Timoneda, Miguel Ángel; Castaño Linares, Óscar; Dejean, S; Garric, X; Pinese, C; Noël, D; Engel López, Elisabeth; Martinez, J; Mehdi, A; Subra, Gilles (Royal Society of Chemistry, 2017-02-21)
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Open AccessAn unprecedented generic system allowing the 3D printing of peptide-functionalized hydrogels by soft sol–gel inorganic polymerization is presented. Hybrid silylated inorganic/bioorganic blocks are mixed in biological buffer ... -
Neurogenesis and vascularization of the damaged brain using a lactate-releasing biomimetic scaffold
Álvarez Pinto, Zaída; Castaño Linares, Óscar; Castells, Alba; Mateos Timoneda, Miguel Ángel; Planell Estany, Josep Anton; Engel López, Elisabeth; Alcántara, Soledad (2014-06)
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Restricted access - publisher's policyRegenerative medicine strategies to promote recovery following traumatic brain injuries are currently focused on the use of biomaterials as delivery systems for cells or bioactive molecules. This study shows that cell-free ... -
Optimization of blend parameters for the fabrication of polycaprolactone-silicon based ormoglass nanofibers by electrospinning
Sachot, Nadège; Castaño Linares, Óscar; Planell Estany, Josep Anton; Engel López, Elisabeth (2015-08-01)
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Open AccessElectrospinning is a method that can be used to efficiently produce scaffolds that mimic the fibrous structure of natural tissue, such as muscle structures or the extracellular matrix of bone. The technique is often used ... -
PEG hydrogel containing calcium-releasing particles and mesenchymal stromal cells promote vessel maturation
Navarro Requena, Claudia; Weaver, Jessica D.; Clark, Amy Y.; Clift, Douglas; Pérez Amodio, Soledad Graciela; Castaño Linares, Óscar; Zhou, Dennis W.; García, Andrés J.; Engel López, Elisabeth (2018-02)
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Restricted access - publisher's policyThe use of human mesenchymal stromal cells (hMSC) for treating diseased tissues with poor vascularization has received significant attention, but low cell survival has hampered its translation to the clinic. Bioglasses and ... -
The effect of the composition of PLA films and lactate release on glial and neuronal maturation and the maintenance of the neuronal progenitor niche.
Álvarez, Zaída; Mateos Timoneda, Miguel Ángel; Hyroššová, Petra Hyroššová; Castaño Linares, Óscar; Planell Estany, Josep Anton; Perales, José C.; Engel López, Elisabeth; Alcántara, Soledad (2013-03-06)
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Restricted access - publisher's policyTo develop tissue engineering strategies useful for repairing damage in the central nervous system (CNS) it is essential to design scaffolds that emulate the NSC niche and its tight control of neural cell genesis, growth, ... -
The proangiogenic potential of a novel calcium releasing biomaterial: Impact on cell recruitment
Oliveira, Hugo; Catros, Sylvain; Boiziau, Claudine; Siadous, Robin; Martí Muñoz, Joan; Bareille, Reine; Rey, Sylvie; Castaño Linares, Óscar; Planell Estany, Josep Anton; Amedee, Joelle; Engel López, Elisabeth (2016-01-01)
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Open AccessIn current bone tissue engineering strategies the achievement of sufficient angiogenesis during tissue regeneration is still a major limitation in order to attain full functionality. Several strategies have been described ... -
The proangiogenic potential of a novel calcium releasing composite biomaterial: Orthotopic in vivo evaluation
Oliveira, Hugo; Catros, Sylvain; Castaño Linares, Óscar; Rey, Sylvie; Siadous, Robin; Clift, Douglas; Martí Muñoz, Joan; Batista, Marc; Bareille, Reine; Planell Estany, Josep Anton; Engel López, Elisabeth; Amedee, Joelle (2017-05-01)
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Open AccessInsufficient angiogenesis remains a major hurdle in current bone tissue engineering strategies. An extensive body of work has focused on the use of angiogenic factors or endothelial progenitor cells. However, these approaches ... -
Towards 4th generation biomaterials: a covalent hybrid polymer-ormoglass architecture
Sachot, Nadège; Mateos Timoneda, Miguel Ángel; Planell Estany, Josep Anton; Velders, A. H.; lewandowska, M.; Engel López, Elisabeth; Castaño Linares, Óscar (2015-01-01)
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Open AccessHybrid materials are being extensively investigated with the aim of mimicking the ECM microenvironment to develop effective solutions for bone tissue engineering. However, the common drawbacks of a hybrid material are the ...