Browsing by Author "Castaño Linares, Óscar"
Now showing items 1-20 of 23
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A microphysiological system combining electrospun fibers and electrical stimulation for the maturation of highly anisotropic cardiac tissue
(2021-06-01)
Article
Open Accesshe creation of cardiac tissue models for preclinical testing is still a non-solved problem in drug discovery, due to the limitations related to the in vitro replication of cardiac tissue complexity. Among these limitations, ... -
A novel hybrid nanofibrous strategy to target progenitor cells for cost-effective in situ angiogenesis
(Royal Society of Chemistry, 2016-11-02)
Article
Open AccessAlthough the impact of composites based on Ti-doped calcium phosphate glasses is low compared with that of bioglass, they have been already shown to possess great potential for bone tissue engineering. Composites made of ... -
A novel hybrid nanofibrous strategy to target progenitor cells for cost-effective: In situ angiogenesis
(Royal Society of Chemistry, 2016-09-22)
Article
Open AccessAlthough the impact of composites based on Ti-doped calcium phosphate glasses is low compared with that of bioglass, they have been already shown to possess great potential for bone tissue engineering. Composites made of ... -
Angiogenesis in bone regeneration: tailored calcium release in hybrid fibrous scaffolds
(2014-05-28)
Article
Restricted access - publisher's policy
Covenantee: Tan'guk TaehakkyoIn bone regeneration, silicon-based calcium phosphate glasses (Bioglasses) have been widely used since the 1970s. However, they dissolve very slowly because of their high amount of Si (SiO2 > 45%). Recently, our group has ... -
Chemotactic TEG3 cells’ guiding platforms based on PLA fibers functionalized with the SDF-1a/CXCL12 chemokine for neural regeneration therapy
(Frontiers Media SA, 2021-03-22)
Article
Open Access(Following spinal cord injury, olfactory ensheathing cell (OEC) transplantation is a promising therapeutic approach in promoting functional improvement. Some studies report that the migratory properties of OECs are compromised ... -
Control of microenvironmental cues with a smart biomaterial composite promotes endothelial progenitor cell angiogenesis
(2012-09)
Article
Open AccessSmart biomaterials play a key role when aiming at successful tissue repair by means of regenerative medicine approaches, and are expected to contain chemical as well as mechanical cues that will guide the regenerative ... -
Development of a novel automatable fabrication method based on electrospinning co electrospraying for rotator cuff augmentation patches
(Public Library of Science (PLOS), 2019-01-01)
Article
Open AccessRotator cuff tear is one of the most common shoulder diseases. Rotator cuff augmentation (RCA) is trying to solve the high retear failure percentage after the surgery procedures (20–90%). The ideal augmentation patch must ... -
Effect of structure, topography and chemistry on fibroblast adhesion and morphology
(2014-07)
Article
Restricted access - publisher's policySurface biofunctionalisation of many biodegradable polymers is one of the used strategies to improve the biological activity of such materials. In this work, the introduction of collagen type I over the surface of a ... -
Electrospun gelatin/poly(epsilon-caprolactone) fibrous scaffold modified with calcium phosphate for bone tissue engineering
(2014-11-01)
Article
Restricted access - publisher's policyIn this study gelatin (Gel) modified with calcium phosphate nanoparticles (SG5) and polycaprolactone (PCL) were used to prepare a 3D bi-layer scaffold by collecting electrospun PCL and gelatin/SG5 fibers separately in the ... -
Engineering cell-derived matrices: from 3D models to advanced personalized therapies
(2020-07-02)
Article
Open AccessRegenerative medicine and disease models have evolved in recent years from two to three dimensions, providing in vitro constructs that are more similar to in vivo tissues. By mimicking native tissues, cell-derived matrices ... -
Fast-degrading PLA/ORMOGLASS fibrous composite scaffold leads to a calcium-rich angiogenic environment
(2017-01-01)
Article
Open AccessThe success of scaffold implantation in acellular tissue engineering approaches relies on the ability of the material to interact properly with the biological environment. This behavior mainly depends on the design of the ... -
Feasible and pure P2O5-CaO nanoglasses: An in-depth NMR study of synthesis for the modulation of the bioactive ion release
(Elsevier, 2019-01-01)
Article
Open AccessThe use of bioactive glasses (e.g. silicates, phosphates, borates) has demonstrated to be an effective therapy for the restoration of bone fractures, wound healing and vascularization. Their partial dissolution towards the ... -
Hierarchically engineered fibrous scaffolds for bone regeneration
(2013-08-28)
Article
Open AccessSurface properties of biomaterials play a major role in the governing of cell functionalities. It is well known that mechanical, chemical and nanotopo- graphic cues, for example, influence cell proliferation and ... -
In vitro evaluation of degradable electrospun polylactic acid/bioactive calcium phosphate ormoglass scaffolds
(2020-04-24)
Article
Open AccessNowadays, the main limitation for clinical application of scaffolds is considered to be an insufficient vascularization of the implanted platforms and healing tissues. In our studies, we proposed a novel PLA-based hybrid ... -
Injectable and fast resorbable calcium phosphate cement for body-setting bone grafts
(2010)
Article
Restricted access - publisher's policy -
Modular bioink for 3D printing of biocompatible hydrogels: sol-gel polymerization of hybrid peptides and polymers
(Royal Society of Chemistry, 2017-02-21)
Article
Open AccessAn unprecedented generic system allowing the 3D printing of peptide-functionalized hydrogels by soft sol–gel inorganic polymerization is presented. Hybrid silylated inorganic/bioorganic blocks are mixed in biological buffer ... -
Neurogenesis and vascularization of the damaged brain using a lactate-releasing biomimetic scaffold
(2014-06)
Article
Restricted access - publisher's policyRegenerative medicine strategies to promote recovery following traumatic brain injuries are currently focused on the use of biomaterials as delivery systems for cells or bioactive molecules. This study shows that cell-free ... -
Optimization of blend parameters for the fabrication of polycaprolactone-silicon based ormoglass nanofibers by electrospinning
(2015-08-01)
Article
Open AccessElectrospinning is a method that can be used to efficiently produce scaffolds that mimic the fibrous structure of natural tissue, such as muscle structures or the extracellular matrix of bone. The technique is often used ... -
PEG hydrogel containing calcium-releasing particles and mesenchymal stromal cells promote vessel maturation
(2018-02)
Article
Restricted access - publisher's policyThe use of human mesenchymal stromal cells (hMSC) for treating diseased tissues with poor vascularization has received significant attention, but low cell survival has hampered its translation to the clinic. Bioglasses and ... -
The effect of the composition of PLA films and lactate release on glial and neuronal maturation and the maintenance of the neuronal progenitor niche.
(2013-03-06)
Article
Restricted access - publisher's policyTo develop tissue engineering strategies useful for repairing damage in the central nervous system (CNS) it is essential to design scaffolds that emulate the NSC niche and its tight control of neural cell genesis, growth, ...
