Now showing items 1-20 of 20

    • A novel hybrid nanofibrous strategy to target progenitor cells for cost-effective in situ angiogenesis 

      Sachot, Nadège; Castaño Linares, Óscar; Oliveira, Hugo; Martí Muñoz, Joan; Roguska, Agata; Amedee, Joelle; Lewandowska, Malgorzata; Planell Estany, Josep Anton; Engel López, Elisabeth (Royal Society of Chemistry, 2016-11-02)
      Article
      Open Access
      Although the impact of composites based on Ti-doped calcium phosphate glasses is low compared with that of bioglass, they have been already shown to possess great potential for bone tissue engineering. Composites made of ...
    • A novel hybrid nanofibrous strategy to target progenitor cells for cost-effective: In situ angiogenesis 

      Sachot, Nadege; Castaño Linares, Óscar; Oliveira, Hugo; Martí Muñoz, Joan; Roguska, Agata; Amedee, Joelle; Lewandowska, Malgorzata; Planell Estany, Josep Anton; Engel López, Elisabeth (Royal Society of Chemistry, 2016-09-22)
      Article
      Open Access
      Although the impact of composites based on Ti-doped calcium phosphate glasses is low compared with that of bioglass, they have been already shown to possess great potential for bone tissue engineering. Composites made of ...
    • Angiogenesis in bone regeneration: tailored calcium release in hybrid fibrous scaffolds 

      Castaño Linares, Óscar; Sachot, Nadège; Xuriguera Martin, Elena; Engel López, Elisabeth; Planell Estany, Josep Anton; Park, Jaegyun; Jin, Guang-Zhen; Kim, Tae-Hyun; Kim, Joong-Hyun; Kim, Hae-Won (2014-05-28)
      Article
      Restricted access - publisher's policy
      Covenantee:   Tan'guk Taehakkyo
      In bone regeneration, silicon-based calcium phosphate glasses (Bioglasses) have been widely used since the 1970s. However, they dissolve very slowly because of their high amount of Si (SiO2 > 45%). Recently, our group has ...
    • Control of microenvironmental cues with a smart biomaterial composite promotes endothelial progenitor cell angiogenesis 

      Aguirre, Adrián; Gonzalez, Arlyng; Navarro, Melba; Castaño Linares, Óscar; Planell Estany, Josep Anton; Engel López, Elisabeth (2012-09)
      Article
      Open Access
      Smart biomaterials play a key role when aiming at successful tissue repair by means of regenerative medicine approaches, and are expected to contain chemical as well as mechanical cues that will guide the regenerative ...
    • Development of a novel automatable fabrication method based on electrospinning co electrospraying for rotator cuff augmentation patches 

      Rey Viñoles, Sergi; Castaño Linares, Óscar; Ruiz Macarrilla, Leonardo; Llorens, Xavier; Mora Guix, José M.; Engel López, Elisabeth; Mateos Timoneda, Miguel Ángel (Public Library of Science (PLOS), 2019-01-01)
      Article
      Open Access
      Rotator cuff tear is one of the most common shoulder diseases. Rotator cuff augmentation (RCA) is trying to solve the high retear failure percentage after the surgery procedures (20–90%). The ideal augmentation patch must ...
    • Effect of structure, topography and chemistry on fibroblast adhesion and morphology 

      Mateos Timoneda, Miguel Ángel; Castaño Linares, Óscar; Planell Estany, Josep Anton; Engel López, Elisabeth (2014-07)
      Article
      Restricted access - publisher's policy
      Surface biofunctionalisation of many biodegradable polymers is one of the used strategies to improve the biological activity of such materials. In this work, the introduction of collagen type I over the surface of a ...
    • Electrospun gelatin/poly(epsilon-caprolactone) fibrous scaffold modified with calcium phosphate for bone tissue engineering 

      Rajzer, Izabella; Menaszek, Elzbieta; Kwiatkowski, Ryszard; Castaño Linares, Óscar; Planell Estany, Josep Anton (2014-11-01)
      Article
      Restricted access - publisher's policy
      In this study gelatin (Gel) modified with calcium phosphate nanoparticles (SG5) and polycaprolactone (PCL) were used to prepare a 3D bi-layer scaffold by collecting electrospun PCL and gelatin/SG5 fibers separately in the ...
    • Fast-degrading PLA/ORMOGLASS fibrous composite scaffold leads to a calcium-rich angiogenic environment 

      Sachot, Nadège; Roguska, Agata; Planell Estany, Josep Anton; Lewandowska, Malgorzata; Engel López, Elisabeth; Castaño Linares, Óscar (2017-01-01)
      Article
      Open Access
      The success of scaffold implantation in acellular tissue engineering approaches relies on the ability of the material to interact properly with the biological environment. This behavior mainly depends on the design of the ...
    • Feasible and pure P2O5-CaO nanoglasses: An in-depth NMR study of synthesis for the modulation of the bioactive ion release 

      Martí Muñoz, Joan; Xuriguera Martin, Elena; Layton, John W.; Planell Estany, Josep Anton; Rankin, Stephen E.; Engel López, Elisabeth; Castaño Linares, Óscar (Elsevier, 2019-01-01)
      Article
      Open Access
      The use of bioactive glasses (e.g. silicates, phosphates, borates) has demonstrated to be an effective therapy for the restoration of bone fractures, wound healing and vascularization. Their partial dissolution towards the ...
    • Hierarchically engineered fibrous scaffolds for bone regeneration 

      Sachot, Nadège; Castaño Linares, Óscar; Mateos Timoneda, Miguel Ángel; Engel López, Elisabeth; Planell Estany, Josep Anton (2013-08-28)
      Article
      Open Access
      Surface properties of biomaterials play a major role in the governing of cell functionalities. It is well known that mechanical, chemical and nanotopo- graphic cues, for example, influence cell proliferation and ...
    • In vitro evaluation of degradable electrospun polylactic acid/bioactive calcium phosphate ormoglass scaffolds 

      Majchrowicz, Anna; Roguska, Agata; Krawczynska, A.; Lewandowska, Malgorzata; Martí Muñoz, Joan; Engel López, Elisabeth; Castaño Linares, Óscar (2020-04-24)
      Article
      Open Access
      Nowadays, the main limitation for clinical application of scaffolds is considered to be an insufficient vascularization of the implanted platforms and healing tissues. In our studies, we proposed a novel PLA-based hybrid ...
    • Injectable and fast resorbable calcium phosphate cement for body-setting bone grafts 

      Rajzer, I.; Castaño Linares, Óscar; Engel López, Elisabeth; Planell Estany, Josep Anton (2010)
      Article
      Restricted access - publisher's policy
    • Modular bioink for 3D printing of biocompatible hydrogels: sol-gel polymerization of hybrid peptides and polymers 

      Echalier, Cecile; Levato, Riccardo; Mateos Timoneda, Miguel Ángel; Castaño Linares, Óscar; Dejean, S; Garric, X; Pinese, C; Noël, D; Engel López, Elisabeth; Martinez, J; Mehdi, A; Subra, Gilles (Royal Society of Chemistry, 2017-02-21)
      Article
      Open Access
      An unprecedented generic system allowing the 3D printing of peptide-functionalized hydrogels by soft sol–gel inorganic polymerization is presented. Hybrid silylated inorganic/bioorganic blocks are mixed in biological buffer ...
    • Neurogenesis and vascularization of the damaged brain using a lactate-releasing biomimetic scaffold 

      Álvarez Pinto, Zaída; Castaño Linares, Óscar; Castells, Alba; Mateos Timoneda, Miguel Ángel; Planell Estany, Josep Anton; Engel López, Elisabeth; Alcántara, Soledad (2014-06)
      Article
      Restricted access - publisher's policy
      Regenerative medicine strategies to promote recovery following traumatic brain injuries are currently focused on the use of biomaterials as delivery systems for cells or bioactive molecules. This study shows that cell-free ...
    • Optimization of blend parameters for the fabrication of polycaprolactone-silicon based ormoglass nanofibers by electrospinning 

      Sachot, Nadège; Castaño Linares, Óscar; Planell Estany, Josep Anton; Engel López, Elisabeth (2015-08-01)
      Article
      Open Access
      Electrospinning is a method that can be used to efficiently produce scaffolds that mimic the fibrous structure of natural tissue, such as muscle structures or the extracellular matrix of bone. The technique is often used ...
    • PEG hydrogel containing calcium-releasing particles and mesenchymal stromal cells promote vessel maturation 

      Navarro Requena, Claudia; Weaver, Jessica D.; Clark, Amy Y.; Clift, Douglas; Pérez Amodio, Soledad Graciela; Castaño Linares, Óscar; Zhou, Dennis W.; García, Andrés J.; Engel López, Elisabeth (2018-02)
      Article
      Restricted access - publisher's policy
      The use of human mesenchymal stromal cells (hMSC) for treating diseased tissues with poor vascularization has received significant attention, but low cell survival has hampered its translation to the clinic. Bioglasses and ...
    • The effect of the composition of PLA films and lactate release on glial and neuronal maturation and the maintenance of the neuronal progenitor niche. 

      Álvarez, Zaída; Mateos Timoneda, Miguel Ángel; Hyroššová, Petra Hyroššová; Castaño Linares, Óscar; Planell Estany, Josep Anton; Perales, José C.; Engel López, Elisabeth; Alcántara, Soledad (2013-03-06)
      Article
      Restricted access - publisher's policy
      To develop tissue engineering strategies useful for repairing damage in the central nervous system (CNS) it is essential to design scaffolds that emulate the NSC niche and its tight control of neural cell genesis, growth, ...
    • The proangiogenic potential of a novel calcium releasing biomaterial: Impact on cell recruitment 

      Oliveira, Hugo; Catros, Sylvain; Boiziau, Claudine; Siadous, Robin; Martí Muñoz, Joan; Bareille, Reine; Rey, Sylvie; Castaño Linares, Óscar; Planell Estany, Josep Anton; Amedee, Joelle; Engel López, Elisabeth (2016-01-01)
      Article
      Open Access
      In current bone tissue engineering strategies the achievement of sufficient angiogenesis during tissue regeneration is still a major limitation in order to attain full functionality. Several strategies have been described ...
    • The proangiogenic potential of a novel calcium releasing composite biomaterial: Orthotopic in vivo evaluation 

      Oliveira, Hugo; Catros, Sylvain; Castaño Linares, Óscar; Rey, Sylvie; Siadous, Robin; Clift, Douglas; Martí Muñoz, Joan; Batista, Marc; Bareille, Reine; Planell Estany, Josep Anton; Engel López, Elisabeth; Amedee, Joelle (2017-05-01)
      Article
      Open Access
      Insufficient angiogenesis remains a major hurdle in current bone tissue engineering strategies. An extensive body of work has focused on the use of angiogenic factors or endothelial progenitor cells. However, these approaches ...
    • Towards 4th generation biomaterials: a covalent hybrid polymer-ormoglass architecture 

      Sachot, Nadège; Mateos Timoneda, Miguel Ángel; Planell Estany, Josep Anton; Velders, A. H.; lewandowska, M.; Engel López, Elisabeth; Castaño Linares, Óscar (2015-01-01)
      Article
      Open Access
      Hybrid materials are being extensively investigated with the aim of mimicking the ECM microenvironment to develop effective solutions for bone tissue engineering. However, the common drawbacks of a hybrid material are the ...