Browsing by Author "Pérez Amodio, Soledad Graciela"
Now showing items 1-20 of 21
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A microphysiological system combining electrospun fibers and electrical stimulation for the maturation of highly anisotropic cardiac tissue
(2021-06-01)
Article
Open Accesshe creation of cardiac tissue models for preclinical testing is still a non-solved problem in drug discovery, due to the limitations related to the in vitro replication of cardiac tissue complexity. Among these limitations, ... -
Bioprinting decellularized breast tissue for the development of three-dimensional breast cancer models
(2022-06-23)
Article
Open AccessThe tumor extracellular matrix (ECM) plays a vital role in tumor progression and drug resistance. Previous studies have shown that breast tissue-derived matrices could be an important biomaterial to recreate the complexity ... -
Chitosan/PEGDA based scaffolds as bioinspired materials to control in vitro angiogenesis
(Elsevier, 2021-01-01)
Article
Open AccessIn the current work, our purpose was based on the assessment of bioactive chitosan (CS)/Poly(ethylene glycol) diacrylate (PEGDA) based scaffolds ability to stimulate in vitro angiogenesis process. The bioactivation of the ... -
Combining three-dimensionality and CaP glass-PLA composites: towards an efficient vascularization in bone tissue healing
(Elsevier, 2024-11-01)
Article
Open AccessBone regeneration often fails due to implants/grafts lacking vascular supply, causing necrotic tissue and poor integration. Microsurgical techniques are used to overcome this issue, allowing the graft to anastomose. These ... -
Conductive bacterial nanocellulose-polypyrrole patches promote cardiomyocyte differentiation
(American Chemical Society, 2023-06-21)
Article
Open AccessThe low endogenous regenerative capacity of the heart, added to the prevalence of cardiovascular diseases, triggered the advent of cardiac tissue engineering in the last decades. The myocardial niche plays a critical role ... -
Development and angiogenic potential of cell-derived microtissues using microcarrier-template
(2021-02-25)
Article
Open AccessTissue engineering and regenerative medicine approaches use biomaterials in combination with cells to regenerate lost functions of tissues and organs to prevent organ transplantation. However, most of the current strategies ... -
Development of a self-assembled peptide/methylcellulose-based bioink for 3D bioprinting
(2019-11-13)
Article
Open AccessThe introduction of 3D bioprinting to fabricate living constructs with tailored architecture has provided a new paradigm for biofabrication, with the potential to overcome several drawbacks of conventional scaffold-based ... -
Development of a three-dimensional bioengineered platform for articular cartilage regeneration
(2020-01-01)
Article
Open AccessDegenerative cartilage pathologies are nowadays a major problem for the world population. Factors such as age, genetics or obesity can predispose people to suffer from articular cartilage degeneration, which involves severe ... -
Elastin-like recombinamer hydrogels as platforms for breast cancer modeling
(2023-01-04)
Article
Open AccessThe involvement of the extracellular matrix (ECM) in tumor progression has motivated the development of biomaterials mimicking the tumor ECM to develop more predictive cancer models. Particularly, polypeptides based on ... -
Electrospun conducting and biocompatible uniaxial and core-shell fibers having Poly(lactic acid), Poly(ethylene glycol), and Polyaniline for cardiac tissue engineering
(American Chemical Society (ACS), 2019-02-19)
Article
Open Access -
Engineered microtissues for the bystander therapy against cancer
(Elsevier, 2021-02-01)
Article
Open AccessThymidine kinase expressing human adipose mesenchymal stem cells (TK-hAMSCs) in combination with ganciclovir (GCV) are an effective platform for antitumor bystander therapy in mice models. However, this strategy requires ... -
Engineering cell-derived matrices: from 3D models to advanced personalized therapies
(2020-07-02)
Article
Open AccessRegenerative medicine and disease models have evolved in recent years from two to three dimensions, providing in vitro constructs that are more similar to in vivo tissues. By mimicking native tissues, cell-derived matrices ... -
Enzymatic degradation of polylactic acid fibers supported on a hydrogel for sustained release of lactate
(American Chemical Society, 2023-01-01)
Article
Open AccessThe incorporation of exogenous lactate into cardiac tissues is a regenerative strategy that is rapidly gaining attention. In this work, two polymeric platforms were designed to achieve a sustained release of lactate, ... -
Instructive microenvironments in skin wound healing: biomaterials as signal releasing platforms
(2018-04)
Article
Open AccessSkin wound healing aims to repair and restore tissue through a multistage process that involves different cells and signaling molecules that regulate the cellular response and the dynamic remodeling of the extracellular ... -
Microfluidic 3D platform to evaluate endothelial progenitor cell recruitment by bioactive materials
(2022-10-01)
Article
Open AccessMost of the conventional in vitro models to test biomaterial-driven vascularization are too simplistic to recapitulate the complex interactions taking place in the actual cell microenvironment, which results in a poor ... -
Nanotechnology approaches in chronic wound healing
(2020-06-02)
Article
Open AccessSignificance: The incidence of chronic wounds is increasing due to our aging population and the augment of people afflicted with diabetes. With the extended knowledge on the biological mechanisms underlying these diseases, ... -
PEG hydrogel containing calcium-releasing particles and mesenchymal stromal cells promote vessel maturation
(2018-02)
Article
Restricted access - publisher's policyThe use of human mesenchymal stromal cells (hMSC) for treating diseased tissues with poor vascularization has received significant attention, but low cell survival has hampered its translation to the clinic. Bioglasses and ... -
Polymeric composite dressings containing calcium-releasing nanoparticles accelerate wound healing in diabetic mice
(2020-08-07)
Article
Open AccessObjective: Wound healing is a complex process that involves the interaction between different cell types and bioactive factors. Impaired wound healing is characterized by a loss in synchronization of these interactions, ... -
The generation of a lactate-rich environment stimulates cell cycle progression and modulates gene expression on neonatal and hiPSC-derived cardiomyocytes
(Elsevier, 2022-08)
Article
Open AccessIn situ tissue engineering strategies are a promising approach to activate the endogenous regenerative potential of the cardiac tissue helping the heart to heal itself after an injury. However, the current use of complex ... -
Tuning multilayered polymeric self-standing films for controlled release of L-lactate by electrical stimulation
(2021-02-10)
Article
Open AccessWe examine different approaches for the controlled release of L-lactate, which is a signaling molecule that participates in tissue remodeling and regeneration, such as cardiac and muscle tissue. Robust, flexible, and ...
