Now showing items 1-20 of 20

    • A microphysiological system combining electrospun fibers and electrical stimulation for the maturation of highly anisotropic cardiac tissue 

      López Canosa, Adrián; Pérez Amodio, Soledad Graciela; Yanac Huertas, Eduardo; Ordoño Fernández, Jesús; Rodríguez Trujillo, Romen; Samitier Martí, Josep; Castaño Linares, Óscar; Engel López, Elisabeth (2021-06-01)
      Article
      Open Access
      he creation of cardiac tissue models for preclinical testing is still a non-solved problem in drug discovery, due to the limitations related to the in vitro replication of cardiac tissue complexity. Among these limitations, ...
    • Bioprinting decellularized breast tissue for the development of three-dimensional breast cancer models 

      Blanco Fernández, Bárbara; Rey Viñoles, Sergi; Bagci, Gülsün; Rubi Sans, Gerard; Otero, Jorge; Navajas Navarro, Daniel; Pérez Amodio, Soledad Graciela; Engel López, Elisabeth (2022-06-23)
      Article
      Open Access
      The tumor extracellular matrix (ECM) plays a vital role in tumor progression and drug resistance. Previous studies have shown that breast tissue-derived matrices could be an important biomaterial to recreate the complexity ...
    • Chitosan/PEGDA based scaffolds as bioinspired materials to control in vitro angiogenesis 

      Soriente, Alessandra; Pérez Amodio, Soledad Graciela; Fasolino, Ines; Raucci, Maria Grazia; Demitri, Christian; Engel López, Elisabeth; Ambrosio, Luigi (Elsevier, 2021-01-01)
      Article
      Open Access
      In the current work, our purpose was based on the assessment of bioactive chitosan (CS)/Poly(ethylene glycol) diacrylate (PEGDA) based scaffolds ability to stimulate in vitro angiogenesis process. The bioactivation of the ...
    • Conductive bacterial nanocellulose-polypyrrole patches promote cardiomyocyte differentiation 

      Pérez Amodio, Soledad Graciela; Martínez Hernández, Marina; Engel López, Elisabeth; Laromaine Segué, Anna; Campoy Quiles, Marioano; Srinivasan, Sumithra Yasaswini; Cler, Marina; Zapata Arteaga, Osnat; Dörling, Bernhard (American Chemical Society, 2023-06-21)
      Article
      Open Access
      The low endogenous regenerative capacity of the heart, added to the prevalence of cardiovascular diseases, triggered the advent of cardiac tissue engineering in the last decades. The myocardial niche plays a critical role ...
    • Development and angiogenic potential of cell-derived microtissues using microcarrier-template 

      Rubi Sans, Gerard; Cano Garcia, Irene; Pérez Amodio, Soledad Graciela; Blanco, Bárbara; Mateos Timoneda, Miguel Ángel; Engel López, Elisabeth (2021-02-25)
      Article
      Open Access
      Tissue engineering and regenerative medicine approaches use biomaterials in combination with cells to regenerate lost functions of tissues and organs to prevent organ transplantation. However, most of the current strategies ...
    • Development of a self-assembled peptide/methylcellulose-based bioink for 3D bioprinting 

      Cofiño, Carla; Pérez Amodio, Soledad Graciela; Semino, Carlos; Engel López, Elisabeth; Mateos Timoneda, Miguel Ángel (2019-11-13)
      Article
      Open Access
      The introduction of 3D bioprinting to fabricate living constructs with tailored architecture has provided a new paradigm for biofabrication, with the potential to overcome several drawbacks of conventional scaffold-based ...
    • Development of a three-dimensional bioengineered platform for articular cartilage regeneration 

      Rubi Sans, Gerard; Recha Sancho, Lourdes; Pérez Amodio, Soledad Graciela; Mateos Timoneda, Miguel Ángel; Semino Margrett, Carlos Eduardo; Engel López, Elisabeth (2020-01-01)
      Article
      Open Access
      Degenerative cartilage pathologies are nowadays a major problem for the world population. Factors such as age, genetics or obesity can predispose people to suffer from articular cartilage degeneration, which involves severe ...
    • Elastin-like recombinamer hydrogels as platforms for breast cancer modeling 

      Blanco Fernández, Bárbara; Ximenes Carballo, Celia; Pérez Amodio, Soledad Graciela; Rodriguez Cabello, Jose Carlos; Engel López, Elisabeth (2023-01-04)
      Article
      Open Access
      The involvement of the extracellular matrix (ECM) in tumor progression has motivated the development of biomaterials mimicking the tumor ECM to develop more predictive cancer models. Particularly, polypeptides based on ...
    • Electrospun conducting and biocompatible uniaxial and core-shell fibers having Poly(lactic acid), Poly(ethylene glycol), and Polyaniline for cardiac tissue engineering 

      Bertuoli, Paula T.; Ordoño Fernández, Jesús; Armelín Diggroc, Elaine Aparecida; Pérez Amodio, Soledad Graciela; Baldissera, A. F.; Ferreira, Carlos A.; Puiggalí Bellalta, Jordi; Engel López, Elisabeth; Valle Mendoza, Luis Javier del; Alemán Llansó, Carlos (American Chemical Society (ACS), 2019-02-19)
      Article
      Open Access
    • Engineered microtissues for the bystander therapy against cancer 

      Blanco Fernández, Bárbara; Cano Torres, Irene; Garrido, Cristina; Rubi Sans, Gerard; Sanchez Cid, Lourdes; Guerra Rebollo, Marta; Rubio, Nuria; Blanco, Jeronimo; Pérez Amodio, Soledad Graciela; Mateos Timoneda, Miguel Ángel; Engel López, Elisabeth (Elsevier, 2021-02-01)
      Article
      Open Access
      Thymidine kinase expressing human adipose mesenchymal stem cells (TK-hAMSCs) in combination with ganciclovir (GCV) are an effective platform for antitumor bystander therapy in mice models. However, this strategy requires ...
    • Engineering cell-derived matrices: from 3D models to advanced personalized therapies 

      Rubi Sans, Gerard; Castaño Linares, Óscar; Cano Torres, Irene; Mateos Timoneda, Miguel Ángel; Pérez Amodio, Soledad Graciela; Engel López, Elisabeth (2020-07-02)
      Article
      Open Access
      Regenerative medicine and disease models have evolved in recent years from two to three dimensions, providing in vitro constructs that are more similar to in vivo tissues. By mimicking native tissues, cell-derived matrices ...
    • Enzymatic degradation of polylactic acid fibers supported on a hydrogel for sustained release of lactate 

      Colombi, Samuele; Macor, Lorena Paola; Ortiz Membrado, Laia; Pérez Amodio, Soledad Graciela; Jiménez Piqué, Emilio; Engel López, Elisabeth; Pérez Madrigal, Maria del Mar; García Torres, José Manuel; Alemán Llansó, Carlos (American Chemical Society, 2023-01-01)
      Article
      Restricted access - publisher's policy
      The incorporation of exogenous lactate into cardiac tissues is a regenerative strategy that is rapidly gaining attention. In this work, two polymeric platforms were designed to achieve a sustained release of lactate, ...
    • Instructive microenvironments in skin wound healing: biomaterials as signal releasing platforms 

      Castaño, Óscar; Pérez Amodio, Soledad Graciela; Navarro Requena, Claudia; Mateos Timoneda, Miguel Ángel; Engel López, Elisabeth (2018-04)
      Article
      Open Access
      Skin wound healing aims to repair and restore tissue through a multistage process that involves different cells and signaling molecules that regulate the cellular response and the dynamic remodeling of the extracellular ...
    • Microfluidic 3D platform to evaluate endothelial progenitor cell recruitment by bioactive materials 

      López Canosa, Adrián; Pérez Amodio, Soledad Graciela; Engel López, Elisabeth; Castaño Linares, Óscar (2022-10-01)
      Article
      Open Access
      Most of the conventional in vitro models to test biomaterial-driven vascularization are too simplistic to recapitulate the complex interactions taking place in the actual cell microenvironment, which results in a poor ...
    • Nanotechnology approaches in chronic wound healing 

      Blanco Fernández, Bárbara; Castaño, Óscar; Mateos Timoneda, Miguel Ángel; Engel López, Elisabeth; Pérez Amodio, Soledad Graciela (2020-06-02)
      Article
      Open Access
      Significance: The incidence of chronic wounds is increasing due to our aging population and the augment of people afflicted with diabetes. With the extended knowledge on the biological mechanisms underlying these diseases, ...
    • PEG hydrogel containing calcium-releasing particles and mesenchymal stromal cells promote vessel maturation 

      Navarro Requena, Claudia; Weaver, Jessica D.; Clark, Amy Y.; Clift, Douglas; Pérez Amodio, Soledad Graciela; Castaño Linares, Óscar; Zhou, Dennis W.; García, Andrés J.; Engel López, Elisabeth (2018-02)
      Article
      Restricted access - publisher's policy
      The use of human mesenchymal stromal cells (hMSC) for treating diseased tissues with poor vascularization has received significant attention, but low cell survival has hampered its translation to the clinic. Bioglasses and ...
    • Polymeric composite dressings containing calcium-releasing nanoparticles accelerate wound healing in diabetic mice 

      Pérez Amodio, Soledad Graciela; Rubio, Nuria; Vila, Olaia; Navarro Requena, Claudia; Castaño, Óscar; Sanchez Ferrero, Aitor; Martí Muñoz, Joan; Alsina Gibert, Merce; Blanco Fernández, Jerónimo; Engel López, Elisabeth (2020-08-07)
      Article
      Open Access
      Objective: Wound healing is a complex process that involves the interaction between different cell types and bioactive factors. Impaired wound healing is characterized by a loss in synchronization of these interactions, ...
    • The generation of a lactate-rich environment stimulates cell cycle progression and modulates gene expression on neonatal and hiPSC-derived cardiomyocytes 

      Ordoño Fernández, Jesús; Pérez Amodio, Soledad Graciela; Engel López, Elisabeth (Elsevier, 2022-08)
      Article
      Open Access
      In situ tissue engineering strategies are a promising approach to activate the endogenous regenerative potential of the cardiac tissue helping the heart to heal itself after an injury. However, the current use of complex ...
    • Tuning multilayered polymeric self-standing films for controlled release of L-lactate by electrical stimulation 

      Puiggalí Jou, Anna; Ordoño Fernández, Jesús; Valle Mendoza, Luis Javier del; Pérez Amodio, Soledad Graciela; Engel López, Elisabeth; Alemán Llansó, Carlos (2021-02-10)
      Article
      Open Access
      We examine different approaches for the controlled release of L-lactate, which is a signaling molecule that participates in tissue remodeling and regeneration, such as cardiac and muscle tissue. Robust, flexible, and ...
    • Wound healing-promoting effects stimulated by extracellular calcium and calcium-releasing nanoparticles on dermal fibroblasts 

      Navarro Requena, Claudia; Pérez Amodio, Soledad Graciela; Castaño, Óscar; Engel López, Elisabeth (2018-07-24)
      Article
      Open Access
      Extracellular calcium has been proved to influence the healing process of injuries and could be used as a novel therapy for skin wound healing. However, a better understanding of its effect, together with a system to obtain ...