Browsing by Author "Vallmitjana Lees, Alexander"
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Ageing is associated with deterioration of calcium homeostasis in isolated human right atrial myocytes
Herrainz, Adela; Álvarez-García, Jesus; Llach, A; Molina, Cristina E.; Fernandes, Jacqueline; Ferrero-Gregori, Andreu; Rodríguez, Cristina; Vallmitjana Lees, Alexander; Benítez Iglesias, Raúl; Padró, Josep M.; Martínez-González, José; Cinca Cosculluela, Juan; Hove-Madsen, Leif (2015-02-24)
Article
Open AccessAgeing-related cardiac disorders such as heart failure and atrial fibrillation often present with intracellular calcium homeostasis dysfunction. However, knowledge of the intrinsic effects of ageing on cellular calcium ... -
Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations
Riveras Torres, Jose; Calvo, Conrado J.; Llach, Anna; Gúzman Martínez, Gabriela; Caballero, Ricardo; González Gómez, Cristina; Jiménez Borreguero, Luís J.; Guadix, Juan A.; Osorio, Fernando G.; López Otín, Carlos; Herraiz Martínez, Adela; Cabello, Nuria; Vallmitjana Lees, Alexander; Benítez Iglesias, Raúl; Gordon, Leslie B. (2016-11-15)
Article
Open AccessHutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disease caused by defective prelamin A processing, leading to nuclear lamina alterations, severe cardiovascular pathology, and premature death. Prelamin A ... -
Detection of calcium release from individual RyR2 clusters in cardiomyocites
Nolla Colomer, Carme; Vallmitjana Lees, Alexander; Hove-Madsen, Leif; Benítez Iglesias, Raúl (2020-02)
Article
Restricted access - publisher's policyCardiac ryanodine receptors (RyR2s) are Ca2þ release channels clustering in the sarcoplasmic reticulum membrane. These clusters are believed to be the elementary units of Ca2þ release. The distribution of these Ca2þ release ... -
Distribution and function of cardiac ryanodine receptor clusters in live ventricular myocytes
Hiess, Florian; Vallmitjana Lees, Alexander; Wang, Ruiwu; Cheng, Hongqiang; ter Keurs, Henk; Chen, Ju; Hove Madsen, Leif; Benítez Iglesias, Raúl; Chen, S. R. Wayne (2015-08-14)
Article
Open AccessThe cardiac Ca2+ release channel (ryanodine receptor, RyR2) plays an essential role in excitation-contraction coupling in cardiac muscle cells. Effective and stable excitation-contraction coupling critically depends not ... -
Dynamic and irregular distribution of RyR2 clusters in the periphery of live ventricular myocytes
Hiess, Florian; Detampel, Pascal; Nolla Colomer, Carme; Vallmitjana Lees, Alexander; Ganguly, Anutosh; Amrein, Matthias; ter Keurs, Henk E.D.J; Benítez Iglesias, Raúl; Hove-Madsen, Leif; Chen, S. R. Wayne (2018-01-23)
Article
Open AccessCardiac ryanodine receptors (RyR2s) are Ca2+ release channels clustering in the sarcoplasmic reticulum membrane. These clusters are believed to be the elementary units of Ca2+ release. The distribution of these Ca2+ release ... -
Identification of intracellular calcium dynamics in stimulated cardiomyocytes
Vallmitjana Lees, Alexander; Barriga, Montserrat; Nenadic, Zoran; Llach, Anna; Álvarez Lacalle, Enrique; Hove-Madsen, Leif; Benítez Iglesias, Raúl (IEEE Press. Institute of Electrical and Electronics Engineers, 2010)
Conference report
Open AccessWe have developed an automatic method for the analysis and identification of dynamical regimes in intracellular calcium patterns from confocal calcium images. The method allows the identification of different dynamical ... -
Low density lipoproteins promote unstable calcium handling accompanied by reduced SERCA2 and connexin-40 expression in cardiomyocytes
Barriga, Montserrat; Cal, Roi; Cabello, Nuria; Llach, Anna; Vallmitjana Lees, Alexander; Benítez Iglesias, Raúl; Badimón, Lina; Cinca, J.; Llorente-Cortés, Vicenta; Hove-Madsen, Leif (2013-03-13)
Article
Open AccessThe damaging effects of high plasma levels of cholesterol in the cardiovascular system are widely known, but little attention has been paid to direct effects on cardiomyocyte function. We therefore aimed at testing the ... -
Multilevel analysis of calcium dynamics in stimulated cultures of cardiomyocytes
Vallmitjana Lees, Alexander; Hove-Madsen, Leif; Barriga, Montserrat; Benítez Iglesias, Raúl (Institute of Electrical and Electronics Engineers (IEEE), 2013)
Conference report
Restricted access - publisher's policyWe present an automatic method to characterize calcium activity in a culture of cardiac cells from a sequence of microscopy fluorescence images. The approach quantifies both the response of each individual cell in the ... -
Multiscale image analysis of calcium dynamics in cardiac myocytes
Vallmitjana Lees, Alexander (Universitat Politècnica de Catalunya, 2017-09-22)
Doctoral thesis
Open AccessCardiac myocytes constitute a unique physiological system. They are the muscle cells that build up heart tissue and provide the force to pump blood by synchronously contracting at every beat. This contraction is regulated ... -
Phospholamban knockout breaks arrhythmogenic Ca2+ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice
Bai, Yunlong; Jones, Peter; Guo, Jiqing; Zhong, Xiaowei; Clark, Robert; Zhou, Qiang; Wang, Ruiwu; Vallmitjana Lees, Alexander; Benítez Iglesias, Raúl; Hove-Madsen, Leif; Semeniuk, Lisa; Guo, Ang; Song, Long-Sheng; Duff, Henry J.; Chen, S.R. Wayne (2013-07-15)
Article
Restricted access - publisher's policyRationale: Phospholamban (PLN) is an inhibitor of cardiac sarco(endo)plasmic reticulum Ca2+ ATPase. PLN knockout (PLN-KO) enhances sarcoplasmic reticulum Ca2+ load and Ca2+ leak. Conversely, PLN-KO accelerates Ca2+ ... -
Prevention of adenosine A2A receptor activation diminishes beat-to-beat alternation in human atrial myocytes
Llacher Alsina, Anna Pilar; Vallmitjana Lees, Alexander; Benítez Iglesias, Raúl; Montiel Dacosta, José Antonio; Cinca Cusculluela, Juan (2016-01-01)
Article
Open Access© 2015, Springer-Verlag Berlin Heidelberg. Atrial fibrillation (AF) has been associated with increased spontaneous calcium release from the sarcoplasmic reticulum and linked to increased adenosine A2A receptor (A2AR) ... -
Reduced expression of cardiac ryanodine receptor protects against stress-induced ventricular tachyarrhythmia, but increases the susceptibility to cardiac alternans
Zhong, Xiaowei; Vallmitjana Lees, Alexander; Sun, Bo; Xiao, Zhichao; Benítez Iglesias, Raúl (2018-01-15)
Article
Open Access -
The 4q25 variant rs13143308T links risk of atrial fibrillation to defective calcium homoeostasis
Herraiz Martínez, Adela; Llach Martínez, Anna; Tarifa Lora, Carmen; Gandía, Jorge; Jiménez Sábado, Verónica; Lozano Velasco, Estefanía; Serra Pascual, Selma A.; Vallmitjana Lees, Alexander; Vázquez Ruiz de Castroviejo, Eduardo; Benítez Iglesias, Raúl (2019-03-01)
Article
Open AccessAims: Single nucleotide polymorphisms on chromosome 4q25 have been associated with risk of atrial fibrillation (AF) but the exiguous knowledge of the mechanistic links between these risk variants and underlying ... -
The cardiac ryanodine receptor, but not sarcoplasmic reticulum Ca2-ATPase, is a major determinant of Ca2 alternans in intact mouse hearts
Sun, Bo; Wei, Jinhong; Zhong, Xiaowei; Vallmitjana Lees, Alexander; Benítez Iglesias, Raúl (2018-07-09)
Article
Open AccessSarcoplasmic reticulum (SR) Ca2+ cycling is governed by the cardiac ryanodine receptor (RyR2) and SR Ca2+-ATPase (SERCA2a). Abnormal SR Ca2+ cycling is thought to be the primary cause of Ca2+ alternans that can elicit ...