Browsing by Author "Vallmitjana Lees, Alexander"
Now showing items 1-12 of 12
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Ageing is associated with deterioration of calcium homeostasis in isolated human right atrial myocytes
(2015-02-24)
Article
Open AccessAgeing-related cardiac disorders such as heart failure and atrial fibrillation often present with intracellular calcium homeostasis dysfunction. However, knowledge of the intrinsic effects of ageing on cellular calcium ... -
Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations
(2016-11-15)
Article
Open AccessHutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disease caused by defective prelamin A processing, leading to nuclear lamina alterations, severe cardiovascular pathology, and premature death. Prelamin A ... -
Distribution and function of cardiac ryanodine receptor clusters in live ventricular myocytes
(2015-08-14)
Article
Open AccessThe cardiac Ca2+ release channel (ryanodine receptor, RyR2) plays an essential role in excitation-contraction coupling in cardiac muscle cells. Effective and stable excitation-contraction coupling critically depends not ... -
Identification of intracellular calcium dynamics in stimulated cardiomyocytes
(IEEE Press. Institute of Electrical and Electronics Engineers, 2010)
Conference report
Open AccessWe have developed an automatic method for the analysis and identification of dynamical regimes in intracellular calcium patterns from confocal calcium images. The method allows the identification of different dynamical ... -
Low density lipoproteins promote unstable calcium handling accompanied by reduced SERCA2 and connexin-40 expression in cardiomyocytes
(2013-03-13)
Article
Open AccessThe damaging effects of high plasma levels of cholesterol in the cardiovascular system are widely known, but little attention has been paid to direct effects on cardiomyocyte function. We therefore aimed at testing the ... -
Multilevel analysis of calcium dynamics in stimulated cultures of cardiomyocytes
(Institute of Electrical and Electronics Engineers (IEEE), 2013)
Conference report
Restricted access - publisher's policyWe present an automatic method to characterize calcium activity in a culture of cardiac cells from a sequence of microscopy fluorescence images. The approach quantifies both the response of each individual cell in the ... -
Multiscale image analysis of calcium dynamics in cardiac myocytes
(Universitat Politècnica de Catalunya, 2017-09-22)
Doctoral thesis
Open AccessCardiac myocytes constitute a unique physiological system. They are the muscle cells that build up heart tissue and provide the force to pump blood by synchronously contracting at every beat. This contraction is regulated ... -
Phospholamban knockout breaks arrhythmogenic Ca2+ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice
(2013-07-15)
Article
Restricted access - publisher's policyRationale: Phospholamban (PLN) is an inhibitor of cardiac sarco(endo)plasmic reticulum Ca2+ ATPase. PLN knockout (PLN-KO) enhances sarcoplasmic reticulum Ca2+ load and Ca2+ leak. Conversely, PLN-KO accelerates Ca2+ ... -
Prevention of adenosine A2A receptor activation diminishes beat-to-beat alternation in human atrial myocytes
(2016-01-01)
Article
Open Access© 2015, Springer-Verlag Berlin Heidelberg. Atrial fibrillation (AF) has been associated with increased spontaneous calcium release from the sarcoplasmic reticulum and linked to increased adenosine A2A receptor (A2AR) ... -
The 4q25 variant rs13143308T links risk of atrial fibrillation to defective calcium homoeostasis
(2019-03-01)
Article
Open AccessAims: Single nucleotide polymorphisms on chromosome 4q25 have been associated with risk of atrial fibrillation (AF) but the exiguous knowledge of the mechanistic links between these risk variants and underlying ... -
The cardiac ryanodine receptor, but not sarcoplasmic reticulum Ca2-ATPase, is a major determinant of Ca2 alternans in intact mouse hearts
(2018-07-09)
Article
Open AccessSarcoplasmic reticulum (SR) Ca2+ cycling is governed by the cardiac ryanodine receptor (RyR2) and SR Ca2+-ATPase (SERCA2a). Abnormal SR Ca2+ cycling is thought to be the primary cause of Ca2+ alternans that can elicit ...
