Browsing by Author "Malandrino, Andrea"
Now showing items 1-14 of 14
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A micro-macro evaluation of the vertebral bony endplate permeability based on computational fluid dynamics
(2011)
Conference report
Open AccessThe intrinsic permeability is an important parameter that describes the resistance of a porous structure to fluid flo w. It has a key role in poroelastic finite element models of spinal segments, especially at ... -
Anisotropic tissue elasticity in human lumbar vertebra, by means of a coupled ultrasound-micromechanics approach
(2012-07-01)
Article
Restricted access - publisher's policyThe extremely fi ne structure of vertebral cortex challenges reliable determination of the tissue's anisotropic elasticity, which is important for the spine's load carrying patterns often causing pain in patients. As a ... -
Comparison of four methods to simulate swelling in poroelastic finite element models of intervertebral discs
(2011-10)
Article
Restricted access - publisher's policyOsmotic phenomena influence the intervertebral disc biomechanics. Their simulation is challenging and can be undertaken at different levels of complexity. Four distinct approaches to simulate the osmotic behaviour of the ... -
Derivation and characterisation of endothelial cells from patients with chronic thromboembolic pulmonary hypertension
(Nature, 2021-09-22)
Article
Open Access
Covenantee: Hospital Clínic i Provincial de Barcelona / Institut de Bioenginyeria de Catalunya / Universiteit LeidenPulmonary endarterectomy (PEA) resected material offers a unique opportunity to develop an in vitro endothelial cell model of chronic thromboembolic pulmonary hypertension (CTEPH). We aimed to comprehensively analyze the ... -
Editorial: Mechanobiology and the microenvironment: Computational and experimental approaches
(Frontiers Media SA, 2022-10-21)
Article
Open Access -
Emergent mechanical control of vascular morphogenesis
(2023-08-11)
Article
Open AccessVascularization is driven by morphogen signals and mechanical cues that coordinately regulate cellular force generation, migration, and shape change to sculpt the developing vascular network. However, it remains unclear ... -
Endothelium and subendothelial matrix mechanics modulate cancer cell transendothelial migration
(John Wiley & sons, 2023-06-02)
Article
Open AccessCancer cell extravasation, a key step in the metastatic cascade, involves cancer cell arrest on the endothelium, transendothelial migration (TEM), followed by the invasion into the subendothelial extracellular matrix (ECM) ... -
Fiber alignment in 3D collagen networks as a biophysical marker for cell contractility
(Elsevier, 2023-12-01)
Article
Restricted access - publisher's policyCells cultured in 3D fibrous biopolymer matrices exert traction forces on their environment that induce deformations and remodeling of the fiber network. By measuring these deformations, the traction forces can be reconstructed ... -
Multi-scale biomechanical study of transport phenomena in the intervertebral disc
(Universitat Politècnica de Catalunya, 2012-07-26)
Doctoral thesis
Open AccessIntervertebral disc (IVD) degeneration is primarily involved in back pain, a morbidity that strongly affects the quality of life of individuals nowadays. Lumbar IVDs undergo stressful mechanical loads while being the largest ... -
Poroelastic osmoregulation of living cell volume
(Elsevier, 2021-12)
Article
Open AccessCells maintain their volume through fine intracellular osmolarity regulation. Osmotic challenges drive fluid into or out of cells causing swelling or shrinkage, respectively. The dynamics of cell volume changes depending ... -
Regional annulus fibre orientations used as a tool for the calibration of lumbar intervertebral disc finite element models
(Gordon and Breach Science Publishers, 2011-01-06)
Article
Restricted access - publisher's policyThe collagen network of the annulus fibrosus largely controls the functional biomechanics of the lumbar intervertebral discs (IVDs). Quantitative anatomical examinations have shown bundle orientation patterns, possibly ... -
Regional annulus fibre orientations used as a tool for the calibration of lumbar intervertebral disc finite element models
(2010)
Conference report
Open AccessThe highly organized collagen network of human lumbar a nnulus fibrosus (AF) is fundamental to preserve the mechanical inte grity of the interverte bral discs. In the healthy AF, fibres are embedded in a hydrated matrix ... -
Statistical factorial analysis on the poroelastic material properties sensitivity of the lumbar intervertebral disc under compression, flexion and axial rotation
(2009-12)
Article
Restricted access - publisher's policyA statistical factorial analysis approach was conducted on a poroelastic finite element model of a lumbar intervertebral disc to analyse the influence of six material parameters (permeabilities of annulus, nucleus, trabecular ... -
The effect of sustained compression on oxygen metabolic transport in the intervertebral disc decreases with degenerative changes
(2011-08-04)
Article
Open AccessIntervertebral disc metabolic transport is essential to the functional spine and provides the cells with the nutrients necessary to tissue maintenance. Disc degenerative changes alter the tissue mechanics, but interactions ...
