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The key feature of calcium phosphate cements (CPCs) lies in the setting reaction triggered by mixing one
or more solid calcium phosphate salts with an aqueous solution. Upon mixture, the reaction takes place
through a dissolution–precipitation process which is macroscopically observed by a gradual hardening of
the cement paste. The precipitation of hydroxyapatite nanocrystals at body or room temperature, and the
fact that those materials can be used as self-setting pastes, have for many years been the most attractive
features of CPCs. However, the need to develop materials able to sustain bone tissue ingrowth and be
capable of delivering drugs and bioactive molecules, together with the continuous requirement from surgeons
to develop more easily handling cements, has pushed the development of new processing routes
that can accommodate all these requirements, taking advantage of the possibility of manipulating the
self-setting CPC paste. It is the goal of this paper to provide a brief overview of the new processing developments
in the area of CPCs and to identify the most significant achievements.
CitationGinebra, M. [et al.]. New processing approaches in calcium phosphate cements and their applications in regenerative medicine. "Acta biomaterialia", Agost 2010, vol. 6, núm. 8, p. 2863-2873.
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