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A new gene-based association test for genome-wide association studies
dc.contributor.author | Buil, Alfonso |
dc.contributor.author | Martínez-Pérez, Angel |
dc.contributor.author | Perera Lluna, Alexandre |
dc.contributor.author | Rib, Leonor |
dc.contributor.author | Caminal Magrans, Pere |
dc.contributor.author | Soria, José Manuel |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial |
dc.date.accessioned | 2010-10-15T09:31:28Z |
dc.date.available | 2010-10-15T09:31:28Z |
dc.date.created | 2009-12-15 |
dc.date.issued | 2009-12-15 |
dc.identifier.citation | Buil, A. [et al.]. A new gene-based association test for genome-wide association studies. "BMC proceedings (Online)", 15 Desembre 2009, vol. 15, núm. 3, p. 1-5. |
dc.identifier.issn | 1753-6561 |
dc.identifier.uri | http://hdl.handle.net/2117/9715 |
dc.description.abstract | Genome-wide association studies are widely used today to discover genetic factors that modify the risk of complex diseases. Usually, these methods work in a SNP-by-SNP fashion. We present a gene-based test that can be applied in the context of genome-wide association studies. We compare both strategies, SNP-based and gene-based, in a sample of cases and controls for rheumatoid arthritis. We obtained different results using each strategy. The SNP-based test found the PTPN22 gene while the gene-based test found the PHF19-TRAF1-C5 region. That suggests that no single strategy performs better than another in all cases and that a certain underlying genetic architecture can be delineated more easily with one strategy rather than with another. |
dc.format.extent | 5 p. |
dc.language.iso | eng |
dc.subject | Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica |
dc.subject.lcsh | Gene mapping -- Mathematical models |
dc.subject.lcsh | Single-nucleotide polymorphism |
dc.subject.lcsh | Rheumatoid arthritis |
dc.title | A new gene-based association test for genome-wide association studies |
dc.type | Article |
dc.subject.lemac | Artritis reumatoide |
dc.subject.lemac | Genètica mèdica |
dc.contributor.group | Universitat Politècnica de Catalunya. SISBIO - Senyals i Sistemes Biomèdics |
dc.identifier.doi | 10.1186/1753-6561-3-S7-S130 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795904/?tool=pubmed |
dc.rights.access | Open Access |
local.identifier.drac | 3257239 |
dc.description.version | Postprint (published version) |
local.citation.author | Buil, A.; Martínez-Pérez, A.; Perera, A.; Rib, L.; Caminal, P.; Soria, J. |
local.citation.publicationName | BMC proceedings (Online) |
local.citation.volume | 15 |
local.citation.number | 3 |
local.citation.startingPage | 1 |
local.citation.endingPage | 5 |
dc.identifier.pmid | 20017997 |
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