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Search of phenotype-related candidate genes using Gene Ontology-based semantic similarity and protein interaction information: application to Brugada syndrome
dc.contributor.author | Massanet Vila, Raimon |
dc.contributor.author | Gallardo Chacón, Joan Josep |
dc.contributor.author | Caminal Magrans, Pere |
dc.contributor.author | Perera Lluna, Alexandre |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial |
dc.date.accessioned | 2010-10-15T08:44:49Z |
dc.date.available | 2010-10-15T08:44:49Z |
dc.date.created | 2009 |
dc.date.issued | 2009 |
dc.identifier.citation | Massanet, R. [et al.]. Search of phenotype-related candidate genes using Gene Ontology-based semantic similarity and protein interaction information: application to Brugada syndrome. A: IEEE Engineering in Medicine and Biology Society. Annual International Conference. "31st Annual International IEEE EMBS Conference". Minneapolis: IEEE Press. Institute of Electrical and Electronics Engineers, 2009, p. 7079-7082. |
dc.identifier.uri | http://hdl.handle.net/2117/9709 |
dc.description.abstract | This work presents a methodology for finding phenotype candidate genes starting from a set of known related genes. This is accomplished by automatically mining and organizing the available scientific literature using Gene Ontology-based semantic similarity. As a case study, Brugada syndrome related genes have been used as input in order to obtain a list of other possible candidate genes related with this disease. Brugada anomaly produces a typical alteration in the Electrocardiogram and carriers of the disease show an increased probability of sudden death. Results show a set of semantically coherent proteins that are shown to be related with synaptic transmission and muscle contraction physiological processes. |
dc.format.extent | 4 p. |
dc.language.iso | eng |
dc.publisher | IEEE Press. Institute of Electrical and Electronics Engineers |
dc.subject | Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica |
dc.subject.lcsh | Brugada syndrome |
dc.subject.lcsh | Ontologies (artificial intelligence) |
dc.subject.lcsh | Electrocardiography |
dc.subject.lcsh | Heart--Diseases -- Genetic aspects |
dc.title | Search of phenotype-related candidate genes using Gene Ontology-based semantic similarity and protein interaction information: application to Brugada syndrome |
dc.type | Conference report |
dc.subject.lemac | Síndrome de Brugada |
dc.subject.lemac | Malalties coronàries |
dc.contributor.group | Universitat Politècnica de Catalunya. SISBIO - Senyals i Sistemes Biomèdics |
dc.identifier.doi | 10.1109/IEMBS.2009.5332918 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | http://ieeexplore.ieee.org/search/srchabstract.jsp?tp=&arnumber=5332918&queryText%3Dperera+and+caminal%26openedRefinements%3D*%26sortType%3Ddesc_Publication+Year%26searchField%3DSearch+All |
dc.rights.access | Open Access |
local.identifier.drac | 3257637 |
dc.description.version | Postprint (published version) |
local.citation.author | Massanet, R.; Gallardo, J.; Caminal, P.; Perera, A. |
local.citation.contributor | IEEE Engineering in Medicine and Biology Society. Annual International Conference |
local.citation.pubplace | Minneapolis |
local.citation.publicationName | 31st Annual International IEEE EMBS Conference |
local.citation.startingPage | 7079 |
local.citation.endingPage | 7082 |