Daytime Ayahuasca administration modulates REM and slow-wave sleep in healthy volunteers
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Ayahuasca is a traditional South American psychoactive beverage and the central sacrament of Brazilianbased religious groups, with followers in Europe and the United States. The tea contains the psychedelic indole N, N-dimethyltryptamine (DMT) and β-carboline alkaloids with monoamine oxidase-inhibiting properties that render DMT orally active. DMT interacts with serotonergic neurotransmission acting as a partial agonist at 5-HT1A and 5-HT2A/2C receptor sites. Given the role played by serotonin in the regulation of the sleep/wake cycle, we investigated the effects of daytime ayahuasca consumption in sleep parameters.
CitationBarbanoj, M. [et al.]. Daytime Ayahuasca administration modulates REM and slow-wave sleep in healthy volunteers. "Psychopharmacology", Febrer 2008, vol. 196, núm. 2, p. 315-326.