Macroscopic deformations in embryonic soft tissues are due to the intra-cellular remodelling
and cell intercalation. We here present a computational approach that can handle the
two types of deformations, and also take into account the active cell response. The model resorts
to cell-centred techniques, where particles represent cell nuclei, and to vertex models, where the
vertices represent cell boundaries. This hybrid approach allows to consider separately intracellular
and inter-cellular forces, and at the same time impose cell incompressibility.
In the proposed model, the cell boundaries (defined by vertices) and cell nuclei (or cellcentres)
networks are coupled through an interpolation scheme, which is eventually relaxed in
order to smooth the cell boundaries. We show that this coupling between the two networks
modifies the equilibrium equations and stabilises the vertex network. Incompressibility is implemented
through a penalty method. The resulting model can be implemented in two- and
three-dimensions, and is complemented with active rheological models.
We apply the model to simulate the stretching and relaxation of cell monolayers, and to
simulate wound healing process in the wing disc of Drosophila fly embryo. We show that the
numerical results agree with the experimental measurements.
CitacióMuñoz, J.J., Mosafa, P., Mao, Y., Tetley, R., Asadipour, N., Rodriguez-Ferran, A. Hybrid cell centred/vertex model for large tissue deformations. A: ECCOMAS Congress 2016. "European Congress on Computational Methods in Applied Sciences and Engineering, ECCOMAS 2016". Creta: 2016, p. 1-9.