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Escherichia coli and pseudomonas aeruginosa eradication by nano-penicillin G
dc.contributor.author | Macedo Fernandes, Margarida Maria |
dc.contributor.author | Ivanova, Kristina Dimitrova |
dc.contributor.author | Francesko, Antonio |
dc.contributor.author | Rivera, Diana |
dc.contributor.author | Torrent Burgués, Juan |
dc.contributor.author | Mendoza Gómez, Ernesto |
dc.contributor.author | Tzanov, Tzanko |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria Química |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Física |
dc.date.accessioned | 2016-09-21T11:43:01Z |
dc.date.available | 2017-10-03T00:30:10Z |
dc.date.issued | 2016-06-09 |
dc.identifier.citation | Macedo, M.M., Ivanova, K., Francesko, A., Rivera, D., Torrent, J.; Torrent-Burgués, J., Mendoza, E., Tzanov, T. Escherichia coli and pseudomonas aeruginosa eradication by nano-penicillin G. "Nanomedicine: nanotechnology, biology and medicine", 9 Juny 2016, vol. 12, núm. 7, p. 2061-2069. |
dc.identifier.issn | 1549-9634 |
dc.identifier.uri | http://hdl.handle.net/2117/90102 |
dc.description.abstract | The transformation of penicillin G into nano/micro-sized spheres (nanopenicillin) using sonochemical technology was explored as a novel tool for the eradication of Gram-negative bacteria and their biofilms. Known by its effectiveness only against Gram-positive microorganisms, the penicillin G spherization boosted the inhibition of the Gram-negative Pseudomonas aeruginosa 10-fold (from 0.3 to 3.0 log-reduction) and additionally induced 1.2 log-reduction of Escherichia coli growth. The efficient penetration of the spheres within a Langmuir monolayer sustained the theory that nanopenicillin is able to cross the membrane and reach the periplasmic space in Gram-negative bacteria where they inhibit the ß-lactam targets: the transferases that build the bacteria cell wall. Moreover, it considerably suppressed the growth of both bacterial biofilms on a medically relevant polystyrene surface, leaving majority of the adhered cells dead compared to the treatment with the non-processed penicillin G. Importantly, nanopenicillin was found innocuous towards human fibroblasts at the antibacterial-effective concentration |
dc.format.extent | 9 p. |
dc.language.iso | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria química |
dc.subject.lcsh | Bioengineering |
dc.subject.lcsh | Nanoparticles--Therapeutic use |
dc.subject.other | Penicillin G |
dc.subject.other | Sonochemistry |
dc.subject.other | Nano/Microspheres |
dc.subject.other | Nano-bio interactions |
dc.subject.other | Antibacterial |
dc.subject.other | Antibiofilm |
dc.title | Escherichia coli and pseudomonas aeruginosa eradication by nano-penicillin G |
dc.type | Article |
dc.subject.lemac | Bioenginyeria |
dc.subject.lemac | Nanopartícules -- Ús terapèutic |
dc.contributor.group | Universitat Politècnica de Catalunya. GBMI - Grup de Biotecnologia Molecular i Industrial |
dc.identifier.doi | 10.1016/j.nano.2016.05.018 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | http://www.nanomedjournal.com/article/S1549-9634(16)30065-X/abstract |
dc.rights.access | Open Access |
local.identifier.drac | 18768186 |
dc.description.version | Postprint (published version) |
local.citation.author | Macedo, M.M., Ivanova, K., Francesko, A., Rivera, D., Torrent, J.; Torrent-Burgués, J., Mendoza, E., Tzanov, T. |
local.citation.publicationName | Nanomedicine: nanotechnology, biology and medicine |
local.citation.volume | 12 |
local.citation.number | 7 |
local.citation.startingPage | 2061 |
local.citation.endingPage | 2069 |
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