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dc.contributor.authorDies, Marta
dc.contributor.authorGalera Laporta, Leticia
dc.contributor.authorGarcía Ojalvo, Jordi
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Física
dc.date.accessioned2016-06-22T14:16:57Z
dc.date.available2017-01-03T01:30:32Z
dc.date.issued2016-01-01
dc.identifier.citationDies, M., Galera, L., Garcia, J. Mutual regulation causes co-entrainment between a synthetic oscillator and the bacterial cell cycle. "Integrative Biology", 01 Gener 2016, vol. 8, núm. 4, p. 533-541.
dc.identifier.issn1757-9694
dc.identifier.urihttp://hdl.handle.net/2117/88243
dc.description.abstractThe correct functioning of cells requires the orchestration of multiple cellular processes, many of which are inherently dynamical. The conditions under which these dynamical processes entrain each other remain unclear. Here we use synthetic biology to address this question in the case of concurrent cellular oscillations. Specifically, we study at the single-cell level the interaction between the cell division cycle and a robust synthetic gene oscillator in Escherichia coli. Our results suggest that cell division is able to partially entrain the synthetic oscillations under normal growth conditions, by driving the periodic replication of the genes involved in the oscillator. Coupling the synthetic oscillations back into the cell cycle via the expression of a key regulator of chromosome replication increases the synchronization between the two periodic processes. A simple computational model allows us to confirm this effect.
dc.format.extent9 p.
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria agroalimentària::Ciències de la terra i de la vida::Microbiologia
dc.subject.lcshCell division
dc.subject.lcshEscherichia coli
dc.subject.lcshOscillations
dc.subject.othercircadian clock
dc.subject.otherdegradation machine
dc.subject.otheresherichia-coli
dc.subject.othergene-expression
dc.subject.otherDNA-replication
dc.subject.otherCLPXP
dc.subject.otherinitiation
dc.subject.othermechanism
dc.subject.otherdivision
dc.subject.otherdynamics
dc.titleMutual regulation causes co-entrainment between a synthetic oscillator and the bacterial cell cycle
dc.typeArticle
dc.subject.lemacEscheríchia coli
dc.subject.lemacCèl·lules -- Divisió
dc.subject.lemacOscil·lacions
dc.contributor.groupUniversitat Politècnica de Catalunya. DONLL - Dinàmica no lineal, òptica no lineal i làsers
dc.identifier.doi10.1039/c5ib00262a
dc.description.peerreviewedPeer Reviewed
dc.rights.accessOpen Access
drac.iddocument18551895
dc.description.versionPostprint (published version)
upcommons.citation.authorDies, M., Galera, L., Garcia, J.
upcommons.citation.publishedtrue
upcommons.citation.publicationNameIntegrative Biology
upcommons.citation.volume8
upcommons.citation.number4
upcommons.citation.startingPage533
upcommons.citation.endingPage541
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