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Formation of calcium phosphate nanostructures under the influence of self-assembling hybrid elastin-like-statherin recombinamers
dc.contributor.author | Hamed Misbah, M. |
dc.contributor.author | Español Pons, Montserrat |
dc.contributor.author | Quintanilla, Luis |
dc.contributor.author | Ginebra Molins, Maria Pau |
dc.contributor.author | Rodriguez Cabello, Jose Carlos |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica |
dc.date.accessioned | 2016-05-09T11:53:54Z |
dc.date.available | 2016-05-09T11:53:54Z |
dc.date.issued | 2016-01-01 |
dc.identifier.citation | Hamed, M., Español, M., Quintanilla, L., Ginebra, M.P., Rodriguez-Cabello , J.C. Formation of calcium phosphate nanostructures under the influence of self-assembling hybrid elastin-like-statherin recombinamers. "RSC advances", 01 Gener 2016, vol. 6, núm. 37, p. 31225-31234. |
dc.identifier.issn | 2046-2069 |
dc.identifier.uri | http://hdl.handle.net/2117/86772 |
dc.description.abstract | The self-assembling properties of thermally-sensitive amphiphilic elastin-like multiblock recombinamers have been combined with the capacities of calcium phosphate binding of the SN(A)15 epitope inspired by the salivary protein statherin. In this regard, the interaction between calcium and phosphate ions was examined in the presence of two hybrid recombinamers. The first recombinamer comprised a simple amphiphilic diblock in which the SN(A)15 epitopes were combined, at the gene level, to the hydrophilic end. This recombinamer can self-assemble into nanoparticles that can control the transformation of amorphous calcium phosphate (ACP) into a fibre-like hydroxyapatite structure. In the other recombinamer, the SN(A)15 domains are distributed along the monomer chain, with the hydrophilic blocks being distributed amongst the hydrophobic ones. In this case, the resulting nanohybrid ACP/recombinamer organises into neuron-like structures. Thus, combining the amphiphilic elastin-like recombinamers to the SN(A)15 functionality is a powerful mean to tune the formation of different complex calcium phosphate nanostructures. |
dc.format.extent | 10 p. |
dc.language.iso | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria dels materials |
dc.subject.lcsh | Tissue engineering |
dc.subject.lcsh | Calcium Phosphates |
dc.title | Formation of calcium phosphate nanostructures under the influence of self-assembling hybrid elastin-like-statherin recombinamers |
dc.type | Article |
dc.subject.lemac | Enginyeria de teixits |
dc.subject.lemac | Fosfat de calci |
dc.contributor.group | Universitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits |
dc.identifier.doi | 10.1039/c6ra01100d |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | http://pubs.rsc.org/en/Content/ArticleLanding/2016/RA/C6RA01100D#!divAbstract |
dc.rights.access | Open Access |
local.identifier.drac | 17754871 |
dc.description.version | Postprint (author's final draft) |
dc.relation.projectid | info:eu-repo/grantAgreement/EC/FP7/278557/EU/Tissue in Host Engineering Guided Regeneration of Arterial Intimal Layer/THE GRAIL |
dc.relation.projectid | info:eu-repo/grantAgreement/EC/FP7/263363/EU/Novel biomimetic strategy for bone regeneration/INNOVABONE |
dc.contributor.covenantee | Universidad de Valladolid |
local.citation.author | Hamed, M.; Español, M.; Quintanilla, L.; Ginebra, M.P.; Rodriguez-Cabello, J.C. |
local.citation.publicationName | RSC advances |
local.citation.volume | 6 |
local.citation.number | 37 |
local.citation.startingPage | 31225 |
local.citation.endingPage | 31234 |
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