The role of connectivity and noise in the emergence of spontaneous activity in cultured neuronal networks
Tipo de documentoArtículo
Fecha de publicación2012-10
Condiciones de accesoAcceso abierto
Cultured neurons in vitro quickly connect to one another to establish a spontaneously active network within a week. The resulting neuronal network is char- acterized by a combination of excitatory and inhibitory integrate–and–fire units coupled through synaptic connec- tions, and that interact in a highly nonlinear manner. The nonlinear behavior emerges from the dynamics of both the neurons’ membrane potential and synaptic transmission, together with intrinsic biological noise. These ingredients give rise to a rich repertoire of phenomena that are still poorly understood, including periodic spontaneous activ- ity, avalanches, propagation of activity fronts, and synchro- nization. Here we describe some experimental results on spontaneous activity in cultures, and elaborate on theoreti- cal models that describe its initiation and maintenance
CitaciónOrlandi, J., Alvarez-Lacalle, E., Teller, S., Casademunt, J., Soriano, J. The role of connectivity and noise in the emergence of spontaneous activity in cultured neuronal networks. "Proceedings of 2012 International Symposium on Nonlinear Theory and its Applications", Octubre 2012, vol. 1, p. 547-550.