Osteoblastic cell response to spark plasma-sintered zirconia/titanium cermets
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Ceramic/metal composites, cermets, arise from the idea to combine the dissimilar properties in the pure materials. This work aims to study the biocompatibility of new micro-nanostructured 3Y-TZP/Ti materials with 25, 50 and 75vol.% Ti, which have been successfully obtained by spark slasma sintering technology, as well as to correlate their surface properties (roughness, wettability and chemical composition) with the osteoblastic cell response. All samples had isotropic and slightly waved microstructure, with sub-micrometric average roughness. Composites with 75vol.% Ti had the highest surface hydrophilicity. Surface chemical composition of the cermets correlated well with the relative amounts used for their fabrication. A cell viability rate over 80% dismissed any cytotoxicity risk due to manufacturing. Cell adhesion and early differentiation were significantly enhanced on materials containing the nanostructured 3Y-TZP phase. Proliferation and differentiation of SaOS-2 were significantly improved in their late-stage on the composite with 75vol.% Ti that, from the osseointegration standpoint, is presented as an excellent biomaterial for bone replacement. Thus, spark plasma sintering is consolidated as a suitable technology for manufacturing nanostructured biomaterials with enhanced bioactivity.
CitationFernandez, E., Guillem-Marti, J., Gutierrez, C., Fernandez, A., Ginebra, M.P., Lopez, S. Osteoblastic cell response to spark plasma-sintered zirconia/titanium cermets. "Journal of biomaterials applications", 01 Gener 2015, vol. 29, núm. 6, p. 813-823.